Results 51 to 60 of about 4,214 (236)

Autophagy Inhibitors Do Not Restore Peroxisomal Functions in Cells With the Most Common Peroxisome Biogenesis Defect

Frontiers in Cell and Developmental Biology, 2021
Peroxisome biogenesis disorders within the Zellweger spectrum (PBD-ZSDs) are most frequently associated with the c.2528G>A (p.G843D) mutation in the PEX1 gene (PEX1-G843D), which results in impaired import of peroxisomal matrix proteins and ...
Femke C. C. Klouwer, Femke C. C. Klouwer, Kim D. Falkenberg, Rob Ofman, Janet Koster, Démi van Gent, Sacha Ferdinandusse, Ronald J. A. Wanders, Hans R. Waterham   +8 more
doaj   +1 more source

Reevaluation of the role of Pex1 and dynamin-related proteins in peroxisome membrane biogenesis [PDF]

, 2015
A recent model for peroxisome biogenesis postulates that peroxisomes form de novo continuously in wild-type cells by heterotypic fusion of endoplasmic reticulum–derived vesicles containing distinct sets of peroxisomal membrane proteins.
Agne, Agrawal, Alison M. Motley, Aranovich, Arimura, Barton, Bascom, Bonekamp, Cepińska, Chen, David, Debelyy, Delille, Dimitrov, Elgersma, Ewald H. Hettema, Faber, Fakieh, Fang, Ghaemmaghami, Gietz, Goldstein, Gould, Gould, Gärtner, Haan, Halbach, Hensel, Hettema, Hettema, Hoepfner, Hoepfner, Huybrechts, James M. Nuttall, Jones, Karnik, Kiel, Kim, Kim, Knoblach, Knoops, Koek, Kragt, Kuravi, Lakhan Ekal, Lam, Lazarow, Liu, Liu, Managadze, Manivannan, Matsuzaki, Mattiazzi Ušaj, Menendez-Benito, Miyata, Miyata, Motley, Motley, Motley, Motley, Mukherji, Nagotu, Nishimura, Nunnari, Nuttall, Nuttall, Okumoto, Otera, Paul C. Galvin, Pinto, Platta, Platta, Platta, Platta, Pu, Rosenkranz, Rottensteiner, Sacksteder, Santos, Tabak, Tam, Titorenko, Titorenko, Toro, Uetz, van der Zand, van der Zand, van der Zand, van Roermund, Vizeacoumar, Williams, Williams, Yagita, Yan   +93 more
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Pexophagy in Fungal Pathogenesis [PDF]

The Plant Cell, 2009
Autophagy is a process of cellular self-eating in which individual protein molecules, regions of cytoplasm, or entire organelles are surrounded by an autophagic membrane and delivered to the lysosome (or yeast vacuole) for degradation.
openaire   +2 more sources

Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy [PDF]

Journal of Cell Biology, 2021
Mitochondria and peroxisomes are independent but functionally closely related organelles. A few proteins have been characterized as dual-organelle locating proteins with distinct or similar roles on mitochondria and peroxisomes. MARCH5 is a mitochondria-associated ubiquitin ligase best known for its regulatory role in mitochondria quality control ...
Jun Zheng, Xi Chen, Qiang Liu, Guisheng Zhong, Min Zhuang   +4 more
openaire   +2 more sources

Organelle Turnover:A USP30 Safety Catch Restrains the Trigger for Mitophagy and Pexophagy [PDF]

, 2018
It is crucial to remove dysfunctional mitochondria and peroxisomes to prevent cellular damage. Recent work suggests that under basal conditions USP30, a deubiquitinating enzyme, works to ensure that both of these organelles are only turned over at the ...
Ganley, Ian G.
core   +2 more sources

A Peroxisomal Lon Protease and Peroxisome Degradation by Autophagy Play Key Roles in Vitality of Hansenula polymorpha Cells [PDF]

, 2007
In eukaryote cells various mechanisms exist that are responsible for the removal of non-functional proteins. Here we show that in the yeast Hansenula polymorpha (H.
Bener Aksam, Eda, Jourdan, Stefanie, Kiel, Jan A.K.W., Klei, Ida J. van der, Koek, Anne, Veenhuis, Marten   +5 more
core   +2 more sources

A Hexose Transporter Homologue Controls Glucose Repression in the Methylotrophic Yeast Hansenula polymorpha [PDF]

, 2004
Peroxisome biogenesis and synthesis of peroxisomal enzymes in the methylotrophic yeast Hansenula polymorpha are under the strict control of glucose repression. We identified an H.
Cregg, James M., Komduur, Janet, Sibirny, Andrei A., Stasyk, Oleh V., Stasyk, Olena G., Veenhuis, Marten   +5 more
core   +1 more source

Enhancement of xylanase expression by Komagataella phaffii through pexophagy inhibition

Biotechnology & Biotechnological Equipment, 2019
Xylanase is widely used in agriculture and food industry. To increase heterologous xylanase expression by Komagataella phaffii under the condition of mixed carbon source feeding, the atg30 gene was knocked out from this yeast to inhibit pexophagy for ...
Taiyu Liu, Yixin Zhao, Jianguo Zhang, Jining Zhang   +3 more
doaj   +1 more source

Autophagy as a Survival Strategy for Eukaryotic Microbes Living in the Phyllosphere

Frontiers in Plant Science, 2022
Autophagy is an intracellular degradation process that is highly conserved among eukaryotes at the molecular level. The process was originally revealed in the budding yeast, but the physiological role of autophagy in yeast cells had remained unknown as ...
Kosuke Shiraishi, Yasuyoshi Sakai
doaj   +1 more source

Delineating transitions during the evolution of specialised peroxisomes: Glycosome formation in kinetoplastid and diplonemid protists

Frontiers in Cell and Developmental Biology, 2022
One peculiarity of protists belonging to classes Kinetoplastea and Diplonemea within the phylum Euglenozoa is compartmentalisation of most glycolytic enzymes within peroxisomes that are hence called glycosomes.
Diego Andrade-Alviárez, Alejandro D. Bonive-Boscan, Ana J. Cáceres, Wilfredo Quiñones, Melisa Gualdrón-López, Michael L. Ginger, Paul A. M. Michels   +6 more
doaj   +1 more source