NBR1-Mediated Selective Autophagy in Plant Development and Stress Responses [PDF]
PlantsAutophagy is a conserved degradation pathway essential for cellular homeostasis in plants. Selective autophagy confers cargo specificity through receptors, among which NEIGHBOR OF BRCA1 GENE1 (NBR1) is one of the best-characterized.
Xinye Li +3 more
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Broad and Complex Roles of NBR1-Mediated Selective Autophagy in Plant Stress Responses
Cells, 2020 Selective autophagy is a highly regulated degradation pathway for the removal of specific damaged or unwanted cellular components and organelles such as protein aggregates.
Yan Zhang +2 more
exaly +3 more sources
Heat shock protein A1L restricts influenza A virus by ubiquitination of NA [PDF]
Journal of VirologyNeuraminidase (NA) protein of influenza A virus (IAV), a tetrameric envelope glycoprotein critical for viral release and spread, has well-characterized enzymatic functions but poorly resolved host-pathogen interactions.
Yan Yan +11 more
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Mechanical signal modulates prostate cancer immune escape by USP8-mediated ubiquitination-dependent degradation of PD-L1 and MHC-1 [PDF]
Cell Death and DiseaseThe tumor environment of prostate cancer (PCa) tissues of high Gleason score has been proved to be more immune suppressive and has higher extracellular matrix (ECM) stiffness, but whether ECM mechanical stiffness is the cause of higher ability of ...
Zhi-Bin Ke +12 more
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Evaluation of aggrephagy markers in myofibrillar myopathies [PDF]
Acta Neuropathologica CommunicationsMyofibrillar Myopathies (MFMs) are a growing group of muscular disorders genetically determined, whose diagnosis is based on histological features as myofibrillar degeneration, Z-disk disorganization and protein aggregates’ accumulation.
Eliana Iannibelli +21 more
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NBR1-mediated selective autophagy of ARF7 modulates root branching
EMBO ReportsAuxin dictates root architecture via the Auxin Response Factor (ARF) family of transcription factors, which control lateral root (LR) formation. In Arabidopsis, ARF7 regulates the specification of prebranch sites (PBS) generating LRs through gene ...
Elise Ebstrup +2 more
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The autophagy receptor NBR1 directs the clearance of photodamaged chloroplasts
eLife, 2023 The ubiquitin-binding NBR1 autophagy receptor plays a prominent role in recognizing ubiquitylated protein aggregates for vacuolar degradation by macroautophagy.
Han Nim Lee +9 more
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Structural mechanism of protein recognition by the FW domain of autophagy receptor Nbr1
Nature Communications, 2022 Nbr1 recognizes cargos in selective autophagy. Here, authors show filamentous yeast Nbr1 binds Ams1 via an FW domain, and the cryo-EM structure reveals that Nbr1 recognizes the N-terminal di-glycine and tetrameric assembly of Ams1.
Jianxiu Zhang +6 more
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E3 ubiquitin ligase CHIP and NBR1-mediated selective autophagy protect additively against proteotoxicity in plant stress responses. [PDF]
PLoS Genetics, 2014 Plant stress responses require both protective measures that reduce or restore stress-inflicted damage to cellular structures and mechanisms that efficiently remove damaged and toxic macromolecules, such as misfolded and damaged proteins.
Jie Zhou +6 more
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NBR1-mediated selective autophagy targets insoluble ubiquitinated protein aggregates in plant stress responses. [PDF]
PLoS Genetics, 2013 Plant autophagy plays an important role in delaying senescence, nutrient recycling, and stress responses. Functional analysis of plant autophagy has almost exclusively focused on the proteins required for the core process of autophagosome assembly, but ...
Jie Zhou +6 more
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