Results 11 to 20 of about 2,561 (146)
AAA+ ATPase chaperone p97/VCPFAF2 governs basal pexophagy [PDF]
Nature CommunicationsPeroxisomes are organelles that are central to lipid metabolism and chemical detoxification. Despite advances in our understanding of peroxisome biogenesis, the mechanisms maintaining peroxisomal membrane proteins remain to be fully elucidated.
Fumika Koyano +6 more
doaj +3 more sources
EHHADH deficiency regulates pexophagy and accelerates tubulointerstitial injury in diabetic kidney disease [PDF]
Cell Death DiscoveryPeroxisomal l-bifunctional enzyme (EHHADH) plays a role in the classic peroxisomal fatty acid β-oxidation pathway; however, the relationship between EHHADH expression and diabetic kidney disease has not been well understood.
Shuyan Kan +6 more
doaj +3 more sources
The role of snx41-based pexophagy in magnaporthe development. [PDF]
PLoS ONE, 2013 Pexophagy, the degradation of peroxisomes via selective autophagy, depends on Atg20/Snx42 function in Saccharomyces cerevisiae. Besides its role in selective autophagy, Atg20/Snx42 is also involved in an autophagy-independent endosomal retrieval ...
Yizhen Deng, Ziwei Qu, Naweed I Naqvi
doaj +2 more sources
Segregation of pathways leading to pexophagy [PDF]
Life Science Alliance, 2023 Pexophagy occurs via distinct NIX- and USP30/NBR1-dependent pathways. Peroxisomes are organelles with key roles in metabolism including long-chain fatty acid production.
Francesco G Barone +2 more
doaj +2 more sources
Sensing and signaling for peroxisome autophagic degradation (pexophagy) in yeasts [PDF]
The Ukrainian Biochemical Journal, 2013 Yeast cells, similarly to cells of other eukaryotic organisms, possess intracellular organelles, including that of peroxisomes also known as microbodies.
A. A. Sibirny
doaj +2 more sources
Pexophagy: The Selective Degradation of Peroxisomes [PDF]
International Journal of Cell Biology, 2012 Peroxisomes are single-membrane-bounded organelles present in the majority of eukaryotic cells. Despite the existence of great diversity among different species, cell types, and under different environmental conditions, peroxisomes contain enzymes ...
Andreas Till +3 more
doaj +2 more sources
STED super-resolution microscopy unveils the dynamics of Atg30 on yeast Pex3-labeled peroxisomes [PDF]
iScienceSummary: Peroxisomes are dynamic organelles with important metabolic functions. Yeast Pex3 is a multifunctional membrane protein aiding in peroxisomal biogenesis, inheritance, and degradation (pexophagy), by interacting with process-specific factors ...
Eline M.F. de Lange +3 more
doaj +2 more sources
Upregulated pexophagy limits the capacity of selective autophagy
Nature CommunicationsSelective autophagy is an essential process to maintain cellular homeostasis through the constant recycling of damaged or superfluous components. Over a dozen selective autophagy pathways mediate the degradation of diverse cellular substrates, but ...
Raphaella W L So +2 more
exaly +2 more sources
Inhibition of VHL by VH298 Accelerates Pexophagy by Activation of HIF-1α in HeLa Cells
MoleculesAutophagy is a pivotal biological process responsible for maintaining the homeostasis of intracellular organelles. Yet the molecular intricacies of peroxisomal autophagy (pexophagy) remain largely elusive.
Yong Hwan Kim +9 more
doaj +2 more sources
Re-exploration of all ATG genes [PDF]
Autophagy ReportsMost autophagy-related (ATG) genes have been identified and characterized through studies using the budding yeast Saccharomyces cerevisiae. However, there are no studies that comprehensively compare the contribution of each ATG gene to non-selective bulk
Kentaro Furukawa +2 more
doaj +2 more sources