Results 41 to 50 of about 2,719 (141)

Pexophagy. The Selective Autophagy of Peroxisomes [PDF]

, 2005
Pichia pastoris and Hansenula polymorpha are methylotrophic yeasts capable of utilizing methanol, as a sole source of carbon and energy. Growth of these yeast species on methanol requires the synthesis of cytosolic and peroxisomal enzymes combined with ...
Kiel, Jan A.K.W., Dunn, Jr., William A.,, Sibirny, Andrei A.,, Klei, Ida J. van der, Sibirny, Andrei A., Jan A.K.W. Kiel, Stasyk, Oleh V.,, Yasuyoshi Sakai, Marten Veenhuis, Veenhuis, Marten, Oleh V. Stasyk, Stasyk, Oleh V., Ida J. van der Klei, Klei, Ida J. van der; id_orcid, Andrei A. Sibirny, Cregg, James M., Sakai, Yasuyoshi,, Cregg, James M.,, Klei, Ida J. van der,, Oku, Masahide, Masahide Oku, Dunn, Jr., Sakai, Yasuyoshi, Veenhuis, Marten,, James M. Cregg, Kiel, Jan A.K.W.,, Oku, Masahide,, William A. Dunn, Jr.   +27 more
core   +2 more sources

The Peroxisome-Autophagy Redox Connection: A Double-Edged Sword?

Frontiers in Cell and Developmental Biology, 2021
Peroxisomes harbor numerous enzymes that can produce or degrade hydrogen peroxide (H2O2). Depending on its local concentration and environment, this oxidant can function as a redox signaling molecule or cause stochastic oxidative damage. Currently, it is
Hongli Li, Celien Lismont, Iulia Revenco, Mohamed A. F. Hussein, Mohamed A. F. Hussein, Cláudio F. Costa, Marc Fransen   +6 more
doaj   +1 more source

Tankyrase‐2 regulates adipocyte differentiation through AMPK/mTOR signaling

The FEBS Journal, EarlyView.
Tankyrase 2 (TNKS2), a PARP family member, underpins adipocyte differentiation. TNKS2 controls LKB1 protein level, and consequently, the activity of the mTOR/AMPK system and adipocyte differentiation through a layered process. Pharmacological inhibition of TNKS2 leaves other PARPs and DNA repair active and therefore represents a novel target in ...
Boglarka Rauch, Gyula Ujlaki, Szilard Poliska, Nakayi Murahwa, Patrik Kovacs, Aladar Pettko‐Szandtner, Karen Uray, Peter Bai   +7 more
wiley   +1 more source

DcH3.3 and DcNAC1 Regulate the Expression of UGT73A93 Involved in the Changes in Flower Colour and Fungal Resistance in Carnation

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4863-4877, August 2026.
ABSTRACT Carnation (Dianthus caryophyllus) contains abundant flavonoid glycosides (FGs), which are important natural functional and colour components. However, there are few reports on the modification of UDP‐glycosyltransferases (UGTs) in relation to flavonoids in carnation.
Xuhong Zhou, Qirui Xiong, Yue Zhang, Xiumei Yang, Siyuan Zhang, Yanxia Tao, Xiaomi Yang   +6 more
wiley   +1 more source

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

Plant peroxisomes are degraded by starvation-induced and constitutive autophagy in tobacco BY-2 suspension cultured cells

Frontiers in Plant Science, 2014
Very recently, autophagy has been recognized as an important degradation pathway for quality control of peroxisomes in Arabidopsis plants. To further characterize the role of autophagy in plant peroxisome degradation, we generated stable transgenic ...
Olga V. Voitsekhovskaja, Olga V. Voitsekhovskaja, Andreas eSchiermeyer, Sigrun eReumann, Sigrun eReumann, Sigrun eReumann   +5 more
doaj   +1 more source

Oxidative Stress‐Related Programmed Cell Death in Male Infertility: Focussing on Ferroptosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 10, May 2026.
ABSTRACT Oxidative stress is a common occurrence in testicular cells of infertile men and is considered a significant cause of male reproductive dysfunction. The increase in reactive oxygen species (ROS) leads to impaired spermatogenesis by activating caspases and generating free radicals from mitochondria, resulting in DNA damage and cell death ...
Nafiseh Sanei‐Ataabadi, Fatemeh Aboutalebi, Kianoush Dormiani, Mohammad Hossein Nasr‐Esfahani   +3 more
wiley   +1 more source

Catalase inhibition induces pexophagy through ROS accumulation

, 2018
Peroxisomes are dynamic and multifunctional organelles involved in various cellular metabolic processes, and their numbers are tightly regulated by pexophagy, a selective degradation of peroxisomes through autophagy to maintain peroxisome homeostasis in ...
Jae-Young Lim, Maharjan, Yunash, Lee, Joon No, Raghbendra Kumar Dutta, Zhi-qiang Liu, Seong-Kyu Choe, Joon No Lee, Raekil Park, Liu, Zhi-qiang, Dutta, Raghbendra Kumar, Dong-Hyung Cho, So, Hong-Seob, Yunash Maharjan, Kim, Se-Jin, Cho, Dong-Hyung, Choe, Seong-Kyu, Lim, Jae-Young, Hong-Seob So, Se-Jin Kim, Park, Raekil   +19 more
core   +1 more source

Pyridoxal Reprograms Peroxisomal Hydrogen Peroxide Metabolism to Induce Lethal Oxidative Stress in Ovarian Cancer

iMetaMed, Volume 2, Issue 1, March 2026.
Pyridoxal (PL) exhibits the strongest anti‐tumor activity within the vitamin B6 family, demonstrating significant ovarian cancer cell‐killing efficacy in vivo, in vitro, and in patient‐derived organoid (PDO) models. The anti‐tumor mechanism involves PL inducing a shift in peroxisome dynamics towards fission, promoting peroxisome proliferation, and ...
Ruonan Li, Huiyan Wang, Dunke Zhang, Qiuying Gu, Jinlong Wang, Bin Liu, Huabin Gao, Jingya Duan, Yimin Liu, Xiaolan Huang, Youquan Bu, Tongchuan He, Hua Linghu   +12 more
wiley   +1 more source

Peroxisome and pexophagy in neurological diseases

Fundamental Research
Peroxisomes and pexophagy have gained increasing attention in their role within the central nervous system (CNS) in recent years. In this review, we comprehensively discussed the physiological and pathological mechanisms of peroxisomes and pexophagy in ...
Weilin Xu, Jun Yan, Anwen Shao, Cameron Lenahan, Liansheng Gao, Haijian Wu, Jingwei Zheng, Jianmin Zhang, John H. Zhang   +8 more
doaj   +1 more source