Whole organism and tissue-specific analysis of pexophagy in Drosophila [PDF]
Open BiologyPeroxisomes are essential organelles involved in critical metabolic processes in animals such as fatty acid oxidation, ether phospholipid production and reactive oxygen species detoxification.
Marco Marcello +2 more
exaly +5 more sources
Pexophagy and Oxidative Stress: Focus on Peroxisomal Proteins and Reactive Oxygen Species (ROS) Signaling Pathways [PDF]
AntioxidantsPeroxisomes generate reactive oxygen species (ROS) and also play a role in protecting cells from the damaging effects of such radicals. Dysfunctional peroxisomes are recognized by receptors and degraded by a selective type of macroautophagy called ...
Hyunsoo Kim, Gyuho Jang, Raekil Park
exaly +5 more sources
Mechanisms and Functions of Pexophagy in Mammalian Cells
Cells, 2021 Peroxisomes play essential roles in diverse cellular metabolism functions, and their dynamic homeostasis is maintained through the coordination of peroxisome biogenesis and turnover.
exaly +4 more sources
Inhibition of BRD4 Promotes Pexophagy by Increasing ROS and ATM Activation
Cells, 2022 Although autophagy regulates the quality and quantity of cellular compartments, the regulatory mechanisms underlying peroxisomal autophagy (pexophagy) remain largely unknown.
Na Yeon Park, Ji-Eun Bae, Doo Sin Jo
exaly +4 more sources
Retromer Regulates Macro‐ and Micro‐Autophagy via Distinct Vacuolar Proteases in the Rice Blast Fungus [PDF]
Advanced ScienceThe vacuole degrades and recycles endocytic and autophagic cargos, while the retromer complex sorts cargos from the endosomes to the trans‐Golgi network or the plasma membrane, thus preventing unnecessary vacuolar degradation.
Dingyang Zhang +13 more
doaj +3 more sources
Peroxisome Proliferator Activator α Agonist Clofibrate Induces Pexophagy in Coconut Oil-Based High-Fat Diet-Fed Rats [PDF]
BiologyPeroxisomes are crucial for fatty acid β-oxidation in steatosis, but the role of pexophagy—the selective autophagy of peroxisomes—remains unclear. This study investigated the effects of the peroxisome proliferator-activated receptor-α (PPARα) agonist ...
Kanami Ohshima +12 more
doaj +3 more sources
Cyclo-C stabilizes PEX13 to inhibit porcine epidemic diarrhea virus replication by blocking pexophagy-mediated disruption of antiviral innate immunity [PDF]
Journal of VirologyThe persistent threat of porcine epidemic diarrhea virus (PEDV) to the global swine industry is compounded by high neonatal piglet mortality and the absence of effective antiviral therapies.
Jinxiu Lou +8 more
doaj +2 more sources
From homeostasis to pathology, organelle-specific autophagy in skeletal muscle: a PRISMA-ScR scoping review [PDF]
Frontiers in PhysiologyBackgroundAs the largest metabolic organ in the human body, skeletal muscle relies on the structural and functional integrity of its organelles for cellular viability and responsiveness.
Chunxiao Wang +5 more
doaj +2 more sources
SIRT5-mediated desuccinylation of the porcine deltacoronavirus M protein drives pexophagy to enhance viral proliferation. [PDF]
PLoS PathogensPorcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus capable of infecting various animal species, including humans. In this study, we explored the roles of sirtuins (SIRTs), a conserved family of protein deacylases and mono ...
Zhuang Li +7 more
doaj +2 more sources
PEDV NSP8 inhibits IFN-III production induced by MAVS through downregulation of PEX13 [PDF]
mBioPorcine epidemic diarrhea virus (PEDV), an enteropathogenic coronavirus that causes severe intestinal disease in piglets, employs sophisticated strategies to subvert host antiviral immunity.
Jinxiu Lou +5 more
doaj +2 more sources