Results 1 to 10 of about 98,465 (116)

Role of Selective Autophagy in Spermatogenesis and Male Fertility

Cells, 2020
Autophagy is a “self-eating” process that engulfs cellular contents for their subsequent digestion in lysosomes to engage the metabolic need in response to starvation or environmental insults.
Chunyu Lv, Xiaoli Wang, Ying Guo, Shuiqiao Yuan   +3 more
doaj   +3 more sources

The multifaceted functions of selective autophagy in cancer: molecular basis, consequences, and clinical prospects. [PDF]

Mol Cancer
Selective autophagy is a critical cellular process in eukaryotic cells, characterized by the targeted degradation of specific organelles and proteins.
Jiang M, Zhang K, Li M, Tian Y, Wang T, Rodríguez RA, Lin Z, Meng J, Li C, Wang Z, Wu S, Cai Y, Zhang W, Guo R, Liu Y, Bai Y, Lai G, Zhang C, Bo Z, Wei R.   +19 more
europepmc   +2 more sources

Mechanism of autophagy initiation by transmembrane selective autophagy receptors. [PDF]

EMBO J
Selective autophagy ensures the targeted degradation of damaged or surplus cellular components, including organelles, thereby safeguarding cellular homeostasis.
Adriaenssens E, Martens S.
europepmc   +2 more sources

Upregulated pexophagy limits the capacity of selective autophagy. [PDF]

Nat Commun
Selective autophagy is an essential process to maintain cellular homeostasis through the constant recycling of damaged or superfluous components. Over a dozen selective autophagy pathways mediate the degradation of diverse cellular substrates, but ...
Germain K, So RWL, DiGiovanni LF, Watts JC, Bandsma RHJ, Kim PK.   +5 more
europepmc   +2 more sources

Targeting Selective Autophagy as a Therapeutic Strategy for Viral Infectious Diseases

Frontiers in Microbiology, 2022
Autophagy is an evolutionarily conserved lysosomal degradation system which can recycle multiple cytoplasmic components under both physiological and stressful conditions.
Yishan Liu, Tao Zhou, Jiajia Hu, Shouheng Jin, Jianfeng Wu, Xiangdong Guan, Yaoxing Wu, Jun Cui   +7 more
doaj   +1 more source

Emerging mechanistic insights of selective autophagy in hepatic diseases

Frontiers in Pharmacology, 2023
Macroautophagy (hereafter referred to as autophagy), a highly conserved metabolic process, regulates cellular homeostasis by degrading dysfunctional cytosolic constituents and invading pathogens via the lysosomal system.
Abdul Alim Al-Bari, Yuko Ito, Paul G. Thomes, Manoj B. Menon, Marina García-Macia, Raouf Fadel, Alfreda Stadlin, Nicholas Peake, MoezAlIslam Ezzat Faris, Nabil Eid, Daniel J. Klionsky   +10 more
doaj   +1 more source

Oligomerization of Selective Autophagy Receptors for the Targeting and Degradation of Protein Aggregates

Cells, 2021
The selective targeting and disposal of solid protein aggregates are essential for cells to maintain protein homoeostasis. Autophagy receptors including p62, NBR1, Cue5/TOLLIP (CUET), and Tax1-binding protein 1 (TAX1BP1) proteins function in selective ...
Wenjun Chen, Tianyun Shen, Lijun Wang, Kefeng Lu   +3 more
doaj   +1 more source

AeiA, an Atg8-interacting protein in Aspergillus oryzae, promotes peroxisome degradation by pexophagy

Autophagy Reports, 2023
There are two types of autophagy, non-selective (bulk) autophagy, in which substrates are randomly incorporated into autophagosomes, and selective autophagy, in which substrates are specifically targeted.
Takashi Kikuma, Joichiro Nishio
doaj   +1 more source

Role of Macroautophagy in Mammalian Male Reproductive Physiology

Cells, 2023
Physiologically, autophagy is an evolutionarily conserved and self-degradative process in cells. Autophagy carries out normal physiological roles throughout mammalian life.
Doaa Kirat, Ahmed Mohamed Alahwany, Ahmed Hamed Arisha, Adel Abdelkhalek, Taku Miyasho   +4 more
doaj   +1 more source

Herpesvirus Regulation of Selective Autophagy

Viruses, 2021
Selective autophagy has emerged as a key mechanism of quality and quantity control responsible for the autophagic degradation of specific subcellular organelles and materials.
Mai Tram Vo, Young Bong Choi
doaj   +1 more source