Results 51 to 60 of about 1,158,330 (246)

Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of leishmania major [PDF]

, 2013
Macroautophagy in Leishmania, which is important for the cellular remodeling required during differentiation, relies upon the hydrolytic activity of two ATG4 cysteine peptidases (ATG4.1 and ATG4.2).
Coombs, G.H., Williams, Roderick A M, Mottram, Jeremy C, Williams, R.A.M, Coombs, Graham H, Mottram, J.C., Jeremy C. Mottram, Graham H. Coombs, Roderick A.M. Williams   +8 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The selective autophagy receptors Optineurin and p62 are both required for zebrafish host resistance to mycobacterial infection.

PLoS Pathogens, 2019
Mycobacterial pathogens are the causative agents of chronic infectious diseases like tuberculosis and leprosy. Autophagy has recently emerged as an innate mechanism for defense against these intracellular pathogens.
Rui Zhang, Monica Varela, Wies Vallentgoed, Gabriel Forn-Cuni, Michiel van der Vaart, Annemarie H Meijer   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Vps13 is Required for Efficient Autophagy in

Contact, 2022
Vps13 is a large, conserved protein that transports lipids between membranes. Its localization at multiple organelle membranes and membrane contact sites suggests its important physiological roles.
Yuchen Lei, Xin Wen, Daniel J Klionsky
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Elastase induces lung epithelial cell autophagy through placental growth factor A new insight of emphysema pathogenesis

, 2017
Chronic obstructive pulmonary disease (COPD) is a devastating disease, which is associated with increasing mortality and morbidity. Therefore, there is a need to clearly define the COPD pathogenic mechanism and to explore effective therapies.
Hou, Hsin-Han;Cheng, Shih-Lung;Chung, Kuei-Pin;Kuo, Mark Yen-Ping;Yeh, Cheng-Chang;Chang, Bei-En;Lu, Hsuan-Hsuan;Wang, Hao-Chien;Yu, Chong-Jen, 王鶴健;張百恩;余忠仁;郭彥彬;鐘桂彬   +1 more
core   +1 more source

MIR376A is a regulator of starvation-induced autophagy [PDF]

, 2013
Background: Autophagy is a vesicular trafficking process responsible for the degradation of long-lived, misfolded or abnormal proteins, as well as damaged or surplus organelles.
Gozuacik Devrim, Ali Kosar, Korkmaz Gozde, Devrim Gozuacik (498143), Kosar Ali, Gözüaçık, Devrim, Gozuacik, Devrim, Kumsal Ayse Tekirdag (498140), Koşar, Ali, Sezerman, Uğur, Gozde Korkmaz, Ozturk Deniz Gulfem, Gozde Korkmaz (498139), Deniz Gulfem Ozturk, Osman Ugur Sezerman (199388), Sezerman, Osman Ugur, Tekirdag Kumsal Ayse, Korkmaz, Gözde, Tekirdağ, Kumsal Ayşe, Osman Ugur Sezerman, Deniz Gulfem Ozturk (498141), Sezerman Osman Ugur, Özturk, Deniz Gülfem, Kumsal Ayse Tekirdag, Devrim Gozuacik, Ali Kosar (498142)   +25 more
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Membrane Contact Sites and Organelles Interaction in Plant Autophagy

Frontiers in Plant Science, 2020
Autophagy is an intracellular trafficking and degradation system for recycling of damaged organelles, mis-folded proteins and cytoplasmic constituents. Autophagy can be divided into non-selective autophagy and selective autophagy according to the cargo ...
Hao Ye, Changyang Ji, Rongfang Guo, Rongfang Guo, Liwen Jiang, Liwen Jiang   +5 more
doaj   +1 more source