Results 51 to 60 of about 166,195 (340)
The aberrant expression of the mesenchymal variant of FGFR2 in the epithelial context inhibits autophagy [PDF]
, 2019 Signaling of the epithelial splice variant of fibroblast growth factor receptor 2 (FGFR2b) triggers both differentiation and autophagy, while the aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells induces impaired differentiation ...
Belleudi, Francesca +4 more
core +1 more source
The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. [PDF]
, 2018 Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome ...
Alnemri, Emad S. +9 more
core +4 more sources
Autophagic flux is required for the synthesis of triacylglycerols and ribosomal protein turnover in Chlamydomonas [PDF]
, 2018 Autophagy is an intracellular catabolic process that allows cells to recycle unneeded or damaged material to maintain cellular homeostasis. This highly dynamic process is characterized by the formation of double-membrane vesicles called autophagosomes ...
Couso Liáñez, Inmaculada Concepción +4 more
core +1 more source
Autophagy selectively regulates miRNA homeostasis [PDF]
Autophagy, 2013 MicroRNAs (miRNAs) form a class of ~21 nucleotide (nt) RNAs that post-transcriptionally repress partially complementary messenger RNAs. miRNA-mediated silencing is critical for control of many key biological processes such as tumorigenesis, neuronal synaptic plasticity and defense against bacteria and viruses.
Gibbings, D., Mostowy, S., Voinnet, O.
openaire +3 more sources
Life, 2022 Glycogen storage diseases (GSDs) are rare metabolic monogenic disorders characterized by an excessive accumulation of glycogen in the cell. However, monogenic disorders are not simple regarding genotype–phenotype correlation.
Marina Andjelkovic +6 more
doaj +1 more source
Mechanisms of Selective Autophagy
Journal of Molecular Biology, 2016 Selective autophagy contributes to intracellular homeostasis by mediating the degradation of cytoplasmic material such as aggregated proteins, damaged or over-abundant organelles, and invading pathogens. The molecular machinery for selective autophagy must ensure efficient recognition and sequestration of the cargo within autophagosomes.
Gabriele Zaffagnini, Sascha Martens
openaire +3 more sources
Molecular mechanisms of selective autophagy [PDF]
Cell Death & Differentiation, 2012 Autophagy is the catabolic process by which the cell degrades cytoplasmic components within lysosomes.1 The balance between the biosynthesis of cellular components and their eventual degradation is of cardinal importance for normal cellular homeostasis and health.2 Autophagy has long been thought to be an essential but non-selective bulk degradation ...
FIMIA, Gian Maria +2 more
openaire +5 more sources
Frontiers in Plant Science, 2021 Salt stress is an adverse environmental factor for plant growth and development. Under salt stress, plants can activate the selective autophagy pathway to alleviate stress.
Wanlong Su +29 more
doaj +1 more source
FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates [PDF]
, 2019 The autophagy cargo receptor p62 facilitates the condensation of misfolded, ubiquitin-positive proteins and their degradation by autophagy, but the molecular mechanism of p62 signaling to the core autophagy machinery is unclear.
Abert, Christine +9 more
core +1 more source
Implications of Selective Autophagy Dysfunction for ALS Pathology
Cells, 2020 Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. Due to the biological complexity of the disease, its etiology remains unknown.
Emiliano Vicencio +5 more
doaj +1 more source