Results 61 to 70 of about 2,719 (141)
The Kaohsiung Journal of Medical Sciences, Volume 41, Issue 12, December 2025.ABSTRACT Our previous study revealed the role of glycerol phosphate O‐acyltransferase (GNPAT) in regulating chronic obstructive pulmonary disease (COPD). However, its further mechanisms remained unclear. In this study, COPD models were established by exposing mice to cigarette smoke particulates.
Xin‐Gui Cheng +5 more
wiley +1 more source
USP30: protector of peroxisomes and mitochondria
Molecular & Cellular Oncology, 2019 In our recent publication, we describe a mechanism by which peroxisomes are protected from degradation by autophagy under basal conditions. Taking a page from mitophagy, peroxisomes also recruit the mitochondria deubiquitinating enzyme USP30 to counter ...
Victoria Riccio +2 more
doaj +1 more source
MedComm, Volume 6, Issue 12, December 2025.Nutrient deprivation triggers USP30 nuclear translocation via an N‐terminal nuclear localization signal (NLS), mediated through suppression of mTORC1‐dependent phosphorylation at serine 104, a modification constraining nuclear entry. Nuclear USP30 deubiquitinates TCF/LEF1 at K379 and K382 residues, disrupting recruitment of CBP/P300 co‐activators to ...
Xiaolin Li +15 more
wiley +1 more source
Pexophagy-linked degradation of the peroxisomal membrane protein Pex3p involves the ubiquitin–proteasome system [PDF]
, 2013 Peroxisome autophagy, also known as pexophagy, describes the wholesale degradation of peroxisomes via the vacuole, when organelles become damaged or redundant.
Williams, Chris, +4 more
core +3 more sources
Біологічні студії, 2011 UDP-glucose:sterol glucosyltransferase (EC 2.4.1.173) catalyses the biosynthesis of ergosterol glucoside, a minor membrane lipid present in yeasts and plants.
O. G. Stasyk, O. V. Stasyk
doaj +1 more source
Generation of pexophagy-deficient mutants in M. oryzae
, 2013 (A) Schematic illustration of pexophagy occurring during conidial germination and appressorial development in M. oryzae. Vacuolar accumulation of GFP-SRL (peroxisome) was first seen in the two non-germinating cells (1 and 2) of the conidium at the early ...
Ziwei Qu (478821) +2 more
core +1 more source
The phosphoprotein Rppa09976 bridges peroxisomal and isolation membranes during pexophagy [PDF]
, 2010 Peroxisomes are important single membrane organelles which are required for certain metabolic pathways. In yeast, Pichia pastoris, peroxisomes are degraded by selective autophagy pathway termed pexophagy.
Lotfi, Pouya
core +1 more source
Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro +5 more
wiley +1 more source
Postępy Mikrobiologii, 2019 The machinery of antibiotic production by Penicillium chrysogenum PQ-96 is composed of co-located cytosolic and peroxisomal enzymes of the penicillin G biosynthesis pathway.
Kurzątkowski Wiesław +4 more
doaj +1 more source
Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery
PROTEOMICS, Volume 25, Issue 21-22, Page 102-150, November 2025.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam +12 more
wiley +1 more source