Results 51 to 60 of about 98,515 (154)
PLoS ONE, 2015 Macroautophagy is a highly regulated intracellular degradation process which has been extensively studied over the last decade. This pathway has been initially described as a non selective process inducing the degradation of parts of the cytoplasm as ...
Thierry Gauthier +4 more
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A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway [PDF]
Molecular Cell, 2019 The clearance of surplus, broken, or dangerous components is key for maintaining cellular homeostasis. The failure to remove protein aggregates, damaged organelles, or intracellular pathogens leads to diseases, including neurodegeneration, cancer, and infectious diseases.
Kirkin, Vladimir, Rogov, Vladimir V.
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Glycogen Granules Are Degraded by Non-Selective Autophagy in Nitrogen-Starved Komagataella phaffii
CellsAutophagy was initially recognized as a bulk degradation process that randomly sequesters and degrades cytoplasmic material in lysosomes (vacuoles in yeast). In recent years, various types of selective autophagy have been discovered.
Nimna V. Wijewantha +2 more
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Autophagy: Shedding Light on the Mechanisms and Multifaceted Roles in Cancers
BiomoleculesAutophagy, an evolutionarily conserved self-degradation catabolic mechanism, is crucial for recycling breakdown products and degrading intracellular components such as cytoplasmic organelles, macromolecules, and proteins in eukaryotes. The process, which
Hongmei You +4 more
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PLoS BiologyDefective autophagy is linked to proinflammatory diseases. However, the mechanisms by which autophagy limits inflammation remain elusive. Here, we found that the pan-FGFR inhibitor LY2874455 efficiently activated autophagy and suppressed expression of ...
Jiao Zhou +6 more
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Autophagy of glycogen is non-selective in Komagataella phaffii
Autophagy ReportsGlycogen is an important reserve polysaccharide from bacteria to human. It is organized in glycogen granules that also contain several proteins involved in their metabolism.
Taras Y. Nazarko
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Zymophagy: Selective Autophagy of Secretory Granules [PDF]
International Journal of Cell Biology, 2012 Timing is everything. That's especially true when it comes to the activation of enzymes created by the pancreas to break down food. Pancreatic enzymes are packed in secretory granules as precursor molecules called zymogens. In physiological conditions, those zymogens are activated only when they reach the gut, where they get to work releasing and ...
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Nature Communications, 2017 Selective autophagy describes the selective degradation of cellular components upon stress or nutrient deficiency, but whether it modulates innate immunity is unclear.
Radu Tusco +6 more
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Compromised autophagy in the aging epididymis: Evidence and relevance to male fertility
Experimental GerontologyImpaired autophagy and increased cellular senescence in the aging epididymis may lead to cellular stress, inflammation, and epithelial dysfunction. This reduction in autophagy can be identified using light and electron microscopy, as well as molecular ...
Nabil Eid
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Plant StressRoot-knot nematodes (RKNs; Meloidogyne incognita) are recognized as the most destructive plant pathogenic nematodes, posing a significant threat to global food security.
Ting Yang +6 more
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