Results 31 to 40 of about 2,719 (141)
Pexophagy: A Model for Selective Autophagy
, 2020 The removal of damaged or superfluous organelles from the cytosol by selective autophagy is required to maintain organelle function, quality control and overall cellular homeostasis.
Kyla Germain, Peter K. Kim
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Frontiers in Cell and Developmental Biology, 2021 Peroxisome biogenesis disorders within the Zellweger spectrum (PBD-ZSDs) are most frequently associated with the c.2528G>A (p.G843D) mutation in the PEX1 gene (PEX1-G843D), which results in impaired import of peroxisomal matrix proteins and ...
Femke C. C. Klouwer +8 more
doaj +1 more source
The Mechanism of Mammalian Pexophagy [PDF]
, 2016 The mechanism of mammalian pexophagy is poorly understood. Although ubiquitination is thought to be involved in the process, the upstream and downstream effectors of ubiquitination remain elusive.
Sargent, Graeme John
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PEX13 prevents pexophagy by regulating ubiquitinated PEX5 and peroxisomal ROS
, 2022 Peroxisomes are rapidly degraded during amino acid and oxygen deprivation by a type of selective autophagy called pexophagy. However, how damaged peroxisomes are detected and removed from the cell is poorly understood.
Peter, K. Kim (14289383) +10 more
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Enhancement of xylanase expression by Komagataella phaffii through pexophagy inhibition
Biotechnology & Biotechnological Equipment, 2019 Xylanase is widely used in agriculture and food industry. To increase heterologous xylanase expression by Komagataella phaffii under the condition of mixed carbon source feeding, the atg30 gene was knocked out from this yeast to inhibit pexophagy for ...
Taiyu Liu +3 more
doaj +1 more source
Autophagy as a Survival Strategy for Eukaryotic Microbes Living in the Phyllosphere
Frontiers in Plant Science, 2022 Autophagy is an intracellular degradation process that is highly conserved among eukaryotes at the molecular level. The process was originally revealed in the budding yeast, but the physiological role of autophagy in yeast cells had remained unknown as ...
Kosuke Shiraishi, Yasuyoshi Sakai
doaj +1 more source
, 2015 Protein ubiquitylation in mammals is known to trigger selective autophagy of peroxisomes through a process termed pexophagy. The physiological peroxisomal target for pexophagy-related ubiquitylation has been controversial, but two studies have now ...
Suresh Subramani, Subramani, Suresh
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Frontiers in Cell and Developmental Biology, 2022 One peculiarity of protists belonging to classes Kinetoplastea and Diplonemea within the phylum Euglenozoa is compartmentalisation of most glycolytic enzymes within peroxisomes that are hence called glycosomes.
Diego Andrade-Alviárez +6 more
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Pexophagy suppresses ROS-induced damage in leaf cells under high-intensity light
Nature Communications, 2022 Pexophagy plays a pivotal role in the selective removal of ROS-generating peroxisomes, which protects plants from oxidative damage during photosynthesis under high-intensity light.
Kazusato Oikawa +19 more
doaj +1 more source
eLife, 2022 Autophagy receptor (or adaptor) proteins facilitate lysosomal destruction of various organelles in response to cellular stress, including nutrient deprivation. To what extent membrane-resident autophagy receptors also respond to organelle-restricted cues
Houqing Yu +2 more
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