Results 81 to 90 of about 546,048 (293)

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Birthdate study of GABAergic neurons in the lumbar spinal cord of the glutamic acid decarboxylase 67-green fluorescent protein knock-in mouse

Frontiers in Neuroanatomy, 2013
Despite the abundance of studies on γ-aminobutyric acid (GABA) ergic neuron distribution in the mouse developing spinal cord, no investigation has been devoted so far to their birthdates.
Jing eHuang, Jing eChen, Wen eWang, Guo-Hong eCai, Yan-Yan eWei, Shengxi eWu   +5 more
doaj   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Regional and sub-regional differences in hippocampal GABAergic neuronal vulnerability in the TgCRND8 mouse model of Alzheimer’s disease

Frontiers in Aging Neuroscience, 2015
Hippocampal network activity is predominantly coordinated by -amino-butyric acid (GABA)ergic neurons. We have previously hypothesized that the altered excitability of hippocampal neurons in Alzheimer's disease (AD), which manifests as increased in vivo ...
Marilia Silva Albequerque, Marilia Silva Albequerque, Marilia Silva Albequerque, Marilia Silva Albequerque, Ian eMahar, Ian eMahar, Ian eMahar, Maria Antonietta eDavoli, Maria Antonietta eDavoli, Jean-Guy eChabot, Jean-Guy eChabot, Naguib eMechawar, Naguib eMechawar, Naguib eMechawar, Naguib eMechawar, Rémi eQuirion, Rémi eQuirion, Slavica eKrantic, Slavica eKrantic, Slavica eKrantic, Slavica eKrantic   +20 more
doaj   +1 more source

PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling

Advanced Science, EarlyView.
PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu, Zitian Zheng, Feiran Wang, Huanhuan Luo, Fei Ju, Yucheng Zhu, Zheng Zhou, Jie Sun, Zhenghui Qiu, Xiang Luo, Zhongzheng Jia, Jianquan Wang, Hongjie Huang, Bo Zhang   +13 more
wiley   +1 more source

GABAergic synapses: their plasticity and role in sensory cortex

Frontiers in Cellular Neuroscience, 2014
The mammalian neocortex is composed of a variety of cell types organized in a highly interconnected circuit. GABAergic neurons account for only about 20% of cortical neurons.
Trevor C Griffen, Trevor C Griffen, Trevor C Griffen, Arianna eMaffei, Arianna eMaffei   +4 more
doaj   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

Coordinated Plasticity between Barrel Cortical Glutamatergic and GABAergic Neurons during Associative Memory

Neural Plasticity, 2016
Neural plasticity is associated with memory formation. The coordinated refinement and interaction between cortical glutamatergic and GABAergic neurons remain elusive in associative memory, which we examine in a mouse model of associative learning. In the
Fenxia Yan, Zilong Gao, Pin Chen, Li Huang, Dangui Wang, Na Chen, Ruixiang Wu, Jing Feng, Shan Cui, Wei Lu, Jin-Hui Wang   +10 more
doaj   +1 more source

Projection neurons in lamina III of the rat spinal cord are selectively innervated by local dynorphin-containing excitatory neurons [PDF]

, 2012
Large projection neurons in lamina III of the rat spinal cord that express the neurokinin 1 receptor are densely innervated by peptidergic primary afferent nociceptors and more sparsely by low-threshold myelinated afferents. However, we know little about
Todd, A.J., Polgar, Erika, Furuta, T., Watanabe, M., Baseer, N., Todd, A., Kaneko, T.   +6 more
core   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source