Results 71 to 80 of about 2,561 (146)
An update on autophagy disorders
Journal of Inherited Metabolic Disease, Volume 48, Issue 1, January 2025.Abstract Macroautophagy is a highly conserved cellular pathway for the degradation and recycling of defective cargo including proteins, organelles, and macromolecular complexes. As autophagy is particularly relevant for cellular homeostasis in post‐mitotic tissues, congenital disorders of autophagy, due to monogenic defects in key autophagy genes ...
Hormos Salimi Dafsari +6 more
wiley +1 more source
Selective Autophagy of Peroxisomes in Plants: From Housekeeping to Development and Stress Responses
Frontiers in Plant Science, 2019 Peroxisomes are dynamic organelles involved in multiple functions, including oxygen and nitrogen reactive species metabolism. In plants, these organelles have a close relationship with chloroplasts and mitochondria, characterized by intense metabolic ...
Adela Olmedilla, Luisa M. Sandalio
doaj +1 more source
Organellar quality control crosstalk in aging‐related disease: Innovation to pave the way
Aging Cell, Volume 24, Issue 1, January 2025.Organellar homeostasis and inter‐organelle crosstalk are vital for cell survival. Quality control systems (QCS) maintain this balance, and their dysfunction is linked to aging‐related diseases like neurodegeneration and cancer. Our review explores QCS interactions among organelles and discusses potential therapies, aiming to identify new therapeutic ...
Yu Li +4 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 31, Issue 1, January 2025.Novel Ubiquitin‐Specific Protease‐30 (USP30) inhibitors target a key deubiquitinating enzyme, USP30, promoting the ubiquitination and subsequent clearance of dysfunctional mitochondria through the mitophagy pathway. This process offers therapeutic benefits in neurodegenerative diseases by enhancing neuronal cell health.
Ankit Siwach +3 more
wiley +1 more source
Cells, 2019 The yeast vacuole is a vital organelle, which is required for the degradation of aberrant intracellular or extracellular substrates and the recycling of the resulting nutrients as newly available building blocks for the cellular metabolism.
Fahd Boutouja +6 more
doaj +1 more source
The phosphoprotein Rppa09976 bridges peroxisomal and isolation membranes during pexophagy [PDF]
, 2010 Peroxisomes are important single membrane organelles which are required for certain metabolic pathways. In yeast, Pichia pastoris, peroxisomes are degraded by selective autophagy pathway termed pexophagy.
Lotfi, Pouya
core
Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy
Cell Reports, 2017 Tankyrase 1 (TNKS) and tankyrase 2 (TNKS2) belong to the poly(ADP-ribose) polymerase family of proteins, which use nicotinamide adenine dinucleotide to modify substrate proteins with ADP-ribose modifications.
Xu Li +7 more
doaj +1 more source
Dynamics of Peroxisome Homeostasis and Its Role in Stress Response and Signaling in Plants
Frontiers in Plant Science, 2019 Peroxisomes play vital roles in plant growth, development, and environmental stress response. During plant development and in response to environmental stresses, the number and morphology of peroxisomes are dynamically regulated to maintain peroxisome ...
Tong Su +3 more
doaj +1 more source
Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage. [PDF]
, 2019 peer reviewedNoise overexposure causes oxidative stress, leading to auditory hair cell damage. Adaptive peroxisome proliferation involving pejvakin, a peroxisome-associated protein from the gasdermin family, has been shown to protect against this harmful
Avan, Paul +5 more
core +1 more source
A Model of Autophagy Size Selectivity by Receptor Clustering on Peroxisomes
Frontiers in Physics, 2017 Selective autophagy must not only select the correct type of organelle, but also must discriminate between individual organelles of the same kind so that some but not all of the organelles are removed.
Aidan I. Brown +2 more
doaj +1 more source