Results 31 to 40 of about 98,515 (154)

The emerging role of autophagy and mitophagy in tauopathies: From pathogenesis to translational implications in Alzheimer’s disease

Frontiers in Aging Neuroscience, 2022
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease, affecting more than 55 million individuals worldwide in 2021. In addition to the “amyloid hypothesis,” an increasing number of studies have demonstrated that phosphorylated tau ...
Xiaolan Liu, Xiaolan Liu, Meng Ye, Meng Ye, Liang Ma, Liang Ma   +5 more
doaj   +1 more source

SnapShot: Selective Autophagy

Cell, 2013
There are various types of autophagy, which can be categorized as nonselective or selective. Macroautophagy is an evolutionarily conserved process through which cells degrade and recycle cytoplasm. Nonselective macroautophagy randomly engulfs a portion of the cytoplasm into autophagosomes and then delivers them to the vacuole (in fungi or plants) or ...
Jin, Meiyan, Liu, Xu, Klionsky, Daniel J.   +2 more
openaire   +2 more sources

Crosstalk between Glycogen-Selective Autophagy, Autophagy and Apoptosis as a Road towards Modifier Gene Discovery and New Therapeutic Strategies for Glycogen Storage Diseases

Life, 2022
Glycogen storage diseases (GSDs) are rare metabolic monogenic disorders characterized by an excessive accumulation of glycogen in the cell. However, monogenic disorders are not simple regarding genotype–phenotype correlation.
Marina Andjelkovic, Anita Skakic, Milena Ugrin, Vesna Spasovski, Kristel Klaassen, Sonja Pavlovic, Maja Stojiljkovic   +6 more
doaj   +1 more source

Selective Autophagy: Talking with the UPS [PDF]

Cell Biochemistry and Biophysics, 2013
Far from now are the days when investigators raced to identify the proteolytic system responsible for the degradation of their favorite protein. Nowadays, it is well accepted that a given protein can be degraded by different systems depending on factors such as cell type, cellular conditions, or functionality of each proteolytic pathway.
Caroline, Park, Ana Maria, Cuervo
openaire   +2 more sources

Poplar Autophagy Receptor NBR1 Enhances Salt Stress Tolerance by Regulating Selective Autophagy and Antioxidant System

Frontiers in Plant Science, 2021
Salt stress is an adverse environmental factor for plant growth and development. Under salt stress, plants can activate the selective autophagy pathway to alleviate stress.
Wanlong Su, Wanlong Su, Wanlong Su, Yu Bao, Yu Bao, Yu Bao, Yingying Lu, Yingying Lu, Yingying Lu, Fang He, Fang He, Fang He, Shu Wang, Shu Wang, Shu Wang, Dongli Wang, Dongli Wang, Dongli Wang, Xiaoqian Yu, Xiaoqian Yu, Xiaoqian Yu, Weilun Yin, Weilun Yin, Weilun Yin, Xinli Xia, Xinli Xia, Xinli Xia, Chao Liu, Chao Liu, Chao Liu   +29 more
doaj   +1 more source

Implications of Selective Autophagy Dysfunction for ALS Pathology

Cells, 2020
Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. Due to the biological complexity of the disease, its etiology remains unknown.
Emiliano Vicencio, Sebastián Beltrán, Luis Labrador, Patricio Manque, Melissa Nassif, Ute Woehlbier   +5 more
doaj   +1 more source

Emerging role of selective autophagy in human diseases.

Frontiers in Pharmacology, 2014
Autophagy was originally described as a highly conserved system for the degradation of cytosol through a lysosome-dependent pathway. In response to starvation, autophagy degrades organelles and proteins to provide metabolites and energy for its pro ...
Kenji eMizumura, Augustine M.K. Choi, Stefan W. Ryter   +2 more
doaj   +1 more source

Targeting selective autophagy and beyond: From underlying mechanisms to potential therapies

Journal of Advanced Research
Background: Autophagy is an evolutionarily conserved turnover process for intracellular substances in eukaryotes, relying on lysosomal (in animals) or vacuolar (in yeast and plants) mechanisms.
Wei Ma, Yingying Lu, Xin Jin, Na Lin, Lan Zhang, Yaowen Song   +5 more
doaj   +1 more source

Ubiquitin, Autophagy and Neurodegenerative Diseases

Cells, 2020
Ubiquitin signals play various roles in proteolytic and non-proteolytic functions. Ubiquitin signals are recognized as targets of the ubiquitin–proteasome system and the autophagy–lysosome pathway.
Yoshihisa Watanabe, Katsutoshi Taguchi, Masaki Tanaka   +2 more
doaj   +1 more source

Molecular mechanisms of selective autophagy [PDF]

Cell Death & Differentiation, 2012
Autophagy is the catabolic process by which the cell degrades cytoplasmic components within lysosomes.1 The balance between the biosynthesis of cellular components and their eventual degradation is of cardinal importance for normal cellular homeostasis and health.2 Autophagy has long been thought to be an essential but non-selective bulk degradation ...
FIMIA, Gian Maria, G. Kroemer, M. Piacentini   +2 more
openaire   +5 more sources