Results 191 to 200 of about 786,405 (284)

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Aucubin Promotes Differentiation of Neural Precursor Cells into GABAergic Neurons [PDF]

, 2018
Miyeoun Song, Hyo‐Min Kim, Sujin Park, Hyockman Kwon, Insil Joung, Yunhee Kim Kwon   +5 more
openalex   +1 more source

Lateral Hypothalamus GABAergic Neurons Modulate Consummatory Behaviors Regardless of the Caloric Content or Biological Relevance of the Consumed Stimuli

Neuropsychopharmacology, 2016
M. Navarro, Jeffrey J. Olney, Nathan W. Burnham, Christopher M. Mazzone, Emily G. Lowery-Gionta, K. Pleil, T. Kash, T. E. Thiele   +7 more
semanticscholar   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Tonic GABAergic Inhibition of Sympathetic Preganglionic Neurons: A Novel Substrate for Sympathetic Control [PDF]

, 2008
Lihua Wang, Emma J. Spary, Jim Deuchars, Susan A. Deuchars   +3 more
openalex   +1 more source

Dorsal raphe nucleus MC4R-GABAergic neurons regulate feeding and anxiety. [PDF]

Mol Metab
Yamagata S, Copperi F, White GT, Kim JD, Diano S.   +4 more
europepmc   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Restoration of CB1 receptor function in hippocampal GABAergic neurons rescues memory deficits in Huntington's disease models. [PDF]

Transl Neurodegener
Di Franco N, Bengoetxea de Tena I, Sanchez-Ruiz A, Pereda-Velarde A, Enfedaque F, Gónzalez-Arias C, Rio LMM, Bortolozzi A, Rodriguez-Puertas R, Costas-Insua C, Molina-Porcel L, Vazquez-Oliver A, Ozaita A, Guzmán M, Perea G, Ginés S.   +15 more
europepmc   +1 more source

Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex

Neuron, 2016
Miao He, Miao He, J. Tucciarone, J. Tucciarone, Soohyun Lee, M. J. Nigro, Yongsoo Kim, Jesse M Levine, Jesse M Levine, S. M. Kelly, S. M. Kelly, Illya Krugikov, Priscilla Wu, Yang Chen, Ling Gong, Yongjie Hou, P. Osten, B. Rudy, Z. J. Huang   +18 more
semanticscholar   +1 more source