Results 21 to 30 of about 2,561 (146)

Competition between binding partners of yeast Pex3 affects peroxisome biology. [PDF]

FEBS J
Pex3 is a peroxisomal membrane protein (PMP) that specifically recruits several binding partners. In the yeast Hansenula polymorpha, Atg30 (pexophagy), Inp1 (inheritance) and Pex19 (receptor for new PMPs) associate with Pex3. Overexpression of any of these proteins affects peroxisomal processes because these proteins compete for binding to Pex3.
de Lange EMF, Chojnowski G, Bürgi J, Vlijm R, Wilmanns M, van der Klei IJ.   +5 more
europepmc   +2 more sources

BNIP3L/NIX regulates both mitophagy and pexophagy [PDF]

, 2022
Mitochondria and peroxisomes are closely related metabolic organelles, both in terms of origin and in terms of function. Mitochondria and peroxisomes can also be turned over by autophagy, in processes termed mitophagy and pexophagy, respectively. However,
Boya, Patricia, Patricia Boya, Ganley, Ian G, Martins Freire, Catarina, Ashley M Toye, Ganley, Ian G.; id_orcid, Pellegrin, Stephanie, Léa P Wilhelm, Juan Zapata‐Muñoz, Villarejo‐Zori, Beatriz, Zapata-Muñoz, Juan, Toye, Ashley M., Ganley, Ian G., Beatriz Villarejo‐Zori, Toye, Ashley M, Catarina Martins Freire, Zapata‐Muñoz, Juan, Ian G Ganley, Stephanie Pellegrin, Wilhelm, Lea P., Freire, Catarina Martins, Wilhelm, Léa P, Villarejo-Zori, Beatriz   +22 more
core   +1 more source

Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy

Life Science Alliance, 2022
A detailed look at the properties of a novel USP30 inhibitor applied to studies of mitophagy and pexophagy. The deubiquitylase USP30 is an actionable target considered for treatment of conditions associated with defects in the PINK1-PRKN pathway leading ...
Emma V Rusilowicz-Jones, Francesco G Barone, Fernanda Martins Lopes, Elezabeth Stephen, Heather Mortiboys, Sylvie Urbé, Michael J Clague   +6 more
doaj   +1 more source

Peroxin 14 tags peroxisomes and interacts with Nbr1 for pexophagy in the filamentous insect pathogenic fungus Beauveria bassiana

Autophagy Reports, 2023
Pexophagy is a main pathway for selective degradation of peroxisomes. However, the molecular mechanisms underlying pexophagy remain fragmented in the filamentous fungi.
Hai-Yan Lin, Jia-Hui Lei, Jin-Li Ding, Yue-Jin Peng, Hao Zhang, Ming-Guang Feng, Sheng-Hua Ying   +6 more
doaj   +1 more source

Regulation of Peroxisome Homeostasis by Post-Translational Modification in the Methylotrophic Yeast Komagataella phaffii

Frontiers in Cell and Developmental Biology, 2022
The methylotrophic yeast Komagataella phaffii (synoym Pichia pastoris) can grow on methanol with an associated proliferation of peroxisomes, which are subsequently degraded by pexophagy upon depletion of methanol.
Shin Ohsawa, Masahide Oku, Hiroya Yurimoto, Yasuyoshi Sakai   +3 more
doaj   +1 more source

Enhanced Levels of Peroxisome-Derived H₂O₂ Do Not Induce Pexophagy but Impair Autophagic Flux in HEK-293 and HeLa Cells

Antioxidants, 2023
Peroxisomes are functionally specialized organelles that harbor multiple hydrogen peroxide (H2O2)-producing and -degrading enzymes. Given that this oxidant functions as a major redox signaling agent, peroxisomes have the intrinsic ability to mediate and ...
Hongli Li, Celien Lismont, Cláudio F. Costa, Mohamed A. F. Hussein, Myriam Baes, Marc Fransen   +5 more
doaj   +1 more source

AeiA, an Atg8-interacting protein in Aspergillus oryzae, promotes peroxisome degradation by pexophagy

Autophagy Reports, 2023
There are two types of autophagy, non-selective (bulk) autophagy, in which substrates are randomly incorporated into autophagosomes, and selective autophagy, in which substrates are specifically targeted.
Takashi Kikuma, Joichiro Nishio
doaj   +1 more source

Endoplasmic Reticulum–Mitochondria Contacts Are Required for Pexophagy in

Contact, 2019
Peroxisomes play important roles in lipid metabolism. Surplus or damaged peroxisomes can be selectively targeted for autophagic degradation, a process termed pexophagy . Maintaining a proper level of pexophagy is critical for cellular homeostasis.
Xu Liu, Xin Wen, Daniel J. Klionsky
doaj   +1 more source

Autophagy Inhibitors Do Not Restore Peroxisomal Functions in Cells With the Most Common Peroxisome Biogenesis Defect

Frontiers in Cell and Developmental Biology, 2021
Peroxisome biogenesis disorders within the Zellweger spectrum (PBD-ZSDs) are most frequently associated with the c.2528G>A (p.G843D) mutation in the PEX1 gene (PEX1-G843D), which results in impaired import of peroxisomal matrix proteins and ...
Femke C. C. Klouwer, Femke C. C. Klouwer, Kim D. Falkenberg, Rob Ofman, Janet Koster, Démi van Gent, Sacha Ferdinandusse, Ronald J. A. Wanders, Hans R. Waterham   +8 more
doaj   +1 more source

PEX13 prevents pexophagy by regulating ubiquitinated PEX5 and peroxisomal ROS

, 2022
Peroxisomes are rapidly degraded during amino acid and oxygen deprivation by a type of selective autophagy called pexophagy. However, how damaged peroxisomes are detected and removed from the cell is poorly understood.
Peter, K. Kim (14289383), G. Angus McQuibban (730282), Victoria Riccio (14289377), Seong-Kyu Choe (256094), Doo Sin Jo (6626939), Weifang Liao (5432003), Sushil Bhandari (13833662), Dong-Hyung Cho (293237), Kelsey B. Law (4035716), Nicholas, D. Demers (14289374), Choy Kim (14289380)   +10 more
core   +1 more source