Results 51 to 60 of about 2,561 (146)
Catalase inhibition induces pexophagy through ROS accumulation
, 2018 Peroxisomes are dynamic and multifunctional organelles involved in various cellular metabolic processes, and their numbers are tightly regulated by pexophagy, a selective degradation of peroxisomes through autophagy to maintain peroxisome homeostasis in ...
Jae-Young Lim +19 more
core +1 more source
PEX2 is the E3 ubiquitin ligase required for pexophagy during starvation [PDF]
, 2016 Peroxisomes are metabolic organelles necessary for anabolic and catabolic lipid reactions whose numbers are highly dynamic based on the metabolic need of the cells.
Ling Zhang +13 more
core +1 more source
Peroxisome degradation in mammals: mechanisms of action, recent advances, and perspectives
Frontiers in Physiology, 2013 Peroxisomes are remarkably dynamic organelles that participate in a diverse array of cellular processes, including the metabolism of lipids and reactive oxygen species.
Marcus eNordgren +3 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 41, Issue 12, December 2025.ABSTRACT Our previous study revealed the role of glycerol phosphate O‐acyltransferase (GNPAT) in regulating chronic obstructive pulmonary disease (COPD). However, its further mechanisms remained unclear. In this study, COPD models were established by exposing mice to cigarette smoke particulates.
Xin‐Gui Cheng +5 more
wiley +1 more source
MedComm, Volume 6, Issue 12, December 2025.Nutrient deprivation triggers USP30 nuclear translocation via an N‐terminal nuclear localization signal (NLS), mediated through suppression of mTORC1‐dependent phosphorylation at serine 104, a modification constraining nuclear entry. Nuclear USP30 deubiquitinates TCF/LEF1 at K379 and K382 residues, disrupting recruitment of CBP/P300 co‐activators to ...
Xiaolin Li +15 more
wiley +1 more source
Pexophagy and peroxisomal protein turnover in plants
, 2016 Peroxisomes are dynamic, vital organelles that sequester a variety of oxidative reactions and their toxic byproducts from the remainder of the cell.
Young, Pierce G., Bartel, Bonnie
core +1 more source
New aspects of USP30 biology in the regulation of pexophagy [PDF]
, 2019 Mitochondria and peroxisomes have a number of features in common: they each play interconnected roles in fatty acid and reactive oxygen species (ROS) metabolism and, once damaged, need to be removed by specialized autophagic mechanisms, termed mitophagy ...
Jardine, Jane +5 more
core +1 more source
USP30: protector of peroxisomes and mitochondria
Molecular & Cellular Oncology, 2019 In our recent publication, we describe a mechanism by which peroxisomes are protected from degradation by autophagy under basal conditions. Taking a page from mitophagy, peroxisomes also recruit the mitochondria deubiquitinating enzyme USP30 to counter ...
Victoria Riccio +2 more
doaj +1 more source
Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro +5 more
wiley +1 more source
Generation of pexophagy-deficient mutants in M. oryzae
, 2013 (A) Schematic illustration of pexophagy occurring during conidial germination and appressorial development in M. oryzae. Vacuolar accumulation of GFP-SRL (peroxisome) was first seen in the two non-germinating cells (1 and 2) of the conidium at the early ...
Ziwei Qu (478821) +2 more
core +1 more source