MBio, 2023 Atg8 family proteins are highly conserved eukaryotic proteins with diverse autophagy and nonautophagic functions in eukaryotes. While the structural features required for conserved autophagy functions of Atg8 are well established, little is known about ...
Thomas R Meister +2 more
exaly +3 more sources
Bioorthogonal Tools for Ethanolamine Lipids and Protein Conjugates. [PDF]
Angew Chem Int Ed EnglAn alkyne‐tagged ethanolamine analog (AlkEA) enables bioorthogonal, metabolic labeling of endogenous phosphatidylethanolamine (PE) and its protein modifications. AlkEA is incorporated into PE via the Kennedy pathway, allowing CuAAC‐based visualization of PE and affinity capture of PE‐conjugated LC3, ubiquitin, and GPI‐anchored proteins.
Cho YT +5 more
europepmc +3 more sources
The BTB/POZ-MATH Protein ZmBPM1 Interacts With Autophagy-related Protein ZmATG6 and Modulates the NLR Protein Rp1-D21-Mediated Defense Response in Maize. [PDF]
Adv Sci (Weinh)The maize BTB/POZ‐MATH (BPM) protein ZmBPM1 interacts with autophagy‐related protein ZmATG6 to relocate the NLR protein Rp1‐D21 from the nucleo‐cytoplasmic compartment into autophagosome‐like puncta, leading to autophagy‐mediated turnover and suppressing the hypersensitive response.
Tang CX +8 more
europepmc +2 more sources
Atg7–Atg12 conjugation and autophagy are negatively regulated by the disordered region of Atg12 [PDF]
Communications BiologyThe macroautophagy/autophagy machinery has two ubiquitin-like (UBL) conjugation systems. The Atg8/MAP1LC3/GABARAP (yeast/human) and Atg12/ATG12 proteins are UBL substrates for Atg7/ATG7, a non-canonical E1 enzyme, that thioesterifies its substrates ...
Hana Popelka, Daniel J. Klionsky
doaj +2 more sources
The Role of ATG8 in Promoting Lipid Accumulation in the Oleaginous Fungus Mucor circinelloides During Nitrogen Limitation [PDF]
Journal of FungiAutophagy is a central cellular process that recycles intracellular components and supplies precursors for biosynthesis. As a key regulator of autophagosome formation, autophagy-related protein 8 (ATG8) plays an essential role in macromolecular ...
Hequn Li +5 more
doaj +2 more sources
MdATG5a-mediated autophagy improves apple performance under low light. [PDF]
Plant JSUMMARY Apples are sun‐loving plants, and excessive canopy closure in orchards leads to poor ventilation and reduced light penetration, ultimately limiting yield and fruit quality. Autophagy is a conserved mechanism for recycling cellular materials and energy in eukaryotes and is known to participate in multiple stress responses.
Xiang W +6 more
europepmc +2 more sources
Atg8-Family Proteins—Structural Features and Molecular Interactions in Autophagy and Beyond
Cells, 2020 Autophagy is a common name for a number of catabolic processes, which keep the cellular homeostasis by removing damaged and dysfunctional intracellular components.
Vladimir Rogov, Vladimir Kirkin
exaly +3 more sources
Ubiquitin and ubiquitin-like modifications in the endoplasmic reticulum stress response. [PDF]
FEBS JEndoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Avril T, Le Gallo M, Lafont E.
europepmc +2 more sources
Atg8ylation as a general membrane stress and remodeling response
Cell Stress, 2021 The yeast Atg8 protein and its paralogs in mammals, mammalian Atg8s (mAtg8s), have been primarily appreciated for their participation in autophagy. However, lipidated mAtg8s, including the most frequently used autophagosomal membrane marker LC3B, are ...
Suresh Kumar, Jingyue Jia1, Vojo Deretic
doaj +1 more source
Dissecting the function of Atg1 complex in Dictyostelium autophagy reveals a connection with the pentose phosphate pathway enzyme transketolase [PDF]
Open Biology, 2015 The network of protein–protein interactions of the Dictyostelium discoideum autophagy pathway was investigated by yeast two-hybrid screening of the conserved autophagic proteins Atg1 and Atg8.
Ana Mesquita +5 more
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