Results 61 to 70 of about 2,561 (146)
Pexophagy-linked degradation of the peroxisomal membrane protein Pex3p involves the ubiquitin–proteasome system [PDF]
, 2013 Peroxisome autophagy, also known as pexophagy, describes the wholesale degradation of peroxisomes via the vacuole, when organelles become damaged or redundant.
Williams, Chris, +4 more
core +1 more source
Біологічні студії, 2011 UDP-glucose:sterol glucosyltransferase (EC 2.4.1.173) catalyses the biosynthesis of ergosterol glucoside, a minor membrane lipid present in yeasts and plants.
O. G. Stasyk, O. V. Stasyk
doaj +1 more source
Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery
PROTEOMICS, Volume 25, Issue 21-22, Page 102-150, November 2025.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam +12 more
wiley +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, Volume 599, Issue 16, Page 2250-2271, August 2025.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Inhibition of autophagy as a novel treatment for neurofibromatosis type 1 tumors
Molecular Oncology, Volume 19, Issue 3, Page 825-851, March 2025.We used synthetic lethal screens to find new approaches to treat neurofibromatosis type 1 (NF1) tumors. Inhibition of autophagy was identified as a robust method to selectively kill NF1‐deficient cells with minimal effects on healthy cells. Following assessment of a range of autophagy inhibitors, we determined that chloroquine has strong potential for ...
Megan Stevens +9 more
wiley +1 more source
Postępy Mikrobiologii, 2019 The machinery of antibiotic production by Penicillium chrysogenum PQ-96 is composed of co-located cytosolic and peroxisomal enzymes of the penicillin G biosynthesis pathway.
Kurzątkowski Wiesław +4 more
doaj +1 more source
Autophagy Stimulus-Dependent Role of the Small GTPase Ras2 in Peroxisome Degradation
Biomolecules, 2020 The changing accessibility of nutrient resources induces the reprogramming of cellular metabolism in order to adapt the cell to the altered growth conditions. The nutrient-depending signaling depends on the kinases mTOR (mechanistic target of rapamycin),
Fahd Boutouja, Harald W. Platta
doaj +1 more source
Genes to Cells, Volume 30, Issue 2, March 2025.ABSTRACT We previously developed a genome engineering method (TAQing2.0) based on the direct delivery of DNA endonucleases into living cells, which induces genome rearrangements even in non‐sporulating nonconventional yeasts without introducing foreign DNA.
Arisa H. Oda +5 more
wiley +1 more source
Investigation of pexophagy and autophagy occurrence in Arabidopsis
, 2023 Peroxisomes are critical organelles, housing various essential processes conserved across multicellular organisms. Most notable reactions include fatty-acid -oxidation and the detoxification of reactive oxygen species generated as byproducts from diverse
Smith, Kathryn Ann
core
The Mechanism of Mammalian Pexophagy
, 2016 The mechanism of mammalian pexophagy is poorly understood. Although ubiquitination is thought to be involved in the process, the upstream and downstream effectors of ubiquitination remain elusive.
Sargent, Graeme John
core +1 more source