AAA+ ATPase chaperone p97/VCPFAF2 governs basal pexophagy [PDF]
Nature CommunicationsPeroxisomes are organelles that are central to lipid metabolism and chemical detoxification. Despite advances in our understanding of peroxisome biogenesis, the mechanisms maintaining peroxisomal membrane proteins remain to be fully elucidated.
Fumika Koyano +6 more
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m6A-Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress. [PDF]
Adv Sci (Weinh)Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.
Zhang XX +18 more
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The role of snx41-based pexophagy in magnaporthe development. [PDF]
PLoS ONE, 2013 Pexophagy, the degradation of peroxisomes via selective autophagy, depends on Atg20/Snx42 function in Saccharomyces cerevisiae. Besides its role in selective autophagy, Atg20/Snx42 is also involved in an autophagy-independent endosomal retrieval ...
Yizhen Deng, Ziwei Qu, Naweed I Naqvi
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Segregation of pathways leading to pexophagy [PDF]
Life Science Alliance, 2023 Pexophagy occurs via distinct NIX- and USP30/NBR1-dependent pathways. Peroxisomes are organelles with key roles in metabolism including long-chain fatty acid production.
Francesco G Barone +2 more
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Energy Charge as an Indicator of Pexophagy in Pichia pastoris [PDF]
Frontiers in Microbiology, 2017 Pichia pastoris is a good model for pexophagy research owing to its diverse pexophagy modes (macropexophagy and micropexophagy) exhibited during carbon-source shift from methanol to other carbon sources. The critical condition that triggers activation of
Jianguo Zhang, Taiyu Liu
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Sensing and signaling for peroxisome autophagic degradation (pexophagy) in yeasts [PDF]
The Ukrainian Biochemical Journal, 2013 Yeast cells, similarly to cells of other eukaryotic organisms, possess intracellular organelles, including that of peroxisomes also known as microbodies.
A. A. Sibirny
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Pexophagy: The Selective Degradation of Peroxisomes [PDF]
International Journal of Cell Biology, 2012 Peroxisomes are single-membrane-bounded organelles present in the majority of eukaryotic cells. Despite the existence of great diversity among different species, cell types, and under different environmental conditions, peroxisomes contain enzymes ...
Andreas Till +3 more
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Upregulated pexophagy limits the capacity of selective autophagy
Nature CommunicationsSelective autophagy is an essential process to maintain cellular homeostasis through the constant recycling of damaged or superfluous components. Over a dozen selective autophagy pathways mediate the degradation of diverse cellular substrates, but ...
Robert Bandsma +2 more
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Inhibition of VHL by VH298 Accelerates Pexophagy by Activation of HIF-1α in HeLa Cells
MoleculesAutophagy is a pivotal biological process responsible for maintaining the homeostasis of intracellular organelles. Yet the molecular intricacies of peroxisomal autophagy (pexophagy) remain largely elusive.
Yong Hwan Kim +9 more
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Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy
Cell Reports, 2017 Tankyrase 1 (TNKS) and tankyrase 2 (TNKS2) belong to the poly(ADP-ribose) polymerase family of proteins, which use nicotinamide adenine dinucleotide to modify substrate proteins with ADP-ribose modifications.
Junjie Chen, Xu Li, Han Han
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