Results 81 to 90 of about 2,561 (146)
Hsc70/Stub1 promotes the removal of individual oxidatively stressed peroxisomes
Nature Communications, 2020 Pexophagy removes damaged peroxisomes, which are particularly prone to ROS formation. Here, the authors use light to induce peroxisome turnover by local ROS generation, showing STUB1 translocation is critical and might contribute to human disease.
Bo-Hua Chen +3 more
doaj +1 more source
Cells, 2012 Autophagy is a ubiquitous eukaryotic process that also occurs in trypanosomatid parasites, protist organisms belonging to the supergroup Excavata, distinct from the supergroup Opistokontha that includes mammals and fungi.
Paul A. M. Michels +2 more
doaj +1 more source
, 2020 The important physiologic role of peroxisomes is shown by the occurrence of peroxisomal biogenesis disorders (PBDs) in humans. This spectrum of autosomal recessive metabolic disorders is characterized by defective peroxisome assembly and impaired ...
Rebecca Brinkmeier +2 more
core +1 more source
, 2013 Aims: We examined that (a) how the endotoxic stress affects peroxisomal function and autophagic degradation of peroxisomes-pexophagy, (b) how a superimposed dysfunction of lysosomes and pexophagy modifies responses to lipopolysaccharide (LPS), and (c ...
Chander, Praveen N. +7 more
core +2 more sources
Mutation of the Arabidopsis LON2 peroxisomal protease enhances pexophagy
, 2014 Peroxisomes are critical organelles housing various, often oxidative, reactions. Pexophagy, the process by which peroxisomes are selectively targeted for destruction via autophagy, is characterized in yeast and mammals but had not been reported in plants.
Rinaldi, Mauro A. +5 more
core +1 more source
Enhancement of xylanase expression by Komagataella phaffii through pexophagy inhibition
, 2019 Xylanase is widely used in agriculture and food industry. To increase heterologous xylanase expression by Komagataella phaffii under the condition of mixed carbon source feeding, the atg30 gene was knocked out from this yeast to inhibit pexophagy for ...
Taiyu Liu (6758810) +3 more
core +1 more source
, 2020 Peroxisomes are metabolically active oxygen demanding organelles with a high abundance of oxidases making it vulnerable to low oxygen levels such as hypoxic conditions.
Maharjan, Yunash +8 more
core +1 more source
Peroxisome Quality Control Factors in Pexophagy and Peroxisome Biogenesis Disorders
, 2017 Peroxisome biogenesis disorders (PBDs) are metabolic disorders caused by the loss of peroxisomes. Most PBDs result from mutation in one of 3 genes that encode for the peroxisomal AAA ATPase complex (AAA-complex) that is required for cycling ubiquitinated-
Law, Kelsey Barton
core +1 more source
Genome-wide analysis of kinases and phosphatases reveal an essential MAP kinase involved in pexophagy in Saccharomyces cerevisiae [PDF]
, 2008 Vital for human survival, peroxisomes are single membrane- bound organelles ubiquitously present in cells. Their role in cellular metabolism is required for certain metabolic pathways; consequently, in yeast, their biogenesis is inducible in the presence
Jain, Shveta
core
Characterization of pexophagy-deficient mutants in M. oryzae.
, 2013 (A) GFP-SRL mis-localizes to the cytoplasm in the pex14Δ mutant. Scale bar equals 10 micron. (B) Pexophagy is normal (restored) in M. oryzae atg26Δ, PEX141-258, and snx41Δ (ScSNX42) strains (in GFP-SRL background).
Ziwei Qu (478821) +2 more
core +1 more source