Results 21 to 30 of about 166,195 (340)
Cancer Science, 2021 AbstractWhile starvation‐induced autophagy is thought to randomly degrade cellular components, under certain circumstances autophagy selectively recognizes, sequesters, and degrades specific targets via autophagosomes. This process is called selective autophagy, and it contributes to cellular homeostasis by degrading specific soluble proteins ...
Mohammad Omar Faruk +2 more
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NBR1: The archetypal selective autophagy receptor [PDF]
Journal of Cell Biology, 2022 NBR1 was discovered as an autophagy receptor not long after the first described vertebrate autophagy receptor p62/SQSTM1. Since then, p62 has currently been mentioned in >10,000 papers on PubMed, while NBR1 is mentioned in <350 papers. Nonetheless, evolutionary analysis reveals that NBR1, and likely also selective autophagy, was present ...
Nikoline Lander Rasmussen +3 more
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The Roles of SQSTM1/p62 in Selective Autophagy and Oncogenic Signaling [PDF]
Int J Mol SciYoung-Jun Kim +5 more
europepmc +3 more sources
Selective autophagy as the basis of autophagy-based degraders [PDF]
Cell Chemical Biology, 2021 Degrader technologies, which enable the chemical knockdown of disease-causing proteins, are promising for drug discovery. After two decades of research, degraders using the ubiquitin-proteasome system (UPS) are currently in clinical trials. However, the UPS substrates are mainly limited to soluble proteins.
Daiki Takahashi, Hirokazu Arimoto
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Mechanisms of Selective Autophagy
Annual Review of Cell and Developmental Biology, 2021 Selective autophagy is the lysosomal degradation of specific intracellular components sequestered into autophagosomes, late endosomes, or lysosomes through the activity of selective autophagy receptors (SARs). SARs interact with autophagy-related (ATG)8 family proteins via sequence motifs called LC3-interacting region (LIR) motifs in vertebrates and ...
Lamark, Trond, Johansen, Terje
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Targeting Selective Autophagy as a Therapeutic Strategy for Viral Infectious Diseases
Frontiers in Microbiology, 2022 Autophagy is an evolutionarily conserved lysosomal degradation system which can recycle multiple cytoplasmic components under both physiological and stressful conditions.
Yishan Liu +7 more
doaj +1 more source
Selective autophagy fine-tunes Stat92E activity by degrading Su(var)2-10/PIAS in <i>Drosophila</i> glia. [PDF]
Life Sci AllianceVincze V +9 more
europepmc +2 more sources
Selective autophagy: Lysophagy [PDF]
Methods, 2015 Autophagy is a bulk degradation system that is induced under stress conditions such as nutrient deprivation. Selective autophagy, including xenophagy and mitophagy, is believed to play important roles in the development of several diseases. Consequently, selective autophagy represents a potential therapeutic target. Recent work showed that the lysosome,
Junya, Hasegawa +3 more
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Emerging mechanistic insights of selective autophagy in hepatic diseases
Frontiers in Pharmacology, 2023 Macroautophagy (hereafter referred to as autophagy), a highly conserved metabolic process, regulates cellular homeostasis by degrading dysfunctional cytosolic constituents and invading pathogens via the lysosomal system.
Abdul Alim Al-Bari +10 more
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Selective Types of Autophagy [PDF]
International Journal of Cell Biology, 2012 The focus of this special issue of the International Journal of Cell Biology is to underscore the recent developments in the field of macroautophagy and how this degradative pathway intersects with cellular metabolism, complex physiological functions, and human diseases. During the last decade, autophagy has become an expanding field in biomedical life
Fulvio Reggiori +3 more
doaj +3 more sources