Results 81 to 90 of about 4,214 (236)
eFood, Volume 6, Issue 6, December 2025.In light of the steadily increasing incidence of diabetic nephropathy (DN), this review explores the potential of edible natural products to slow disease progression, addressing the limitations of conventional clinical drug therapies. Key findings show that ginsenosides, the active compounds in edible ginseng, regulate lipid autophagy, reducing ...
Rui Zhang +7 more
wiley +1 more source
Journal of Fungi, 2023 Peroxisomes are single-membrane-bound organelles that play critical roles in eukaryotic cellular functions. Peroxisome quantity is a key factor influencing the homeostasis and pathogenic processes of pathogenic fungi.
Chunjie Liu +7 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 41, Issue 12, December 2025.ABSTRACT Our previous study revealed the role of glycerol phosphate O‐acyltransferase (GNPAT) in regulating chronic obstructive pulmonary disease (COPD). However, its further mechanisms remained unclear. In this study, COPD models were established by exposing mice to cigarette smoke particulates.
Xin‐Gui Cheng +5 more
wiley +1 more source
EPAS1/HIF-2α is a driver of mammalian pexophagy [PDF]
Autophagy, 2015 Oxygen (O2) is an essential substrate in cellular metabolism and signaling and as such is linked to the survival and normal function of metazoans. Central to the molecular mechanisms underlying O2 homeostasis are hypoxia-inducible factors (HIFs), heterodimeric transcription factors composed of O2-regulated α subunits (HIF1A/HIF-1α or EPAS1/HIF-2α), and
Schönenberger Miriam J. +2 more
openaire +2 more sources
MedComm, Volume 6, Issue 12, December 2025.Nutrient deprivation triggers USP30 nuclear translocation via an N‐terminal nuclear localization signal (NLS), mediated through suppression of mTORC1‐dependent phosphorylation at serine 104, a modification constraining nuclear entry. Nuclear USP30 deubiquitinates TCF/LEF1 at K379 and K382 residues, disrupting recruitment of CBP/P300 co‐activators to ...
Xiaolin Li +15 more
wiley +1 more source
Quality Control Gone Wrong: Mitochondria, Lysosomal Storage Disorders and Neurodegeneration. [PDF]
, 2013 The eukaryotic cell possesses specialized pathways to turnover and degrade redundant proteins and organelles. Each pathway is unique and responsible for degradation of distinctive cytosolic material.
Duchen, MR, Osellame, LD
core +1 more source
Mammalian pexophagy at a glance
Journal of Cell ScienceABSTRACT Peroxisomes are highly plastic organelles that are involved in several metabolic processes, including fatty acid oxidation, ether lipid synthesis and redox homeostasis. Their abundance and activity are dynamically regulated in response to nutrient availability and cellular stress.
Justyna Bajdzienko, Anja Bremm
openaire +2 more sources
Peroxisome degradation in mammals: mechanisms of action, recent advances, and perspectives
Frontiers in Physiology, 2013 Peroxisomes are remarkably dynamic organelles that participate in a diverse array of cellular processes, including the metabolism of lipids and reactive oxygen species.
Marcus eNordgren +3 more
doaj +1 more source
iLIR : a web resource for prediction of Atg8-family interacting proteins [PDF]
, 2014 Macroautophagy was initially considered to be a nonselective process for bulk breakdown of cytosolic material. However, recent evidence points toward a selective mode of autophagy mediated by the so-called selective autophagy receptors (SARs).
Johansen, Terje +6 more
core +1 more source
Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro +5 more
wiley +1 more source