Results 1 to 10 of about 4,878 (179)

Broad and Complex Roles of NBR1-Mediated Selective Autophagy in Plant Stress Responses [PDF]

Cells, 2020
Selective autophagy is a highly regulated degradation pathway for the removal of specific damaged or unwanted cellular components and organelles such as protein aggregates.
Zhixiang Chen, Yan Zhang
exaly   +6 more sources

NBR1-Mediated Selective Autophagy in Plant Development and Stress Responses [PDF]

Plants
Autophagy is a conserved degradation pathway essential for cellular homeostasis in plants. Selective autophagy confers cargo specificity through receptors, among which NEIGHBOR OF BRCA1 GENE1 (NBR1) is one of the best-characterized.
Xinye Li, Yali Duan, Jiyang Zhou, Peifeng Yu   +3 more
doaj   +3 more sources

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy. [PDF]

Adv Sci (Weinh)
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Lin Y, Dai M, Dai E, Kang R, Klionsky DJ, Tang D, Sun Y, Lv N, Jiang J.   +8 more
europepmc   +2 more sources

USP30-Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease. [PDF]

Adv Sci (Weinh)
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Li J, Hua C, Li G, Zhai F, Ren J, Pan S, Feng Q, Wen J, Liu D, Liu Z, Duan J.   +10 more
europepmc   +2 more sources

Selective Autophagy Receptor CsNBR1 Confers Citrus Huanglongbing Resistance by Degrading 'Candidatus Liberibacter Asiaticus' Virulence Effectors. [PDF]

Mol Plant Pathol
Overexpression of CsNBR1 confers HLB resistance in citrus by degrading CLas effector proteins, including SDE5115, SDE1, SDE19 and SDE5, via the autophagy pathway. ABSTRACT The selective autophagy receptor NEIGHBOUR OF BRCA1 (NBR1) is a key regulator of plant immunity, but its role against bacterial pathogens remains poorly understood.
Shi Y, Cui X, Fang F, Yang Z, Mei Y, Ma S, Zhou C, Wang X.   +7 more
europepmc   +2 more sources

Circadian gene CLOCK-mediated LLPS of NBR1 and p62/SQSTM1 inhibits proliferation and migration of nasopharyngeal carcinoma [PDF]

Cell Death and Disease
Circadian Locomotor Output Cycles Kaput (CLOCK) is a core circadian gene encoding a transcription factor essential for maintaining physiological rhythms, and has more recently been implicated in cancer biology.
Nasot Rashed, Ya Zhu, Jing Quan, Zhengjiang Li, Pai Zeng, Hongde Li, Wenbin Liu, Xi Zeng, Xiangjian Luo   +8 more
doaj   +2 more sources

NBR1-Mediated Autophagic Degradation of YTHDF1 Curtails FDX1 Translation to Drive Concurrent Multikinase Inhibitor Resistance and Cuproptosis Tolerance [PDF]

Cancer Communications
Background: Cancer cells frequently acquire adaptive resistance to targeted therapies; however, strategies capable of concurrently overcoming treatment tolerance and reactivating cell death pathways are currently lacking.
Weikai Wang, Xin Jiang, Xiaona Chen, Kaiyu Liang, Miaoqin Chen, Kaizhong Lu, Qi Wei, Yuchen Wu, Liyuan Zhu, Yuan Chen, Tianlun Hou, Jingfeng Luo, Chentao Li, Xian Wang, Hongchuan Jin, Lifeng Feng   +15 more
doaj   +2 more sources

The BTB/POZ-MATH Protein ZmBPM1 Interacts With Autophagy-related Protein ZmATG6 and Modulates the NLR Protein Rp1-D21-Mediated Defense Response in Maize. [PDF]

Adv Sci (Weinh)
The maize BTB/POZ‐MATH (BPM) protein ZmBPM1 interacts with autophagy‐related protein ZmATG6 to relocate the NLR protein Rp1‐D21 from the nucleo‐cytoplasmic compartment into autophagosome‐like puncta, leading to autophagy‐mediated turnover and suppressing the hypersensitive response.
Tang CX, Liu TT, Ge QD, Liu XY, Wang W, Sun Y, Liu Y, Li F, Wang GF.   +8 more
europepmc   +2 more sources

Integrated in vitro and bioinformatic analysis of autophagy‑related gene expression modulated by Fe₂O₃/Au core–shell nanoparticles in breast cancer cells [PDF]

BMC Cancer
Background Nanomaterials (NMs) with tunable physicochemical and redox properties offer powerful tools for probing cellular regulatory pathways. Accumulating evidence suggests that nanoparticles (NPs) exposure can engage autophagy, a conserved lysosome ...
Milad Sheervalilou, Saman Sargazi, Sheida Shahraki, Roghayeh Sheervalilou   +3 more
doaj   +2 more sources

Heat shock protein A1L restricts influenza A virus by ubiquitination of NA [PDF]

Journal of Virology
Neuraminidase (NA) protein of influenza A virus (IAV), a tetrameric envelope glycoprotein critical for viral release and spread, has well-characterized enzymatic functions but poorly resolved host-pathogen interactions.
Yan Yan, Jianan Xu, Zhen Chen, Yuting Xu, Linlong Qin, Lingyan Zhao, Hongli Zhang, Xiaoxiao Feng, Chaoliang Yao, Yu Huang, Jiyong Zhou, Tingjuan Deng   +11 more
doaj   +2 more sources