Results 1 to 10 of about 1,158,330 (246)

Role of Selective Autophagy in Spermatogenesis and Male Fertility

Cells, 2020
Autophagy is a “self-eating” process that engulfs cellular contents for their subsequent digestion in lysosomes to engage the metabolic need in response to starvation or environmental insults.
Chunyu Lv, Xiaoli Wang, Ying Guo, Shuiqiao Yuan   +3 more
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Oligomerization of Selective Autophagy Receptors for the Targeting and Degradation of Protein Aggregates

Cells, 2021
The selective targeting and disposal of solid protein aggregates are essential for cells to maintain protein homoeostasis. Autophagy receptors including p62, NBR1, Cue5/TOLLIP (CUET), and Tax1-binding protein 1 (TAX1BP1) proteins function in selective ...
Wenjun Chen, Tianyun Shen, Lijun Wang, Kefeng Lu   +3 more
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The multifaceted functions of selective autophagy in cancer: molecular basis, consequences, and clinical prospects [PDF]

Molecular Cancer
Selective autophagy is a critical cellular process in eukaryotic cells, characterized by the targeted degradation of specific organelles and proteins.
Mingyang Jiang, Ke Zhang, Meng Li, Yu Tian, Tao Wang, Raquel Alarcón Rodríguez, Zhanghui Lin, Jinfeng Meng, Chenghao Li, Zheng Wang, Sichang Wu, Yunfei Cai, Wenyang Zhang, Rui Guo, Yao Liu, Yuqi Bai, Guichuan Lai, Chengcheng Zhang, Zhandong Bo, Ruqiong Wei   +19 more
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Autophagy and selective autophagy receptors: Key players against Alzheimer’s disease [PDF]

Neural Regeneration Research
The devastating neurodegenerative disorder of Alzheimer’s disease hallmarks the presence of protein aggregates known as amyloid-β plaques and neurofibrillary tangles, composed of amyloid-β peptides and aberrantly phosphorylated Tau protein, respectively.
Krenare Bruqi, Flavie Strappazzon
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Targeting selective autophagy and beyond: From underlying mechanisms to potential therapies

Journal of Advanced Research
Background: Autophagy is an evolutionarily conserved turnover process for intracellular substances in eukaryotes, relying on lysosomal (in animals) or vacuolar (in yeast and plants) mechanisms.
Wei Ma, Yingying Lu, Xin Jin, Na Lin, Lan Zhang, Yaowen Song   +5 more
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Mechanism of autophagy initiation by transmembrane selective autophagy receptors [PDF]

The EMBO Journal
Selective autophagy ensures the targeted degradation of damaged or surplus cellular components, including organelles, thereby safeguarding cellular homeostasis.
Elias Adriaenssens, Sascha Martens
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Targeting Selective Autophagy as a Therapeutic Strategy for Viral Infectious Diseases

Frontiers in Microbiology, 2022
Autophagy is an evolutionarily conserved lysosomal degradation system which can recycle multiple cytoplasmic components under both physiological and stressful conditions.
Yishan Liu, Tao Zhou, Jiajia Hu, Shouheng Jin, Jianfeng Wu, Xiangdong Guan, Yaoxing Wu, Jun Cui   +7 more
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Emerging mechanistic insights of selective autophagy in hepatic diseases

Frontiers in Pharmacology, 2023
Macroautophagy (hereafter referred to as autophagy), a highly conserved metabolic process, regulates cellular homeostasis by degrading dysfunctional cytosolic constituents and invading pathogens via the lysosomal system.
Abdul Alim Al-Bari, Yuko Ito, Paul G. Thomes, Manoj B. Menon, Marina García-Macia, Raouf Fadel, Alfreda Stadlin, Nicholas Peake, MoezAlIslam Ezzat Faris, Nabil Eid, Daniel J. Klionsky   +10 more
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AeiA, an Atg8-interacting protein in Aspergillus oryzae, promotes peroxisome degradation by pexophagy

Autophagy Reports, 2023
There are two types of autophagy, non-selective (bulk) autophagy, in which substrates are randomly incorporated into autophagosomes, and selective autophagy, in which substrates are specifically targeted.
Takashi Kikuma, Joichiro Nishio
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Herpesvirus Regulation of Selective Autophagy

Viruses, 2021
Selective autophagy has emerged as a key mechanism of quality and quantity control responsible for the autophagic degradation of specific subcellular organelles and materials.
Mai Tram Vo, Young Bong Choi
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