Results 71 to 80 of about 2,719 (141)
Autophagy Stimulus-Dependent Role of the Small GTPase Ras2 in Peroxisome Degradation
Biomolecules, 2020 The changing accessibility of nutrient resources induces the reprogramming of cellular metabolism in order to adapt the cell to the altered growth conditions. The nutrient-depending signaling depends on the kinases mTOR (mechanistic target of rapamycin),
Fahd Boutouja, Harald W. Platta
doaj +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, Volume 599, Issue 16, Page 2250-2271, August 2025.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Investigation of pexophagy and autophagy occurrence in Arabidopsis
, 2023 Peroxisomes are critical organelles, housing various essential processes conserved across multicellular organisms. Most notable reactions include fatty-acid -oxidation and the detoxification of reactive oxygen species generated as byproducts from diverse
Smith, Kathryn Ann
core
Inhibition of autophagy as a novel treatment for neurofibromatosis type 1 tumors
Molecular Oncology, Volume 19, Issue 3, Page 825-851, March 2025.We used synthetic lethal screens to find new approaches to treat neurofibromatosis type 1 (NF1) tumors. Inhibition of autophagy was identified as a robust method to selectively kill NF1‐deficient cells with minimal effects on healthy cells. Following assessment of a range of autophagy inhibitors, we determined that chloroquine has strong potential for ...
Megan Stevens +9 more
wiley +1 more source
Genes to Cells, Volume 30, Issue 2, March 2025.ABSTRACT We previously developed a genome engineering method (TAQing2.0) based on the direct delivery of DNA endonucleases into living cells, which induces genome rearrangements even in non‐sporulating nonconventional yeasts without introducing foreign DNA.
Arisa H. Oda +5 more
wiley +1 more source
Selective Autophagy of Peroxisomes in Plants: From Housekeeping to Development and Stress Responses
Frontiers in Plant Science, 2019 Peroxisomes are dynamic organelles involved in multiple functions, including oxygen and nitrogen reactive species metabolism. In plants, these organelles have a close relationship with chloroplasts and mitochondria, characterized by intense metabolic ...
Adela Olmedilla, Luisa M. Sandalio
doaj +1 more source
PEX2 is the E3 ubiquitin ligase required for pexophagy during starvation [PDF]
, 2016 Peroxisomes are metabolic organelles necessary for anabolic and catabolic lipid reactions whose numbers are highly dynamic based on the metabolic need of the cells.
Ling Zhang +13 more
core +2 more sources
Cells, 2019 The yeast vacuole is a vital organelle, which is required for the degradation of aberrant intracellular or extracellular substrates and the recycling of the resulting nutrients as newly available building blocks for the cellular metabolism.
Fahd Boutouja +6 more
doaj +1 more source
Dynamics of Peroxisome Homeostasis and Its Role in Stress Response and Signaling in Plants
Frontiers in Plant Science, 2019 Peroxisomes play vital roles in plant growth, development, and environmental stress response. During plant development and in response to environmental stresses, the number and morphology of peroxisomes are dynamically regulated to maintain peroxisome ...
Tong Su +3 more
doaj +1 more source
A Model of Autophagy Size Selectivity by Receptor Clustering on Peroxisomes
Frontiers in Physics, 2017 Selective autophagy must not only select the correct type of organelle, but also must discriminate between individual organelles of the same kind so that some but not all of the organelles are removed.
Aidan I. Brown +2 more
doaj +1 more source