Results 21 to 30 of about 4,212 (160)

NBR1 acts as an autophagy receptor for peroxisomes [PDF]

Journal of Cell Science, 2012
Selective macro-autophagy is an intracellular process by which large cytoplasmic materials are selectively sequestered and degraded in the lysosomes. Substrate selection is mediated by ubiquitination and recruitment of ubiquitin-binding autophagic receptors such as p62, NBR1, NDP52 and Optineurin.
Elizabeth, Deosaran, Kenneth B, Larsen, Rong, Hua, Graeme, Sargent, Yuqing, Wang, Sarah, Kim, Trond, Lamark, Miluska, Jauregui, Kelsey, Law, Jennifer, Lippincott-Schwartz, Andreas, Brech, Terje, Johansen, Peter K, Kim   +12 more
openaire   +2 more sources

Elevated Expression of MiR-17 in Microglia of Alzheimer’s Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation

Frontiers in Immunology, 2021
Autophagy is a proposed route of amyloid-β (Aβ) clearance by microglia that is halted in Alzheimer’s Disease (AD), though mechanisms underlying this dysfunction remain elusive.
Shady Estfanous, Shady Estfanous, Kylene P. Daily, Mostafa Eltobgy, Nicholas P. Deems, Midhun N. K. Anne, Kathrin Krause, Kathrin Krause, Asmaa Badr, Kaitlin Hamilton, Cierra Carafice, Ahmad Hegazi, Arwa Abu Khweek, Arwa Abu Khweek, Hesham Kelani, Shahid Nimjee, Hamdy Awad, Xiaoli Zhang, Estelle Cormet-Boyaka, Hesham Haffez, Hesham Haffez, Sameh Soror, Sameh Soror, Adel Mikhail, Gerard Nuovo, Ruth M. Barrientos, Mikhail A. Gavrilin, Amal O. Amer   +27 more
doaj   +1 more source

p62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs and ESC-derived neurons

Life Science Alliance, 2023
This work shows a robust and stable aggrephagy regulation in mouse ESCs and ESC-derived neurons in absence of p62 and NBR1 functions. Accumulation of protein aggregates is a hallmark of various neurodegenerative diseases. Selective autophagy mediates the
Riccardo Trapannone, Julia Romanov, Sascha Martens   +2 more
doaj   +1 more source

Plant NBR1 is a selective autophagy substrate and a functional hybrid of the mammalian autophagic adapters NBR1 and p62/SQSTM1 [PDF]

Autophagy, 2011
(Macro)autophagy encompasses both an unselective, bulk degradation of cytoplasmic contents as well as selective autophagy of damaged organelles, intracellular microbes, protein aggregates, cellular structures and specific soluble proteins. Selective autophagy is mediated by autophagic adapters, like p62/SQSTM1 and NBR1.
Steingrim, Svenning, Trond, Lamark, Kirsten, Krause, Terje, Johansen   +3 more
openaire   +2 more sources

NBR1-mediated antiviral xenophagy in plant immunity [PDF]

Autophagy, 2017
Macroautophagy/autophagy intersects with metazoan virus infections in highly complex and multifaceted ways. Autophagy mechanisms are part of antiviral immunity, but can be manipulated by several viruses to the benefit of infection. In plants, however, the roles of autophagy in virus infections have only recently started to emerge.
Anders, Hafrén, Daniel, Hofius
openaire   +2 more sources

Implications of Selective Autophagy Dysfunction for ALS Pathology

Cells, 2020
Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. Due to the biological complexity of the disease, its etiology remains unknown.
Emiliano Vicencio, Sebastián Beltrán, Luis Labrador, Patricio Manque, Melissa Nassif, Ute Woehlbier   +5 more
doaj   +1 more source

Tumor‐Associated Macrophage‐Derived Exosomal LINC01232 Induces the Immune Escape in Glioma by Decreasing Surface MHC‐I Expression

Advanced Science, 2023
Tumor‐associated macrophage (TAM) infiltration facilitates glioma malignancy, but the underlying mechanisms remain unclear. Herein, it is reported that TAMs secrete exosomal LINC01232 to induce tumor immune escape.
Junjun Li, Keshan Wang, Chao Yang, Kai Zhu, Cheng Jiang, Minjie Wang, Zijie Zhou, Nan Tang, Qiangping Wang, Siqi Wang, Pengwei Shu, Hongliang Yuan, Zhiyong Xiong, Jinsong Li, Tao Liang, Jin Rao, Xuan Wang, Xiaobing Jiang   +17 more
doaj   +1 more source

Stratification of diabetic kidney diseases via data-independent acquisition proteomics–based analysis of human kidney tissue specimens

Frontiers in Endocrinology, 2022
AimThe aims of this study were to analyze the proteomic differences in renal tissues from patients with diabetes mellitus (DM) and diabetic kidney disease (DKD) and to select sensitive biomarkers for early identification of DKD progression ...
Qinghua Huang, Qinghua Huang, Xianming Fei, Zhaoxian Zhong, Jieru Zhou, Jianguang Gong, Yuan Chen, Yiwen Li, Xiaohong Wu, Xiaohong Wu   +9 more
doaj   +1 more source

Autophagic receptors Nbr1 and p62 coregulate skeletal remodelling [PDF]

Autophagy, 2010
Skeletal remodeling is an ongoing process requiring the coordinated action of different cell types to maintain homeostatic control of bone synthesis and degradation. Mutations in p62/SQSTM1 are associated with sporadic and 5q35-linked Paget Disease of Bone (PDB), characterized by focal increased bone turnover.
Waters, Sarah, Marchbank, Katie, Solomon, Ellen, Whitehouse, Caroline A.   +3 more
openaire   +3 more sources

BAG3 regulates the specificity of the recognition of specific MAPT species by NBR1 and SQSTM1

Autophagy, 2023
Abstract Autophagy receptors are essential for the recognition and clearance of specific cargos by selective autophagy, which is essential for maintaining MAPT proteostasis. Previous studies have implicated different autophagy receptors in directing distinct species of MAPT to autophagy, but the underlying mechanisms have not been fully
Heng Lin, Sarah Sandkuhler, Colleen Dunlea, Darron H King, Gail V. W. Johnson   +4 more
openaire   +4 more sources