Results 11 to 20 of about 4,212 (160)

Overexpression of the Selective Autophagy Cargo Receptor NBR1 Modifies Plant Response to Sulfur Deficit [PDF]

Cells, 2020
Plants exposed to sulfur deficit elevate the transcription of NBR1 what might reflect an increased demand for NBR1 in such conditions. Therefore, we investigated the role of this selective autophagy cargo receptor in plant response to sulfur deficit (-S).
Leszek Tarnowski, Milagros Collados Rodriguez, Jerzy Brzywczy, Dominik Cysewski, Anna Wawrzynska, Agnieszka Sirko   +5 more
doaj   +4 more sources

A role for the autophagy receptor NBR1 in the degradation of tau aggregates

Neurobiology of Disease
Neurofibrillary tangles (NFTs), comprising hyperphosphorylated and aggregated Tau protein, are a primary neuropathological feature of Alzheimer's Disease (AD).
Marie Neu, Iwan Parfentev, Gregory K. Potts, Nina Stöberl, Jürgen Korffmann, Andreas Striebinger, Daniela Geist, Dimitris Papageorgiou, Hanna Tarhonskaya, Nicholas McKitterick, Jeroen van Bergeijk, Christopher Untucht, Peter Reinhardt, Jon D. Williams, Michaela J. Heimann, Laura Gasparini, Dagmar E. Ehrnhoefer   +16 more
doaj   +3 more sources

NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ [PDF]

Nature Communications, 2021
p62 is a signaling hub protein that contributes to the control of energy expenditure. Here the authors investigate the relative roles of p62 and a similar protein, NBR1, and show that NBR1 is required for the repression of thermogenesis in adipocytes ...
Jianfeng Huang, Juan F. Linares, Angeles Duran, Wenmin Xia, Alan R. Saltiel, Timo D. Müller, Maria T. Diaz-Meco, Jorge Moscat   +7 more
doaj   +6 more sources

NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin

Chinese Medicine
Background Idiopathic pulmonary fibrosis is a persistent disease of the lung interstitium for which there is no efficacious pharmacological therapy. Protodioscin, a steroidal saponin, possesses diverse pharmacological properties; however, its function in
Qian Zeng, Bin-bin Wen, Xin Liu, Yong-yu Luo, Zhen-gang Hu, Lei Huang, Xiao-hua Zhang, Xiao-ting Huang, Ting-ting Zhou, Xiao-xue Sang, Yu-yang Luo, Da-yan Xiong, Zi-qiang Luo, Wei Liu, Si-yuan Tang   +14 more
doaj   +3 more sources

Mature-onset obesity in p62-deficient male mice maintains skeletal muscle mass despite metabolic dysfunction. [PDF]

Physiol Rep
Abstract Sequestosome 1 (p62/SQSTM1) is a multifunctional scaffolding protein at the intersection of autophagy and metabolic regulation. While p62 deficiency causes mature‐onset obesity and insulin resistance, its effects on skeletal muscle mass and function remain poorly understood.
Kim DH, Salazar G, Klemp A, Hwang HS, Yeh M, Panton LB, Kim JS.   +6 more
europepmc   +2 more sources

A Bacterial Effector Hijacks NBR1 to Modulate Both Autophagy and Ubiquitination-Mediated Degradation That Promotes Bacterial Infection. [PDF]

Plant Biotechnol J
ABSTRACT Autophagy and the ubiquitin/26S proteasome system (UPS) play critical roles in the immune defence of the host against pathogen invasion. As a countermeasure, pathogens deploy effector proteins to subvert or hijack autophagy and UPS processes.
Shi Y, Fang F, Cui X, Shi H, Yang Z, Li X, Zhou C, Wang X.   +7 more
europepmc   +2 more sources

NBR1: The archetypal selective autophagy receptor

Journal of Cell Biology, 2022
NBR1 was discovered as an autophagy receptor not long after the first described vertebrate autophagy receptor p62/SQSTM1. Since then, p62 has currently been mentioned in >10,000 papers on PubMed, while NBR1 is mentioned in <350 papers. Nonetheless, evolutionary analysis reveals that NBR1, and likely also selective autophagy, was present ...
Nikoline Lander Rasmussen, Athanasios Kournoutis, Trond Lamark, Terje Johansen   +3 more
openaire   +3 more sources

Crystal structure of the PB1 domain of NBR1 [PDF]

FEBS Letters, 2005
The scaffold protein NBR1 is involved in signal transmission downstream of the serine/protein kinase from the giant muscle protein titin. Its N‐terminal Phox and Bem1p (PB1) domain plays a critical role in mediating protein–protein interactions with both titin kinase and with another scaffold protein, p62.
Müller, Simone, Kursula, Inari, Zou, Peijian, Wilmanns, Matthias   +3 more
openaire   +2 more sources

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates [PDF]

Molecular Cell, 2009
Autophagy is a catabolic process where cytosolic cellular components are delivered to the lysosome for degradation. Recent studies have indicated the existence of specific receptors, such as p62, which link ubiquitinated targets to autophagosomal degradation pathways. Here we show that NBR1 (neighbor of BRCA1 gene 1) is an autophagy receptor containing
Kirkin, Vladimir, Lamark, Trond, Sou, Yu-Shin, Bjørkøy, Geir, Nunn, Jennifer L., Bruun, Jack-Ansgar, Shvets, Elena, McEwan, David G., Clausen, Terje H., Wild, Philipp, Bilusic, Ivana, Theurillat, Jean-Philippe, Øvervatn, Aud, Ishii, Tetsuro, Elazar, Zvulun, Komatsu, Masaaki, Dikic, Ivan, Johansen, Terje   +17 more
openaire   +3 more sources

Mitochondria-Related Pathogenic Genes in Paediatric Asthma: A Multi-Omics Mendelian Randomization Study. [PDF]

J Cell Mol Med
ABSTRACT Mitochondrial dysfunction is implicated in asthma pathogenesis, but causal roles of mitochondrial‐related genes in paediatric asthma remain unclear. We performed a multi‐omics Mendelian randomization study integrating GWAS data from paediatric asthma cohorts with blood‐based methylation quantitative trait loci (mQTLs), expression QTLs (eQTLs ...
Zhang B, Li Y, Ding B, Li X, Lu Y.
europepmc   +2 more sources