Results 81 to 90 of about 786,405 (284)

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

The Hypothalamic Medial Preoptic Area–Paraventricular Nucleus Circuit Modulates Depressive-Like Behaviors in a Mouse Model of Postpartum Depression

Research
Estrogen fluctuations have been implicated in various mood disorders, including perimenopausal and postpartum depression (PPD), likely through complex neural networks.
Ping Fu, Cui-Ping Liu, Cheng-Yi Liu, Yan-Chu-Fei Zhang, Ju-Ping Xu, Rui-Ting Mao, Xue-Ying Ding, Fan Li, Yi-Long Zhang, Hai-Long Yang, Jing-Ning Zhu, Guo Zhang, Jian Jing   +12 more
doaj   +1 more source

Subtypes of GABAergic neurons project axons in the neocortex

Frontiers in Neuroanatomy, 2009
γ-aminobutyric acid (GABA)ergic neurons in the neocortex have been regarded as interneurons and speculated to modulate the activity of neurons locally.
Shigeyoshi Higo, Kaori Akashi, Kenji Sakimura, Nobuaki Tamamaki   +3 more
doaj   +1 more source

Lateral hypothalamic GABAergic neurons encode alcohol memories [PDF]

, 2023
Isis Alonso-Lozares, Pelle Wilbers, Lina Asperl, Sem Teijsse, Charlotte van der Neut, Dustin Schetters, Yvar van Mourik, Allison J. McDonald, Tim S. Heistek, Huibert D. Mansvelder, Taco J. De Vries, Nathan J. Marchant   +11 more
openalex   +1 more source

Control of REM Sleep by Ventral Medulla GABAergic Neurons

Nature, 2015
Rapid eye movement (REM) sleep is a distinct brain state characterized by activated electroencephalogram and complete skeletal muscle paralysis, and is associated with vivid dreams.
F. Weber, Shinjae Chung, Kevin T. Beier, L. Luo, Y. Dan   +4 more
semanticscholar   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Hyperactive MEK1 Signaling in Cortical GABAergic Neurons Promotes Embryonic Parvalbumin Neuron Loss and Defects in Behavioral Inhibition [PDF]

, 2020
Michael Holter, Lauren T. Hewitt, Kenji Nishimura, Sara Knowles, George R. Bjorklund, Shiv Shah, Noah Fry, Katherina P. Rees, Tanya Gupta, Carter W. Daniels, Guohui Li, Steven T. Marsh, David M. Treiman, M. Foster Olive, Trent Anderson, Federico Sanabria, William D. Snider, Jason M. Newbern   +17 more
openalex   +1 more source

An unconventional GABAergic circuit differently controls pyramidal neuron activity in two visual cortical areas via endocannabinoids [PDF]

, 2021
Martin Montmerle, Fani Koukouli, Andrea Aguirre, Jérémy Peixoto, Vikash Choudhary, Marcel de Brito van Velze, Marjorie Varilh, Francisca Julio‐Kalajzić, Camille Allène, Pablo Méndez, Giovanni Marsicano, Oliver M. Schlüter, Nelson Rebola, Alberto Bacci, Joana Lourenço   +14 more
openalex   +1 more source

Behavior‐ and Cell Type‐Specific Cortico‐Striatal Decoupling in a Parkinson's Disease‐Like Mouse Model

Advanced Science, EarlyView.
Utilizing dual‐site fiber photometry, this study examines cortico‐striatal coupling with cell type resolution, identifying behavior‐ and cell type‐specific cortico striatal decoupling and its dopamine‐dependent mechanism in a Parkinson's disease mouse model.
Xu‐Ran Yao, Yang Liu, Wei‐Tong Zheng, Mao‐Qing Huang, Kai‐Wen He   +4 more
wiley   +1 more source

Delivery of different genes into pre- and post-synaptic neocortical interneurons connected by GABAergic synapses.

PLoS ONE, 2019
Local neocortical circuits play critical roles in information processing, including synaptic plasticity, circuit physiology, and learning, and GABAergic inhibitory interneurons have key roles in these circuits.
Aarti Nagayach, Anshuman Singh, Angel L De Blas, Alfred I Geller   +3 more
doaj   +1 more source