Respiratory dysfunction and fatal apnea during pilocarpine‐induced status epilepticus
Abstract Objective Status epilepticus (SE) is second only to sudden unexpected death in epilepsy as a cause of seizure‐related mortality. The progression of respiratory dysfunction during experimental SE remains poorly characterized. We investigated how pilocarpine‐induced SE affects respiration in mice.
Chengsan Sun +6 more
wiley +1 more source
GABAergic neurons in the ventral tegmental area represent and regulate force vectors. [PDF]
Jiang Q +5 more
europepmc +1 more source
Abstract Objective For over four decades, the substantia nigra pars reticulata (SNr) has been recognized as a critical structure in the modulation of seizure activity. Pharmacological and optogenetic inhibition of the SNr produces robust seizure suppression in a range of seizure models.
Devin Palmer, Patrick A. Forcelli
wiley +1 more source
Ephrin-B2 deletion in GABAergic neurons induces cognitive deficits associated with single-nucleus transcriptomic differences in the prefrontal cortex. [PDF]
Ju P +9 more
europepmc +1 more source
Spreading depolarization and its influence on epileptiform activity
Abstract Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K+]o, was shown ...
Maxime Lévesque +2 more
wiley +1 more source
Mesoscopic analysis of GABAergic marker distribution in cholinergic neurons in the mouse brain
Goral, Rene Oliver +3 more
openalex +1 more source
Ventral Pallidal GABAergic Neurons Drive Consumption in Male, But Not Female, Rats. [PDF]
Scott A +7 more
europepmc +1 more source
Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease
Abstract Background and Objective Lafora disease (LD) is a rare progressive disorder caused by mutations in the EPM2A or EPM2B genes, characterized by the accumulation of Lafora bodies, drug‐resistant epilepsy, and cognitive decline. To investigate the early molecular mechanisms of LD, we studied electrophysiological changes in the dentate gyrus (DG ...
Cinzia Costa +17 more
wiley +1 more source
Rebound Bursts in GABAergic Neurons of the Thalamic ReticularNucleus in Postnatal Mice
X Wang +5 more
openalex +1 more source

