Results 31 to 40 of about 1,158,330 (246)

The Autophagy Cargo Receptor SQSTM1 Inhibits Infectious Bursal Disease Virus Infection through Selective Autophagic Degradation of Double-Stranded Viral RNA

Viruses, 2021
Selective autophagy mediates the degradation of cytoplasmic cargos, such as damaged organelles, invading pathogens, and protein aggregates. However, whether it targets double-stranded RNA (dsRNA) of intracellular pathogens is still largely unknown. Here,
Chenyang Xu, Tongtong Li, Jing Lei, Yina Zhang, Jiyong Zhou, Boli Hu   +5 more
doaj   +1 more source

Time flies : autophagy during ageing in Drosophila [PDF]

, 2013
The process of ageing compromises the age-associated decrease in fertility, gradual loss of function, and increased vulnerability to disease, which progressively diminishes the capability of an organism to survive [1-3]. Unsurprisingly, in the past years
Nezis, I. P., Andreas Brech, Brech, Andreas, Shultz, Sebastian Wolfgang, Ioannis P., Sebastian Wolfgang   +5 more
core   +1 more source

Quantitative Phosphoproteomics of Selective Autophagy Receptors

, 2022
S.691-701Selective autophagy enables degradation of specific cargo such as protein aggregates or organelles and thus plays an essential role in the regulation of cellular homeostasis. Cargo specificity is achieved on the level of autophagy receptors that
Dikic, I., Beli, P., Juretschke, T.
core   +1 more source

Autophagy: A Forty-Year Search for a Missing Membrane Source [PDF]

, 2006
Autophagy is the major self-degradative process in eukaryotic cells, with fundamental roles in cellular and organismal homeostasis, and is involved in many developmental and pathological situations.
Juhasz Gabor, Neufeld, Thomas P., Neufeld Thomas P, Gabor Juhasz, Juhász, Gábor, Thomas P Neufeld   +5 more
core   +2 more sources

The emerging role of autophagy and mitophagy in tauopathies: From pathogenesis to translational implications in Alzheimer’s disease

Frontiers in Aging Neuroscience, 2022
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease, affecting more than 55 million individuals worldwide in 2021. In addition to the “amyloid hypothesis,” an increasing number of studies have demonstrated that phosphorylated tau ...
Xiaolan Liu, Xiaolan Liu, Meng Ye, Meng Ye, Liang Ma, Liang Ma   +5 more
doaj   +1 more source

Poplar Autophagy Receptor NBR1 Enhances Salt Stress Tolerance by Regulating Selective Autophagy and Antioxidant System

Frontiers in Plant Science, 2021
Salt stress is an adverse environmental factor for plant growth and development. Under salt stress, plants can activate the selective autophagy pathway to alleviate stress.
Wanlong Su, Wanlong Su, Wanlong Su, Yu Bao, Yu Bao, Yu Bao, Yingying Lu, Yingying Lu, Yingying Lu, Fang He, Fang He, Fang He, Shu Wang, Shu Wang, Shu Wang, Dongli Wang, Dongli Wang, Dongli Wang, Xiaoqian Yu, Xiaoqian Yu, Xiaoqian Yu, Weilun Yin, Weilun Yin, Weilun Yin, Xinli Xia, Xinli Xia, Xinli Xia, Chao Liu, Chao Liu, Chao Liu   +29 more
doaj   +1 more source

Selective autophagy mediated by autophagic adapter proteins [PDF]

, 2011
Mounting evidence suggests that autophagy is a more selective process than originally anticipated. The discovery and characterization of autophagic adapters, like p62 and NBR1, has provided mechanistic insight into this process.
Lamark, Trond, Trond Lamark, Terje Johansen, Johansen, Terje   +3 more
core   +1 more source

Crosstalk between Glycogen-Selective Autophagy, Autophagy and Apoptosis as a Road towards Modifier Gene Discovery and New Therapeutic Strategies for Glycogen Storage Diseases

Life, 2022
Glycogen storage diseases (GSDs) are rare metabolic monogenic disorders characterized by an excessive accumulation of glycogen in the cell. However, monogenic disorders are not simple regarding genotype–phenotype correlation.
Marina Andjelkovic, Anita Skakic, Milena Ugrin, Vesna Spasovski, Kristel Klaassen, Sonja Pavlovic, Maja Stojiljkovic   +6 more
doaj   +1 more source

Emerging role of selective autophagy in human diseases.

Frontiers in Pharmacology, 2014
Autophagy was originally described as a highly conserved system for the degradation of cytosol through a lysosome-dependent pathway. In response to starvation, autophagy degrades organelles and proteins to provide metabolites and energy for its pro ...
Kenji eMizumura, Augustine M.K. Choi, Stefan W. Ryter   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source