Results 41 to 50 of about 98,515 (154)
Implications of Therapy-Induced Selective Autophagy on Tumor Metabolism and Survival
International Journal of Cell Biology, 2012 Accumulating evidence indicates that therapies designed to trigger apoptosis in tumor cells cause mitochondrial depolarization, nuclear damage, and the accumulation of misfolded protein aggregates, resulting in the activation of selective forms of ...
Luke R. K. Hughson +3 more
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Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives
Molecular CancerEukaryotic cells engage in autophagy, an internal process of self-degradation through lysosomes. Autophagy can be classified as selective or non-selective depending on the way it chooses to degrade substrates.
Jiaxi Liu +8 more
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Selective autophagy in budding yeast [PDF]
Cell Death & Differentiation, 2012 Autophagy is a bulk degradation system, widely conserved in eukaryotes. Upon starvation, autophagosomes enclose a portion of the cytoplasm and ultimately fuse with the vacuole. The contents of autophagosomes are degraded in the vacuole, and recycled to maintain the intracellular amino-acid pool required for protein synthesis and survival under ...
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Selective types of autophagy in yeast
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009 Autophagy is the process through which cytosol and organelles are sequestered into a double-membrane vesicle called an autophagosome and delivered to the vacuole/lysosome for breakdown and recycling. One of its primary roles in unicellular organisms is to regulate intracellular homeostasis and to adjust organelle numbers in response to stress such as ...
Kraft, Claudine +2 more
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Broad and Complex Roles of NBR1-Mediated Selective Autophagy in Plant Stress Responses
Cells, 2020 Selective autophagy is a highly regulated degradation pathway for the removal of specific damaged or unwanted cellular components and organelles such as protein aggregates.
Yan Zhang, Zhixiang Chen
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Vps13 is Required for Efficient Autophagy in
Contact, 2022 Vps13 is a large, conserved protein that transports lipids between membranes. Its localization at multiple organelle membranes and membrane contact sites suggests its important physiological roles.
Yuchen Lei, Xin Wen, Daniel J Klionsky
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Pexophagy: The Selective Autophagy of Peroxisomes [PDF]
Autophagy, 2005 Pichia pastoris and Hansenula polymorpha are methylotrophic yeasts capable of utilizing methanol, as a sole source of carbon and energy. Growth of these yeast species on methanol requires the synthesis of cytosolic and peroxisomal enzymes combined with the proliferation of peroxisomes.
Dunn, Jr. +8 more
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PLoS Pathogens, 2019 Mycobacterial pathogens are the causative agents of chronic infectious diseases like tuberculosis and leprosy. Autophagy has recently emerged as an innate mechanism for defense against these intracellular pathogens.
Rui Zhang +5 more
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Membrane Contact Sites and Organelles Interaction in Plant Autophagy
Frontiers in Plant Science, 2020 Autophagy is an intracellular trafficking and degradation system for recycling of damaged organelles, mis-folded proteins and cytoplasmic constituents. Autophagy can be divided into non-selective autophagy and selective autophagy according to the cargo ...
Hao Ye +5 more
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Multiple Functions of ATG8 Family Proteins in Plant Autophagy
Frontiers in Cell and Developmental Biology, 2020 Autophagy is a major degradation process of cytoplasmic components in eukaryotes, and executes both bulk and selective degradation of targeted cargos.
Fan Bu +6 more
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