Results 11 to 20 of about 429 (86)

Structural biology of the Atg8 and Atg12 conjugation systems

Autophagy Reports, 2023
Atg8 and Atg12 are ubiquitin-like proteins, conjugated to phosphatidylethanolamine (PE) and Atg5, respectively, through enzymatic reactions similar to ubiquitylation.
Nobuo N. Noda
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Distribution, cleavage and lipidation of Atg8 fusion proteins in Spodoptera litura Sl-HP cells.

PLoS ONE, 2014
Atg8 proteins fused with tags are commonly used to detect autophagy. The expression patterns of Lepidopteran insect Atg8 are relatively well documented. However, the influence of protein tags on characterization of Atg8 is still not very clear.
Xiaojuan Zhang, Hongjuan Lu, Hui Ai, Rong Peng, Yongbo Yang, Aiying Li, Huazhu Hong, Jianxin Peng, Kaiyu Liu   +8 more
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Characterization of the autophagy marker protein Atg8 reveals atypical features of autophagy in Plasmodium falciparum. [PDF]

PLoS ONE, 2014
Conventional autophagy is a lysosome-dependent degradation process that has crucial homeostatic and regulatory functions in eukaryotic organisms. As malaria parasites must dispose a number of self and host cellular contents, we investigated if autophagy ...
Rahul Navale, Atul, Aparna Devi Allanki, Puran Singh Sijwali   +3 more
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Lipidation-independent vacuolar functions of Atg8 rely on its noncanonical interaction with a vacuole membrane protein

eLife, 2018
The ubiquitin-like protein Atg8, in its lipidated form, plays central roles in autophagy. Yet, remarkably, Atg8 also carries out lipidation-independent functions in non-autophagic processes. How Atg8 performs its moonlighting roles is unclear.
Xiao-Man Liu, Akinori Yamasaki, Xiao-Min Du, Valerie C Coffman, Yoshinori Ohsumi, Hitoshi Nakatogawa, Jian-Qiu Wu, Nobuo N Noda, Li-Lin Du   +8 more
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AlphaFold2-multimer guided high-accuracy prediction of typical and atypical ATG8-binding motifs

PLoS Biology, 2023
Macroautophagy/autophagy is an intracellular degradation process central to cellular homeostasis and defense against pathogens in eukaryotic cells. Regulation of autophagy relies on hierarchical binding of autophagy cargo receptors and adaptors to ATG8 ...
Tarhan Ibrahim, Virendrasinh Khandare, Federico Gabriel Mirkin, Yasin Tumtas, Doryen Bubeck, Tolga O. Bozkurt   +5 more
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Membrane recruitment of Atg8 by Hfl1 facilitates turnover of vacuolar membrane proteins in yeast cells approaching stationary phase

BMC Biology, 2021
Background The vacuole/lysosome is the final destination of autophagic pathways, but can also itself be degraded in whole or in part by selective macroautophagic or microautophagic processes.
Cheng-Wen He, Xue-Fei Cui, Shao-Jie Ma, Qin Xu, Yan-Peng Ran, Wei-Zhi Chen, Jun-Xi Mu, Hui Li, Jing Zhu, Qingqiu Gong, Zhiping Xie   +10 more
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Infection Dynamics of ATG8 in Leishmania: Balancing Autophagy for Therapeutics

Molecules, 2022
In many regions of the world, Leishmaniasis is a cause of substantial mortality and ailment. Due to impediment in available treatment, development of novel and effective treatments is indispensable.
Vrushali Guhe, Farah Anjum, Alaa Shafie, Md Imtaiyaz Hassan, Visweswara Rao Pasupuleti, Shailza Singh   +5 more
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N-terminal β-strand underpins biochemical specialization of an ATG8 isoform.

PLoS Biology, 2019
Autophagy-related protein 8 (ATG8) is a highly conserved ubiquitin-like protein that modulates autophagy pathways by binding autophagic membranes and a number of proteins, including cargo receptors and core autophagy components.
Erin K Zess, Cassandra Jensen, Neftaly Cruz-Mireles, Juan Carlos De la Concepcion, Jan Sklenar, Madlen Stephani, Richard Imre, Elisabeth Roitinger, Richard Hughes, Khaoula Belhaj, Karl Mechtler, Frank L H Menke, Tolga Bozkurt, Mark J Banfield, Sophien Kamoun, Abbas Maqbool, Yasin F Dagdas   +16 more
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Analysis of Autophagic Activity Using ATG8 Lipidation Assay in Arabidopsis thaliana

Bio-Protocol, 2018
As a fundamental metabolic pathway to degrade and recycle cellular cargos, autophagy is highly induced upon stress, starvation and senescence conditions in plants.
Mengqian Luo, Xiaohong Zhuang
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Biological functions of the autophagy-related proteins Atg4 and Atg8 in Cryptococcus neoformans.

PLoS ONE, 2020
Autophagy is a mechanism responsible for intracellular degradation and recycling of macromolecules and organelles, essential for cell survival in adverse conditions.
Thiago Nunes Roberto, Ricardo Ferreira Lima, Renata Castiglioni Pascon, Alexander Idnurm, Marcelo Afonso Vallim   +4 more
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