Results 91 to 100 of about 4,214 (236)
Plant Peroxisomes: Biogenesis and Function [PDF]
, 2012 Peroxisomes are eukaryotic organelles that are highly dynamic both in morphology and metabolism. Plant peroxisomes are involved in numerous processes, including primary and secondary metabolism, development, and responses to abiotic and biotic stresses ...
Baker, Alison +6 more
core +2 more sources
Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery
PROTEOMICS, Volume 25, Issue 21-22, Page 102-150, November 2025.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam +12 more
wiley +1 more source
A family of membrane-shaping proteins at ER subdomains regulates pre-peroxisomal vesicle biogenesis [PDF]
, 2016 Saccharomyces cerevisiae contains three conserved reticulon and reticulon-like proteins that help maintain ER structure by stabilizing high membrane curvature in ER tubules and the edges of ER sheets.
Agrawal +54 more
core +2 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, Volume 599, Issue 16, Page 2250-2271, August 2025.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
USP30: protector of peroxisomes and mitochondria
Molecular & Cellular Oncology, 2019 In our recent publication, we describe a mechanism by which peroxisomes are protected from degradation by autophagy under basal conditions. Taking a page from mitophagy, peroxisomes also recruit the mitochondria deubiquitinating enzyme USP30 to counter ...
Victoria Riccio +2 more
doaj +1 more source
Біологічні студії, 2011 UDP-glucose:sterol glucosyltransferase (EC 2.4.1.173) catalyses the biosynthesis of ergosterol glucoside, a minor membrane lipid present in yeasts and plants.
O. G. Stasyk, O. V. Stasyk
doaj +1 more source
Inhibition of autophagy as a novel treatment for neurofibromatosis type 1 tumors
Molecular Oncology, Volume 19, Issue 3, Page 825-851, March 2025.We used synthetic lethal screens to find new approaches to treat neurofibromatosis type 1 (NF1) tumors. Inhibition of autophagy was identified as a robust method to selectively kill NF1‐deficient cells with minimal effects on healthy cells. Following assessment of a range of autophagy inhibitors, we determined that chloroquine has strong potential for ...
Megan Stevens +9 more
wiley +1 more source
Genes to Cells, Volume 30, Issue 2, March 2025.ABSTRACT We previously developed a genome engineering method (TAQing2.0) based on the direct delivery of DNA endonucleases into living cells, which induces genome rearrangements even in non‐sporulating nonconventional yeasts without introducing foreign DNA.
Arisa H. Oda +5 more
wiley +1 more source
An update on autophagy disorders
Journal of Inherited Metabolic Disease, Volume 48, Issue 1, January 2025.Abstract Macroautophagy is a highly conserved cellular pathway for the degradation and recycling of defective cargo including proteins, organelles, and macromolecular complexes. As autophagy is particularly relevant for cellular homeostasis in post‐mitotic tissues, congenital disorders of autophagy, due to monogenic defects in key autophagy genes ...
Hormos Salimi Dafsari +6 more
wiley +1 more source
Pexophagy in yeast and mammals: an update on mysteries [PDF]
Histochemistry and Cell Biology, 2018 ISSN:0948 ...
Tanja Eberhart, Werner J. Kovacs
openaire +3 more sources