Cells, 2019 The yeast vacuole is a vital organelle, which is required for the degradation of aberrant intracellular or extracellular substrates and the recycling of the resulting nutrients as newly available building blocks for the cellular metabolism.
Fahd Boutouja +6 more
doaj +1 more source
Genetic aberrations in macroautophagy genes leading to diseases [PDF]
, 2018 The catabolic process of macroautophagy, through the rapid degradation of unwanted cellular components, is involved in a multitude of cellular and organismal functions that are essential to maintain homeostasis.
Klionsky, Daniel J +2 more
core +1 more source
Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy
Cell Reports, 2017 Tankyrase 1 (TNKS) and tankyrase 2 (TNKS2) belong to the poly(ADP-ribose) polymerase family of proteins, which use nicotinamide adenine dinucleotide to modify substrate proteins with ADP-ribose modifications.
Xu Li +7 more
doaj +1 more source
miR-142 induces accumulation of reactive oxygen species (ROS) by inhibiting pexophagy in aged bone marrow mesenchymal stem cells [PDF]
, 2020 Kei Houri +7 more
openalex +1 more source
Physiological response of Pichia pastoris GS115 to methanol-induced high level production of the Hepatitis B surface antigen: Catabolic adaptation, stress responses, and autophagic processes [PDF]
, 2012 Background: Pichia pastoris is an established eukaryotic host for the production of recombinant proteins. Most often, protein production is under the control of the strong methanol-inducible aox1 promoter.
Adnan, Ahmad +6 more
core +4 more sources
Dynamics of Peroxisome Homeostasis and Its Role in Stress Response and Signaling in Plants
Frontiers in Plant Science, 2019 Peroxisomes play vital roles in plant growth, development, and environmental stress response. During plant development and in response to environmental stresses, the number and morphology of peroxisomes are dynamically regulated to maintain peroxisome ...
Tong Su +3 more
doaj +1 more source
Giant peroxisomes in a moss (Physcomitrella patens) peroxisomal biogenesis factor 11 mutant [PDF]
, 2016 Peroxisomal biogenesis factor 11 (PEX11) proteins are found in yeasts, mammals and plants, and play a role in peroxisome morphology and regulation of peroxisome division.
Abramoff +64 more
core +1 more source
A Model of Autophagy Size Selectivity by Receptor Clustering on Peroxisomes
Frontiers in Physics, 2017 Selective autophagy must not only select the correct type of organelle, but also must discriminate between individual organelles of the same kind so that some but not all of the organelles are removed.
Aidan I. Brown +2 more
doaj +1 more source
Hsc70/Stub1 promotes the removal of individual oxidatively stressed peroxisomes
Nature Communications, 2020 Pexophagy removes damaged peroxisomes, which are particularly prone to ROS formation. Here, the authors use light to induce peroxisome turnover by local ROS generation, showing STUB1 translocation is critical and might contribute to human disease.
Bo-Hua Chen +3 more
doaj +1 more source
The autophagosome:current understanding of formation and maturation [PDF]
, 2015 Autophagy is an important and highly conserved catabolic process with roles in development, homeostasis, and cellular stress responses. It describes various distinct pathways for the delivery of cytoplasmic materials (including misfolded protein ...
Lane, Jon D, Mannack, Lilith V J
core +2 more sources