Nbr1 Is a Novel Inhibitor of Ligand-Mediated Receptor Tyrosine Kinase Degradation [PDF]
Molecular and Cellular Biology, 2010 endocytic trafficking and selective autophagy. However, the exact function of Nbr1 in these contexts has not been studied in detail. Here we investigated the role of Nbr1 in the trafficking of receptor tyrosine kinases (RTKs).
Giulio Auciello +13 more
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E3 ubiquitin ligase CHIP and NBR1-mediated selective autophagy protect additively against proteotoxicity in plant stress responses. [PDF]
PLoS Genetics, 2014 Plant stress responses require both protective measures that reduce or restore stress-inflicted damage to cellular structures and mechanisms that efficiently remove damaged and toxic macromolecules, such as misfolded and damaged proteins.
Jie Zhou +6 more
doaj +2 more sources
p62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs and ESC-derived neurons
Life Science Alliance, 2023 This work shows a robust and stable aggrephagy regulation in mouse ESCs and ESC-derived neurons in absence of p62 and NBR1 functions. Accumulation of protein aggregates is a hallmark of various neurodegenerative diseases. Selective autophagy mediates the
Riccardo Trapannone +2 more
doaj +5 more sources
BAG3 regulates the specificity of the recognition of specific MAPT species by NBR1 and SQSTM1
Autophagy, 2023 Macroautophagy/autophagy receptors are essential for the recognition and clearance of specific cargos by selective autophagy, which is essential for maintaining MAPT proteostasis.
Joel Rodwell-Bullock (17302544) +5 more
core +5 more sources
Characterization of the Arabidopsis thaliana homologue of NBR1 [PDF]
, 2009 It is now well established that p62 and NBR1 are selectively degraded by autophagy and can act as cargo receptors or adaptors for the autophagic degradation of ubiquitinated substrates.
Svenning, Steingrim
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NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin
Chinese MedicineBackground Idiopathic pulmonary fibrosis is a persistent disease of the lung interstitium for which there is no efficacious pharmacological therapy. Protodioscin, a steroidal saponin, possesses diverse pharmacological properties; however, its function in
Qian Zeng +14 more
doaj +3 more sources
Mechanical signal modulates prostate cancer immune escape by USP8-mediated ubiquitination-dependent degradation of PD-L1 and MHC-1 [PDF]
Cell Death and DiseaseThe tumor environment of prostate cancer (PCa) tissues of high Gleason score has been proved to be more immune suppressive and has higher extracellular matrix (ECM) stiffness, but whether ECM mechanical stiffness is the cause of higher ability of ...
Zhi-Bin Ke +12 more
doaj +2 more sources
The LC3-interacting region of NBR1 is a protein interaction hub enabling optimal flux [PDF]
Journal of Cell BiologyAutophagy is a highly conserved pathway that maintains cell health by breaking down and recycling cellular components such as protein aggregates or damaged organelles. During autophagy, potentially toxic cargo is enveloped by a newly formed autophagosome
North, Brian Joseph
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Mapping of Nuclear Export Signals and domains mediating aggregation of NBR1 [PDF]
, 2017 Autophagy is a conserved catabolic pathway for the lysosomal degradation of cytoplasmic components. Autophagy can be both selective and unselective. Selective autophagy receptor proteins are involved in mediating the degradation of specific substrates ...
Næss, Morten Svendsen
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, 2023 International audienceNBR1, a plant selective autophagy receptor, associates with lipid droplets in germinating seeds and contributes to seed longevity Bouchez-Mahiout I., Deruyffelaere C, Salis V, Rajou L, Collet B, Masclaux-Daubresse C, Marmagne A and ...
Masclaux‐daubresse, Céline +7 more
core +4 more sources