Results 21 to 30 of about 98,515 (154)
Cells, 2021 Nuclear autophagy is an important selective autophagy process. The selective autophagy of sexual development micronuclei (MICs) and the programmed nuclear degradation of parental macronucleus (paMAC) occur during sexual reproduction in Tetrahymena ...
Tao Bo +4 more
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Selective autophagy controls innate immune response through a TAK1/TAB2/SH3PX1 axis
Cell Reports, 2022 Summary: Selective autophagy is a catabolic route that turns over specific cellular material for degradation by lysosomes, and whose role in the regulation of innate immunity is largely unexplored.
Panagiotis Tsapras +7 more
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A Role for Ubiquitin in Selective Autophagy [PDF]
Molecular Cell, 2009 Ubiquitination is the hallmark of protein degradation by the 26S proteasome. However, the proteasome is limited in its capacity to degrade oligomeric and aggregated proteins. Removal of harmful protein aggregates is mediated by autophagy, a mechanism by which the cell sequesters cytosolic cargo and delivers it for degradation by the lysosome ...
Kirkin, Vladimir +3 more
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The role of OFD1 in selective autophagy [PDF]
Molecular & Cellular Oncology, 2021 Autophagy is a cellular self-degradative pathway. Our study unveiled a novel mechanism mediated by OFD1, the protein mutated in Oral-Facial-Digital type I syndrome, based on selective degradation of autophagic proteins, which enables cells to calibrate their self-degradation.
Franco B., Morleo M.
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Selective Autophagy by Close Encounters of the Ubiquitin Kind
Cells, 2020 Autophagy, a bulk degradation process within eukaryotic cells, is responsible for cellular turnover and nutrient liberation during starvation. Increasing evidence indicate that this process can be extremely discerning.
Anna Vainshtein, Paolo Grumati
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CALCOCO1 in the progression of malignant tumors [PDF]
Jichu yixue yu linchuang, 2023 Calcium binding and coiled-coil domain 1 (CALCOCO1) is an autophagy regulatory protein being discovered in recent years, which plays an important role in selective autophagy process.
JIA Nan, WANG Zhilian
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mBio, 2021 Mycobacterium tuberculosis (Mtb) causes one of the deadliest infectious diseases worldwide. Upon infection, Mtb is phagocytosed by macrophages and uses its virulence-associated ESX-1 secretion system to modulate the host cell.
Samantha L. Bell +4 more
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Pexophagy: A Model for Selective Autophagy [PDF]
International Journal of Molecular Sciences, 2020 The removal of damaged or superfluous organelles from the cytosol by selective autophagy is required to maintain organelle function, quality control and overall cellular homeostasis. Precisely how substrate selectivity is achieved, and how individual substrates are degraded during selective autophagy in response to both extracellular and intracellular ...
Germain, Kyla, Kim, Peter K.
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Viruses, 2021 Selective autophagy mediates the degradation of cytoplasmic cargos, such as damaged organelles, invading pathogens, and protein aggregates. However, whether it targets double-stranded RNA (dsRNA) of intracellular pathogens is still largely unknown. Here,
Chenyang Xu +5 more
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Mechanisms of Selective Autophagy
Journal of Molecular Biology, 2016 Selective autophagy contributes to intracellular homeostasis by mediating the degradation of cytoplasmic material such as aggregated proteins, damaged or over-abundant organelles, and invading pathogens. The molecular machinery for selective autophagy must ensure efficient recognition and sequestration of the cargo within autophagosomes.
Gabriele Zaffagnini, Sascha Martens
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