Results 161 to 170 of about 7,891 (186)
Association of human transferrin receptor with GABARAP [PDF]
FEBS Letters, 2002 A yeast two‐hybrid screen identified a specific interaction between the cytoplasmic domain of transferrin receptor (TfR) and GABARAP, a 14 kDa protein that binds to the γ2 subunit of neuronal GABAA receptors. The specificity of the TfR–GABARAP interaction was demonstrated by in vitro binding assays with purified proteins and by co‐immunoprecipitation ...
Caroline Enns, Aaron Blackwell
exaly +7 more sources
Prediction of GABARAP interaction with the GABA type A receptor [PDF]
Proteins: Structure, Function and Bioinformatics, 2018 AbstractWe have performed docking simulations on GABARAP interacting with the GABA type A receptor using SwarmDock. We have also used a novel method to study hydration sites on the surface of these two proteins; this method identifies regions around proteins where desolvation is relatively easy, and these are possible locations where proteins can bind ...
Benedict W J Irwin +2 more
exaly +8 more sources
Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy [PDF]
Current Biology, 2017 Autophagy maintains cellular health and homeostasis during stress by delivering cytosolic material captured by autophagosomes to lysosomes for degradation. Autophagosome formation is complex: initiated by the recruitment of autophagy (Atg) proteins to the formation site, it is sustained by activation of Atg proteins to allow growth and closure of the ...
Brian Dynlacht +2 more
exaly +3 more sources
Structural and functional analysis of the GABARAP interaction motif (GIM) [PDF]
EMBO Reports, 2017 Through the canonical LC3 interaction motif (LIR), [W/F/Y]-X1-X2-[I/L/V], protein complexes are recruited to autophagosomes to perform their functions as either autophagy adaptors or receptors.
Volker Dotsch +2 more
exaly +2 more sources
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GABARAP: Lessons for Synaptogenesis
The Neuroscientist, 2003The clustering of neurotransmitter receptors at the postsynaptic terminals is a critical requirement for efficient neurotransmission and neuronal communication. This process is facilitated by adaptor proteins, which bridge the postsynaptic receptors and the underlying cytoskeleton. One such molecule, the GABA A
Joseph E, Coyle, Dimitar B, Nikolov
openaire +2 more sources
A conserved ATG2‐GABARAP family interaction is critical for phagophore formation
EMBO Reports, 2020 Abstract The intracellular trafficking pathway, macroautophagy, is a recycling and disposal service that can be upregulated during periods of stress to maintain cellular homeostasis. An essential phase is the elongation and closure of the phagophore to seal and isolate unwanted cargo prior to lysosomal degradation.
Alan Prescott +2 more
exaly +4 more sources
LC3/GABARAP binding to fluid membranes is potentiated by ceramide
Autophagy, 2022LC3/GABARAP constitute a macroautophagy/autophagy-related protein family derived from yeast Atg8. The involvement of specific lipids in LC3/GABARAP function is poorly understood. Exploring the interaction of LC3/GABARAP proteins with phosphatidylcholine- or sphingomyelin-based bilayers has revealed that cardiolipin is essential for the protein-bilayer ...
Yaiza R Varela, Alicia Alonso
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Brain Research, 2006
GABARAP and GEC1/GABARAPL1 interact with tubulin and GABA(A) receptor and belong to a new protein family. This family includes GATE 16 and LC3, potentially involved in intracellular transport processes. In this study, we combined brain dissection and quantitative real-time reverse transcription polymerase chain reaction to study discriminatively ...
Mansuy-Schlick, Virginie +5 more
openaire +3 more sources
GABARAP and GEC1/GABARAPL1 interact with tubulin and GABA(A) receptor and belong to a new protein family. This family includes GATE 16 and LC3, potentially involved in intracellular transport processes. In this study, we combined brain dissection and quantitative real-time reverse transcription polymerase chain reaction to study discriminatively ...
Mansuy-Schlick, Virginie +5 more
openaire +3 more sources
GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3
Biochemical and Biophysical Research Communications, 2003GATE-16, GABARAP, and LC3 are three mammalian counterparts of yeast Apg8p/Aut7p. Here, we show that GATE-16 and GABARAP are authentic modifiers, as is the case of LC3 modification. The C-terminal Phe(117) of proGATE-16 and the C-terminal Leu(117) of proGABARAP are post-translationally cleaved to expose an essential Gly(116) within GATE-16 and GABARAP ...
Masaaki Komatsu +2 more
exaly +3 more sources
GABARAP is not essential for GABAA receptor targeting to the synapse
European Journal of Neuroscience, 2005AbstractGABAA receptors (GABAARs) containing the γ2 subunit are thought to require the interacting protein GABARAP (GABAAR associated protein) for trafficking to the neuronal plasma membrane. In order to assess whether GABARAP is required for GABAA receptor accumulation at synaptic sites, we analysed a GABARAP knockout mouse. GABARAP deficient mice are
O'Sullivan, G. +3 more
openaire +3 more sources