Results 11 to 20 of about 18,950 (216)

Mechanisms and roles of membrane-anchored ATG8s

Frontiers in Cell and Developmental Biology
Autophagy-related protein 8 (ATG8) family proteins, including LC3 and GABARAP subfamilies, are pivotal in canonical autophagy, driving autophagosome formation, cargo selection, and lysosomal fusion.
Soo-Kyeong Lee, Sang-Won Park, Deok-Jin Jang, Jin-A. Lee   +3 more
doaj   +3 more sources

Mechanism of cargo-directed Atg8 conjugation during selective autophagy

eLife, 2016
Selective autophagy is mediated by cargo receptors that link the cargo to the isolation membrane via interactions with Atg8 proteins. Atg8 proteins are localized to the membrane in an ubiquitin-like conjugation reaction, but how this conjugation is ...
Dorotea Fracchiolla, Justyna Sawa-Makarska, Bettina Zens, Anita de Ruiter, Gabriele Zaffagnini, Andrea Brezovich, Julia Romanov, Kathrin Runggatscher, Claudine Kraft, Bojan Zagrovic, Sascha Martens   +10 more
doaj   +5 more sources

The expanding role of Atg8 [PDF]

Autophagy, 2021
It would be quite convenient if every protein had one distinct function, one distinct role in just a single cellular process. In the field of macroautophagy/autophagy, however, we are increasingly finding that this is not the case; several autophagy proteins have two or more roles within the process of autophagy and many even "moonlight" as functional ...
Wayne D. Hawkins, Daniel J. Klionsky
openaire   +2 more sources

A Plant Virus Glycoprotein Induces Autophagy by Activating the Toll7 Immune Pathway in Its Insect Vector. [PDF]

Mol Plant Pathol
The induction of autophagy in Laodelphax striatellus by Rice stripe virus (RSV) glycoprotein through the activation of the Toll7 immune pathway. ABSTRACT The Toll7 pathway is crucial in defending against diverse pathogenic microorganisms, including viruses.
He YJ, Qi YH, Wang C, Jiao GY, Ye ZX, Lin L, Mao QZ, Lu G, Wang XW, Zhang CX, Chen JP, Li JM.   +11 more
europepmc   +2 more sources

Functional Analysis of ATG8 and ATG8-like in Dictyostelium discoideum [PDF]

, 2013
Matthias, Jan
core   +2 more sources

ATI1, a newly identified atg8-interacting protein, binds two different Atg8 homologs [PDF]

Plant Signaling & Behavior, 2012
Autophagy is a mechanism used for the transport of macromolecules to the vacuole for degradation. It can be either non-selective or selective, resulting from the specific binding of target proteins to Atg8, an essential autophagy-related protein. Nine Atg8 homologs exist in the model plant Arabidopsis thaliana, suggesting possible different roles for ...
Tamar, Avin-Wittenberg, Simon, Michaeli, Arik, Honig, Gad, Galili   +3 more
openaire   +2 more sources

Cheating on ubiquitin with Atg8 [PDF]

Autophagy, 2011
Macroautophagy sequesters superflous cytosol and organelles into double-membraned autophagosomes. Over 30 autophagy-related (ATG) genes have been identified without elucidating the molecular details of autophagosome biogenesis. All proposed models for autophagosome formation require membrane fusion events (Fig. 1).
Krick, Roswitha, Bremer, Sebastian, Welter, Evelyn, Eskelinen, Eeva-Liisa, Thumm, Michael   +4 more
openaire   +3 more sources

A nuclear role for Atg8-family proteins [PDF]

Autophagy, 2020
Despite the growing evidence that the macroautophagy/autophagy-related protein LC3 is localized in the nucleus, why and how it is targeted to the nucleus are poorly understood. In our recent study, we found that transcription factor seq (sequoia) interacts via its LIR motif with Atg8a, the Drosophila homolog of LC3, to negatively regulate the ...
Jacomin, Anne-Claire, Petridi, Stavroula, Di Monaco, Marisa, Nezis, Ioannis P.   +3 more
openaire   +3 more sources

New thoughts regarding Atg8 and ubiquitination [PDF]

Autophagy, 2011
Until recently, a clear functional division between the ubiquitin-proteasome system and macroautophagy was common sense. It was thought that ubiquitination targets short-lived or damaged proteins for degradation to the proteasome, whereas macroautophagy nonselectively removes parts of the cytoplasm.
Thumm, Michael, Klionsky, Daniel J.
openaire   +3 more sources

Conserved Atg8 recognition sites mediate Atg4 association with autophagosomal membranes and Atg8 deconjugation [PDF]

EMBO reports, 2017
Deconjugation of the Atg8/LC3 protein family members from phosphatidylethanolamine (PE) by Atg4 proteases is essential for autophagy progression, but how this event is regulated remains to be understood. Here, we show that yeast Atg4 is recruited onto autophagosomal membranes by direct binding to Atg8 via two evolutionarily conserved Atg8 recognition ...
Susana Abreu, Franziska Kriegenburg, Rubén Gómez‐Sánchez, Muriel Mari, Jana Sánchez‐Wandelmer, Mads Skytte Rasmussen, Rodrigo Soares Guimarães, Bettina Zens, Martina Schuschnig, Ralph Hardenberg, Matthias Peter, Terje Johansen, Claudine Kraft, Sascha Martens, Fulvio Reggiori   +14 more
openaire   +5 more sources