AAA+ ATPase chaperone p97/VCPFAF2 governs basal pexophagy [PDF]
Nature CommunicationsPeroxisomes are organelles that are central to lipid metabolism and chemical detoxification. Despite advances in our understanding of peroxisome biogenesis, the mechanisms maintaining peroxisomal membrane proteins remain to be fully elucidated.
Koji Yamano +2 more
exaly +5 more sources
Upregulated pexophagy limits the capacity of selective autophagy [PDF]
Nature CommunicationsSelective autophagy is an essential process to maintain cellular homeostasis through the constant recycling of damaged or superfluous components. Over a dozen selective autophagy pathways mediate the degradation of diverse cellular substrates, but ...
Kyla Germain, Raphaella So, Joel C Watts
exaly +5 more sources
Whole organism and tissue-specific analysis of pexophagy in Drosophila [PDF]
Open BiologyPeroxisomes are essential organelles involved in critical metabolic processes in animals such as fatty acid oxidation, ether phospholipid production and reactive oxygen species detoxification.
Francesco G. Barone +4 more
doaj +3 more sources
Peroxisome Proliferator Activator α Agonist Clofibrate Induces Pexophagy in Coconut Oil-Based High-Fat Diet-Fed Rats [PDF]
BiologyPeroxisomes are crucial for fatty acid β-oxidation in steatosis, but the role of pexophagy—the selective autophagy of peroxisomes—remains unclear. This study investigated the effects of the peroxisome proliferator-activated receptor-α (PPARα) agonist ...
Kanami Ohshima +12 more
doaj +4 more sources
Mechanisms and Functions of Pexophagy in Mammalian Cells [PDF]
Cells, 2021 Peroxisomes play essential roles in diverse cellular metabolism functions, and their dynamic homeostasis is maintained through the coordination of peroxisome biogenesis and turnover.
Wei Wang
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Pexophagy and Oxidative Stress: Focus on Peroxisomal Proteins and Reactive Oxygen Species (ROS) Signaling Pathways [PDF]
AntioxidantsPeroxisomes generate reactive oxygen species (ROS) and also play a role in protecting cells from the damaging effects of such radicals. Dysfunctional peroxisomes are recognized by receptors and degraded by a selective type of macroautophagy called ...
Hyunsoo Kim, Gyuho Jang
exaly +4 more sources
Inhibition of VHL by VH298 Accelerates Pexophagy by Activation of HIF-1α in HeLa Cells [PDF]
MoleculesAutophagy is a pivotal biological process responsible for maintaining the homeostasis of intracellular organelles. Yet the molecular intricacies of peroxisomal autophagy (pexophagy) remain largely elusive.
Yong Hwan Kim +9 more
doaj +4 more sources
Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy [PDF]
Life Science Alliance, 2022 A detailed look at the properties of a novel USP30 inhibitor applied to studies of mitophagy and pexophagy. The deubiquitylase USP30 is an actionable target considered for treatment of conditions associated with defects in the PINK1-PRKN pathway leading ...
Emma V Rusilowicz-Jones +6 more
doaj +2 more sources
Pexophagy suppresses ROS-induced damage in leaf cells under high-intensity light [PDF]
Nature Communications, 2022 Pexophagy plays a pivotal role in the selective removal of ROS-generating peroxisomes, which protects plants from oxidative damage during photosynthesis under high-intensity light.
Kazusato Oikawa +19 more
doaj +2 more sources
Energy Charge as an Indicator of Pexophagy in Pichia pastoris [PDF]
Frontiers in Microbiology, 2017 Pichia pastoris is a good model for pexophagy research owing to its diverse pexophagy modes (macropexophagy and micropexophagy) exhibited during carbon-source shift from methanol to other carbon sources. The critical condition that triggers activation of
Jianguo Zhang, Taiyu Liu
doaj +2 more sources