At Long Last: Evidence for Pexophagy in Plants [PDF]
Molecular Plant, 2014 Peroxisomes are highly dynamic single-membrane-bound eukaryotic organelles displaying great variability in enzymatic content (Platta and Erdmann, 2007). Plant peroxisomes function in a plethora of crucial development and stress ameliorating processes.
Tamar Avin‐Wittenberg +1 more
openalex +4 more sources
The peroxisome: still a mysterious organelle. [PDF]
, 2016 More than half a century of research on peroxisomes has revealed unique features of this ubiquitous subcellular organelle, which have often been in disagreement with existing dogmas in cell biology.
Fahimi, HD, Schrader, M
core +1 more source
The pestivirus N terminal protease N(pro) redistributes to mitochondria and peroxisomes suggesting new sites for regulation of IRF3 by N(pro.) [PDF]
, 2014 The N-terminal protease of pestiviruses, N(pro) is a unique viral protein, both because it is a distinct autoprotease that cleaves itself from the following polyprotein chain, and also because it binds and inactivates IRF3, a central regulator of ...
C Achmüller +36 more
core +2 more sources
Assays to Monitor Pexophagy in Yeast [PDF]
, 2017 Pexophagy is a selective autophagy process that degrades damaged and/or superfluous peroxisomes in the yeast vacuole or in mammalian lysosomes. The molecular mechanisms of pexophagy are well studied in yeast. Peroxisomes can be rapidly induced by oleate in the budding yeast, Saccharomyces cerevisiae, and by oleate or methanol in the methylotrophic ...
W, Wang, S, Subramani
openaire +2 more sources
Microbial Cell Factories / Repressible promoters \u2013 A novel tool to generate conditional mutants in Pichia pastoris [PDF]
, 2013 Background: Repressible promoters are a useful tool for down-regulating the expression of genes, especially those that affect cell viability, in order to study cell physiology.
Delic, Marizela +2 more
core +2 more sources
Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson's disease [PDF]
, 2019 The discovery of rare familial monogenic forms of early-onset Parkinson's disease has led to the identification of a mitochondrial quality control process as a key player in this disease.
Miller, Silke, Muqit, Miratul M. K.
core +2 more sources
eLife, 2022 Autophagy receptor (or adaptor) proteins facilitate lysosomal destruction of various organelles in response to cellular stress, including nutrient deprivation. To what extent membrane-resident autophagy receptors also respond to organelle-restricted cues
Houqing Yu +2 more
doaj +1 more source
Global impacts of peroxisome and pexophagy dysfunction revealed through multi-omics analyses of lon2 and atg2 mutants. [PDF]
Plant JSUMMARY Peroxisomes house diverse metabolic pathways that are essential for plant and animal survival, including enzymes that produce or inactivate toxic byproducts. Despite the importance of peroxisomes and their collaborations with other organelles, the mechanisms that trigger or prevent peroxisome turnover and the cellular impacts of impaired ...
Muhammad D +5 more
europepmc +2 more sources
The Cytoplasm-to-Vacuole Targeting Pathway: A Historical Perspective [PDF]
, 2012 From today's perspective, it is obvious that macroautophagy (hereafter autophagy) is an important pathway that is connected to a range of developmental and physiological processes.
Midori Umekawa, Daniel J. Klionsky
core +2 more sources
The Peroxisome-Autophagy Redox Connection: A Double-Edged Sword?
Frontiers in Cell and Developmental Biology, 2021 Peroxisomes harbor numerous enzymes that can produce or degrade hydrogen peroxide (H2O2). Depending on its local concentration and environment, this oxidant can function as a redox signaling molecule or cause stochastic oxidative damage. Currently, it is
Hongli Li +6 more
doaj +1 more source