Results 41 to 50 of about 2,561 (146)

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

Pexophagy. The Selective Autophagy of Peroxisomes [PDF]

, 2005
Pichia pastoris and Hansenula polymorpha are methylotrophic yeasts capable of utilizing methanol, as a sole source of carbon and energy. Growth of these yeast species on methanol requires the synthesis of cytosolic and peroxisomal enzymes combined with ...
Kiel, Jan A.K.W., Dunn, Jr., William A.,, Sibirny, Andrei A.,, Klei, Ida J. van der, Sibirny, Andrei A., Jan A.K.W. Kiel, Stasyk, Oleh V.,, Yasuyoshi Sakai, Marten Veenhuis, Veenhuis, Marten, Oleh V. Stasyk, Stasyk, Oleh V., Ida J. van der Klei, Klei, Ida J. van der; id_orcid, Andrei A. Sibirny, Cregg, James M., Sakai, Yasuyoshi,, Cregg, James M.,, Klei, Ida J. van der,, Oku, Masahide, Masahide Oku, Dunn, Jr., Sakai, Yasuyoshi, Veenhuis, Marten,, James M. Cregg, Kiel, Jan A.K.W.,, Oku, Masahide,, William A. Dunn, Jr.   +27 more
core   +1 more source

Oxidative Stress‐Related Programmed Cell Death in Male Infertility: Focussing on Ferroptosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 10, May 2026.
ABSTRACT Oxidative stress is a common occurrence in testicular cells of infertile men and is considered a significant cause of male reproductive dysfunction. The increase in reactive oxygen species (ROS) leads to impaired spermatogenesis by activating caspases and generating free radicals from mitochondria, resulting in DNA damage and cell death ...
Nafiseh Sanei‐Ataabadi, Fatemeh Aboutalebi, Kianoush Dormiani, Mohammad Hossein Nasr‐Esfahani   +3 more
wiley   +1 more source

Pyridoxal Reprograms Peroxisomal Hydrogen Peroxide Metabolism to Induce Lethal Oxidative Stress in Ovarian Cancer

iMetaMed, Volume 2, Issue 1, March 2026.
Pyridoxal (PL) exhibits the strongest anti‐tumor activity within the vitamin B6 family, demonstrating significant ovarian cancer cell‐killing efficacy in vivo, in vitro, and in patient‐derived organoid (PDO) models. The anti‐tumor mechanism involves PL inducing a shift in peroxisome dynamics towards fission, promoting peroxisome proliferation, and ...
Ruonan Li, Huiyan Wang, Dunke Zhang, Qiuying Gu, Jinlong Wang, Bin Liu, Huabin Gao, Jingya Duan, Yimin Liu, Xiaolan Huang, Youquan Bu, Tongchuan He, Hua Linghu   +12 more
wiley   +1 more source

Regulation of autophagy‐mediated pathways by diet, physical activity, and sleep in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease (AD) is a progressive, age‐related, neurodegenerative disorder marked by cognitive decline, memory loss, and accumulation of amyloid beta (Aβ) plaques and tau tangles. A key feature of AD is impaired protein homeostasis, often driven by autophagy dysfunction.
Ajish Ariyath, Zoe Mputhia, Christopher Dougherty, Bushra Kaleelur Rahuman, W. M. A. D. Binosha Fernando, Belinda Brown, Samantha L. Gardener, Stephanie R. Rainey‐Smith, Ralph Martins, Prashant Bharadwaj   +9 more
wiley   +1 more source

Plant peroxisomes are degraded by starvation-induced and constitutive autophagy in tobacco BY-2 suspension cultured cells

Frontiers in Plant Science, 2014
Very recently, autophagy has been recognized as an important degradation pathway for quality control of peroxisomes in Arabidopsis plants. To further characterize the role of autophagy in plant peroxisome degradation, we generated stable transgenic ...
Olga V. Voitsekhovskaja, Olga V. Voitsekhovskaja, Andreas eSchiermeyer, Sigrun eReumann, Sigrun eReumann, Sigrun eReumann   +5 more
doaj   +1 more source

Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections

Advanced Science, Volume 13, Issue 3, 14 January 2026.
This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin, Yuxiao Zheng, Yu Zhong, Hongyan Wang   +3 more
wiley   +1 more source

Regulatory Mechanism of Peroxisome Number Reduction Caused by FgPex4 and FgPex22-like Deletion in Fusarium graminearum

Journal of Fungi, 2023
Peroxisomes are single-membrane-bound organelles that play critical roles in eukaryotic cellular functions. Peroxisome quantity is a key factor influencing the homeostasis and pathogenic processes of pathogenic fungi.
Chunjie Liu, Zhuoyu Bi, Hao Xu, Renjie Zhang, Jiayi Wang, Yuancun Liang, Li Zhang, Jinfeng Yu   +7 more
doaj   +1 more source

Peroxisome and pexophagy in neurological diseases

Fundamental Research
Peroxisomes and pexophagy have gained increasing attention in their role within the central nervous system (CNS) in recent years. In this review, we comprehensively discussed the physiological and pathological mechanisms of peroxisomes and pexophagy in ...
Weilin Xu, Jun Yan, Anwen Shao, Cameron Lenahan, Liansheng Gao, Haijian Wu, Jingwei Zheng, Jianmin Zhang, John H. Zhang   +8 more
doaj   +1 more source

Lipid Autophagy: An Idea for the Treatment of Diabetic Nephropathy With Ginseng and Its Active Compounds

eFood, Volume 6, Issue 6, December 2025.
In light of the steadily increasing incidence of diabetic nephropathy (DN), this review explores the potential of edible natural products to slow disease progression, addressing the limitations of conventional clinical drug therapies. Key findings show that ginsenosides, the active compounds in edible ginseng, regulate lipid autophagy, reducing ...
Rui Zhang, Xushan Lan, Chenguang Wu, Jingjing Wang, Chengqian Yin, Lifan Wang, Peng Liu, Ping Li   +7 more
wiley   +1 more source