Results 21 to 30 of about 4,214 (236)

PEDV NSP8 inhibits IFN-III production induced by MAVS through downregulation of PEX13 [PDF]

mBio
Porcine epidemic diarrhea virus (PEDV), an enteropathogenic coronavirus that causes severe intestinal disease in piglets, employs sophisticated strategies to subvert host antiviral immunity.
Jinxiu Lou, Huixin Zhu, Zhen Yang, Ping Jiang, Gongguan Liu, Xianwei Wang   +5 more
doaj   +2 more sources

STED super-resolution microscopy unveils the dynamics of Atg30 on yeast Pex3-labeled peroxisomes [PDF]

iScience
Summary: Peroxisomes are dynamic organelles with important metabolic functions. Yeast Pex3 is a multifunctional membrane protein aiding in peroxisomal biogenesis, inheritance, and degradation (pexophagy), by interacting with process-specific factors ...
Eline M.F. de Lange, Frank N. Mol, Ida J. van der Klei, Rifka Vlijm   +3 more
doaj   +2 more sources

EHHADH deficiency regulates pexophagy and accelerates tubulointerstitial injury in diabetic kidney disease [PDF]

Cell Death Discovery
Peroxisomal l-bifunctional enzyme (EHHADH) plays a role in the classic peroxisomal fatty acid β-oxidation pathway; however, the relationship between EHHADH expression and diabetic kidney disease has not been well understood.
Shuyan Kan, Qing Hou, Jinsong Shi, Mingchao Zhang, Feng Xu, Zhihong Liu, Song Jiang   +6 more
doaj   +2 more sources

Editor's evaluation: The peroxisomal exportomer directly inhibits phosphoactivation of the pexophagy receptor Atg36 to suppress pexophagy in yeast [PDF]

eLife, 2021
Autophagy receptor (or adaptor) proteins facilitate lysosomal destruction of various organelles in response to cellular stress, including nutrient deprivation. To what extent membrane-resident autophagy receptors also respond to organelle-restricted cues to induce selective autophagy remains poorly understood.
Hitoshi Nakatogawa
  +6 more sources

Regulation of pexophagy by a novel TBK1-MARCHF7-PXMP4-NBR1 axis in PEX1-depleted HeLa cells. [PDF]

Autophagy
Kim YH, Kim JB, Bae JE, Park NY, Kim SH, Um JY, Lee DS, Lee KS, Kim PK, Jo DS, Cho DH.   +10 more
europepmc   +2 more sources

Competition between binding partners of yeast Pex3 affects peroxisome biology. [PDF]

FEBS J
Pex3 is a peroxisomal membrane protein (PMP) that specifically recruits several binding partners. In the yeast Hansenula polymorpha, Atg30 (pexophagy), Inp1 (inheritance) and Pex19 (receptor for new PMPs) associate with Pex3. Overexpression of any of these proteins affects peroxisomal processes because these proteins compete for binding to Pex3.
de Lange EMF, Chojnowski G, Bürgi J, Vlijm R, Wilmanns M, van der Klei IJ.   +5 more
europepmc   +2 more sources

How Shall I Eat Thee? [PDF]

, 2007
The import of matrix proteins into peroxisomes in yeast requires the action of the ubiquitin-conjugating enzyme Pex4p and a complex consisting of the ubiquitin E3 ligases Pex2p, Pex10p and Pex12p.
Cuervo, Ana Maria, Dunn, Jr., William A., Klei, Ida van der, Klionsky, Daniel J., Levine, Beth, Seglen, Per O.   +5 more
core   +9 more sources

Inhibition of BRD4 Promotes Pexophagy by Increasing ROS and ATM Activation

Cells, 2022
Although autophagy regulates the quality and quantity of cellular compartments, the regulatory mechanisms underlying peroxisomal autophagy (pexophagy) remain largely unknown.
Yong Hwan Kim, Doo Sin Jo, Na Yeon Park, Ji-Eun Bae, Joon Bum Kim, Ha Jung Lee, So Hyun Kim, Seong Hyun Kim, Sunwoo Lee, Mikyung Son, Kyuhee Park, Kwiwan Jeong, Eunbyul Yeom, Dong-Hyung Cho   +13 more
doaj   +1 more source

Pexophagy: A Model for Selective Autophagy [PDF]

International Journal of Molecular Sciences, 2020
The removal of damaged or superfluous organelles from the cytosol by selective autophagy is required to maintain organelle function, quality control and overall cellular homeostasis. Precisely how substrate selectivity is achieved, and how individual substrates are degraded during selective autophagy in response to both extracellular and intracellular ...
Germain, Kyla, Kim, Peter K.
openaire   +2 more sources

The role of snx41-based pexophagy in magnaporthe development. [PDF]

PLoS ONE, 2013
Pexophagy, the degradation of peroxisomes via selective autophagy, depends on Atg20/Snx42 function in Saccharomyces cerevisiae. Besides its role in selective autophagy, Atg20/Snx42 is also involved in an autophagy-independent endosomal retrieval ...
Yizhen Deng, Ziwei Qu, Naweed I Naqvi
doaj   +1 more source