NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ [PDF]
Nature Communications, 2021 p62 is a signaling hub protein that contributes to the control of energy expenditure. Here the authors investigate the relative roles of p62 and a similar protein, NBR1, and show that NBR1 is required for the repression of thermogenesis in adipocytes ...
Jianfeng Huang +7 more
doaj +8 more sources
A role for the autophagy receptor NBR1 in the degradation of tau aggregates
Neurobiology of DiseaseNeurofibrillary tangles (NFTs), comprising hyperphosphorylated and aggregated Tau protein, are a primary neuropathological feature of Alzheimer's Disease (AD).
Marie Neu +16 more
doaj +4 more sources
NBR1: The archetypal selective autophagy receptor [PDF]
Journal of Cell Biology, 2022 NBR1 was discovered as an autophagy receptor not long after the first described vertebrate autophagy receptor p62/SQSTM1. Since then, p62 has currently been mentioned in >10,000 papers on PubMed, while NBR1 is mentioned in
Lamark, Trond +3 more
core +4 more sources
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates [PDF]
Molecular Cell, 2009 Autophagy is a catabolic process where cytosolic cellular components are delivered to the lysosome for degradation. Recent studies have indicated the existence of specific receptors, such as p62, which link ubiquitinated targets to autophagosomal ...
Theurillat, J P +4 more
core +5 more sources
Crystal structure of the PB1 domain of NBR1 [PDF]
FEBS Letters, 2006 The scaffold protein NBR1 is involved in signal transmission downstream of the serine/protein kinase from the giant muscle protein titin. Its N-terminal Phox and Bem1p (PB1) domain plays a critical role in mediating protein–protein interactions with both
Zou, Peijian +7 more
core +4 more sources
The autophagy receptor NBR1 directs the clearance of photodamaged chloroplasts
eLife, 2023 The ubiquitin-binding NBR1 autophagy receptor plays a prominent role in recognizing ubiquitylated protein aggregates for vacuolar degradation by macroautophagy.
Han Nim Lee +9 more
doaj +3 more sources
NBR1-mediated selective autophagy of ARF7 modulates root branching
EMBO Reports, 2022 Auxin dictates root architecture via the Auxin Response Factor (ARF) family of transcription factors, which control lateral root (LR) formation. In Arabidopsis, ARF7 regulates the specification of prebranch sites (PBS) generating LRs through gene ...
Ana Páez Garcia +2 more
exaly +8 more sources
Overexpression of the Selective Autophagy Cargo Receptor NBR1 Modifies Plant Response to Sulfur Deficit [PDF]
Cells, 2020 Plants exposed to sulfur deficit elevate the transcription of NBR1 what might reflect an increased demand for NBR1 in such conditions. Therefore, we investigated the role of this selective autophagy cargo receptor in plant response to sulfur deficit (-S).
Leszek Tarnowski +5 more
doaj +2 more sources
NBR1-mediated selective autophagy targets insoluble ubiquitinated protein aggregates in plant stress responses. [PDF]
PLoS Genetics, 2013 Plant autophagy plays an important role in delaying senescence, nutrient recycling, and stress responses. Functional analysis of plant autophagy has almost exclusively focused on the proteins required for the core process of autophagosome assembly, but ...
Jie Zhou +6 more
doaj +2 more sources
Structural mechanism of protein recognition by the FW domain of autophagy receptor Nbr1
Nature Communications, 2022 Nbr1 recognizes cargos in selective autophagy. Here, authors show filamentous yeast Nbr1 binds Ams1 via an FW domain, and the cryo-EM structure reveals that Nbr1 recognizes the N-terminal di-glycine and tetrameric assembly of Ams1.
Jianxiu Zhang +6 more
doaj +3 more sources