Results 11 to 20 of about 4,214 (236)
Retromer Regulates Macro‐ and Micro‐Autophagy via Distinct Vacuolar Proteases in the Rice Blast Fungus [PDF]
Advanced ScienceThe vacuole degrades and recycles endocytic and autophagic cargos, while the retromer complex sorts cargos from the endosomes to the trans‐Golgi network or the plasma membrane, thus preventing unnecessary vacuolar degradation.
Dingyang Zhang +13 more
doaj +3 more sources
Pexophagy: Autophagic degradation of peroxisomes [PDF]
Biochimica Et Biophysica Acta - Molecular Cell Research, 2006 The abundance of peroxisomes within a cell can rapidly decrease by selective autophagic degradation (also designated pexophagy). Studies in yeast species have shown that at least two modes of peroxisome degradation are employed, namely macropexophagy and micropexophagy.
Yasuyoshi Sakai +2 more
exaly +4 more sources
The membrane peroxin PEX3 induces peroxisome-ubiquitination-linked pexophagy [PDF]
Autophagy, 2014 Peroxisomes are degraded by a selective type of autophagy known as pexophagy. Several different types of pexophagy have been reported in mammalian cells. However, the mechanisms underlying how peroxisomes are recognized by autophagy-related machinery remain elusive.
Yukio Fujiki
exaly +4 more sources
Segregation of pathways leading to pexophagy
Life Science Alliance, 2023 Pexophagy occurs via distinct NIX- and USP30/NBR1-dependent pathways. Peroxisomes are organelles with key roles in metabolism including long-chain fatty acid production.
Francesco G Barone +2 more
doaj +3 more sources
Autophagy in plants and algae [PDF]
Frontiers in Plant Science, 2014 Autophagy is a major cellular degradation pathway in which materials are delivered to the vacuole in double-membrane vesicles known as autophagosomes, broken down, and recycled (Li and Vierstra, 2012; Liu and Bassham, 2012).
Diane C Bassham, Jose Luis Crespo
doaj +8 more sources
Loss of HSPA9 induces peroxisomal degradation by increasing pexophagy [PDF]
Autophagy, 2020 Quality control of peroxisomes is essential for cellular homeostasis. However, the mechanism underlying pexophagy is largely unknown. In this study, we identified HSPA9 as a novel pexophagy regulator. Downregulation of HSPA9 increased macroautophagy/autophagy but decreased the number of peroxisomes in vitro and in vivo. The loss of peroxisomes by HSPA9
So Jung Park +2 more
exaly +4 more sources
Enhanced Levels of Peroxisome-Derived H2O2 Do Not Induce Pexophagy but Impair Autophagic Flux in HEK-293 and HeLa Cells [PDF]
Antioxidants, 2023 Peroxisomes are functionally specialized organelles that harbor multiple hydrogen peroxide (H2O2)-producing and -degrading enzymes. Given that this oxidant functions as a major redox signaling agent, peroxisomes have the intrinsic ability to mediate and ...
Hongli Li +5 more
doaj +2 more sources
Pexophagy: The Selective Degradation of Peroxisomes [PDF]
International Journal of Cell Biology, 2012 Peroxisomes are single-membrane-bounded organelles present in the majority of eukaryotic cells. Despite the existence of great diversity among different species, cell types, and under different environmental conditions, peroxisomes contain enzymes ...
Andreas Till +3 more
doaj +4 more sources
SIRT5-mediated desuccinylation of the porcine deltacoronavirus M protein drives pexophagy to enhance viral proliferation. [PDF]
PLoS PathogensPorcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus capable of infecting various animal species, including humans. In this study, we explored the roles of sirtuins (SIRTs), a conserved family of protein deacylases and mono ...
Zhuang Li +7 more
doaj +2 more sources
Peroxisome and pexophagy in neurological diseases
Fundamental ResearchPeroxisomes and pexophagy have gained increasing attention in their role within the central nervous system (CNS) in recent years. In this review, we comprehensively discussed the physiological and pathological mechanisms of peroxisomes and pexophagy in ...
Weilin Xu +8 more
doaj +3 more sources