Results 11 to 20 of about 11,891 (170)
Structural biology of the Atg8 and Atg12 conjugation systems
Autophagy Reports, 2023 Atg8 and Atg12 are ubiquitin-like proteins, conjugated to phosphatidylethanolamine (PE) and Atg5, respectively, through enzymatic reactions similar to ubiquitylation.
Nobuo N. Noda
doaj +3 more sources
Mechanisms and roles of membrane-anchored ATG8s
Frontiers in Cell and Developmental BiologyAutophagy-related protein 8 (ATG8) family proteins, including LC3 and GABARAP subfamilies, are pivotal in canonical autophagy, driving autophagosome formation, cargo selection, and lysosomal fusion.
Soo-Kyeong Lee +3 more
doaj +3 more sources
Multiple Functions of ATG8 Family Proteins in Plant Autophagy [PDF]
Frontiers in Cell and Developmental Biology, 2020 Autophagy is a major degradation process of cytoplasmic components in eukaryotes, and executes both bulk and selective degradation of targeted cargos.
Fan Bu +6 more
doaj +3 more sources
Role of Atg8 in the regulation of vacuolar membrane invagination [PDF]
Scientific Reports, 2019 Cellular heat stress can cause damage, and significant changes, to a variety of cellular structures. When exposed to chronically high temperatures, yeast cells invaginate vacuolar membranes.
Ayane Ishii +7 more
doaj +3 more sources
ATG8 delipidation is not universally critical for autophagy in plants
Nature Communications, 2023 Intracellular recycling via autophagy is governed by post-translational modifications of the autophagy-related (ATG) proteins. One notable example is ATG4-dependent delipidation of ATG8, a process that plays critical but distinct roles in autophagosome ...
Yong Zou +13 more
doaj +5 more sources
The expanding role of Atg8 [PDF]
Autophagy, 2021 It would be quite convenient if every protein had one distinct function, one distinct role in just a single cellular process. In the field of macroautophagy/autophagy, however, we are increasingly finding that this is not the case; several autophagy proteins have two or more roles within the process of autophagy and many even "moonlight" as functional ...
Wayne D. Hawkins, Daniel J. Klionsky
openaire +2 more sources
Cheating on ubiquitin with Atg8 [PDF]
Autophagy, 2011 Macroautophagy sequesters superflous cytosol and organelles into double-membraned autophagosomes. Over 30 autophagy-related (ATG) genes have been identified without elucidating the molecular details of autophagosome biogenesis. All proposed models for autophagosome formation require membrane fusion events (Fig. 1).
Krick, Roswitha +4 more
openaire +3 more sources
A nuclear role for Atg8-family proteins [PDF]
Autophagy, 2020 Despite the growing evidence that the macroautophagy/autophagy-related protein LC3 is localized in the nucleus, why and how it is targeted to the nucleus are poorly understood. In our recent study, we found that transcription factor seq (sequoia) interacts via its LIR motif with Atg8a, the Drosophila homolog of LC3, to negatively regulate the ...
Jacomin, Anne-Claire +3 more
openaire +3 more sources
ATI1, a newly identified atg8-interacting protein, binds two different Atg8 homologs [PDF]
Plant Signaling & Behavior, 2012 Autophagy is a mechanism used for the transport of macromolecules to the vacuole for degradation. It can be either non-selective or selective, resulting from the specific binding of target proteins to Atg8, an essential autophagy-related protein. Nine Atg8 homologs exist in the model plant Arabidopsis thaliana, suggesting possible different roles for ...
Tamar, Avin-Wittenberg +3 more
openaire +2 more sources
Activation and targeting of ATG8 protein lipidation [PDF]
Cell Discovery, 2020 AbstractATG8 family proteins are evolutionary conserved ubiquitin-like modifiers, which become attached to the headgroup of the membrane lipid phosphatidylethanolamine in a process referred to as lipidation. This reaction is carried out analogous to the conjugation of ubiquitin to its target proteins, involving the E1-like ATG7, the E2-like ATG3 and ...
Martens, Sascha, Fracchiolla, Dorotea
openaire +4 more sources