Results 41 to 50 of about 4,878 (179)

Tumor-associated macrophage-derived exosomes LINC01592 induce the immune escape of esophageal cancer by decreasing MHC-I surface expression

Journal of Experimental & Clinical Cancer Research, 2023
Background TAMs (tumor-associated macrophages) infiltration promotes the progression of esophageal cancer (EC). However, the underlying mechanisms remain unclear.
Xinwei Qiao, Zaixing Cheng, Kaming Xue, Cui Xiong, Zhikun Zheng, Xin Jin, Jinsong Li   +6 more
doaj   +1 more source

Stratification of diabetic kidney diseases via data-independent acquisition proteomics–based analysis of human kidney tissue specimens

Frontiers in Endocrinology, 2022
AimThe aims of this study were to analyze the proteomic differences in renal tissues from patients with diabetes mellitus (DM) and diabetic kidney disease (DKD) and to select sensitive biomarkers for early identification of DKD progression ...
Qinghua Huang, Qinghua Huang, Xianming Fei, Zhaoxian Zhong, Jieru Zhou, Jianguang Gong, Yuan Chen, Yiwen Li, Xiaohong Wu, Xiaohong Wu   +9 more
doaj   +1 more source

NBR1 co-operates with p62 in selective autophagy of ubiquitinated targets [PDF]

Autophagy, 2009
Selective degradation of intracellular targets, such as misfolded proteins and damaged organelles, is an important homeostatic function that autophagy has acquired in addition to its more general role in restoring the nutrient balance during stress and starvation.
Vladimir, Kirkin, Trond, Lamark, Terje, Johansen, Ivan, Dikic   +3 more
openaire   +2 more sources

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets [PDF]

Cell Cycle, 2009
Autophagy is an evolutionary conserved cell survival process for degradation of long-lived proteins, damaged organelles and protein aggregates. The mammalian proteins p62 and NBR1 are selectively degraded by autophagy and can act as cargo receptors or adaptors for the autophagic degradation of ubiquitinated substrates.
Trond, Lamark, Vladimir, Kirkin, Ivan, Dikic, Terje, Johansen   +3 more
openaire   +2 more sources

Role and Regulation of Autophagy in Heat Stress Responses of Tomato Plants

Frontiers in Plant Science, 2014
As sessile organisms, plants are constantly exposed to a wide spectrum of stress conditions such as high temperature, which causes protein misfolding.
Jie eZhou, Jian eWang, Jingquan eYu, Zhixiang eChen   +3 more
doaj   +1 more source

Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease

Neurobiology of Disease, 2013
Huntington's disease is characterized by the formation of protein aggregates, which can be degraded by macroautophagy. Here, we studied protein levels and intracellular distribution of p62 and NBR1, two macroautophagy cargo receptors, during disease ...
Laura Rué, Graciela López-Soop, Ellen Gelpi, Marta Martínez-Vicente, Jordi Alberch, Esther Pérez-Navarro   +5 more
doaj   +1 more source

Significant role of PB1 and UBA domains in multimerization of Joka2, a selective autophagy cargo receptor from tobacco

Frontiers in Plant Science, 2014
Tobacco Joka2 protein is a hybrid homolog of two mammalian selective autophagy cargo receptors, p62 and NBR1. These proteins can directly interact with the members of ATG8 family and the polyubiquitinated cargoes designed for degradation. Function of the
Katarzyna eZientara-Rytter, Agnieszka eSirko   +1 more
doaj   +1 more source

Molecular and structural mechanisms of ZZ domain‐mediated cargo selection by Nbr1

The EMBO Journal, 2021
In selective autophagy, cargo selectivity is determined by autophagy receptors. However, it remains scarcely understood how autophagy receptors recognize specific protein cargos. In the fission yeast Schizosaccharomyces pombe, a selective autophagy pathway termed Nbr1-mediated vacuolar targeting (NVT) employs Nbr1, an autophagy receptor conserved ...
Ying‐Ying Wang, Jianxiu Zhang, Xiao‐Man Liu, Yulu Li, Jianhua Sui, Meng‐Qiu Dong, Keqiong Ye, Li‐Lin Du   +7 more
openaire   +2 more sources

Molecular characterisation of ILRUN, a novel inhibitor of proinflammatory and antimicrobial cytokines

Heliyon, 2020
Regulation of type-I interferon (IFN) production is essential to the balance between antimicrobial defence and autoimmune disorders. The human protein-coding gene ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains, previously ...
Rebecca L. Ambrose, Aaron M. Brice, Alessandro T. Caputo, Marina R. Alexander, Leon Tribolet, Yu Chih Liu, Timothy E. Adams, Andrew G.D. Bean, Cameron R. Stewart   +8 more
doaj   +1 more source

Selective autophagy regulates heat stress memory in Arabidopsis by NBR1-mediated targeting of HSP90.1 and ROF1

, 2020
In nature, plants are constantly exposed to many transient, but recurring, stresses. Thus, to complete their life cycles, plants require a dynamic balance between capacities to recover following cessation of stress and maintenance of stress memory ...
Richard D. Vierstra (232311), Venkatesh P. Thirumalaikumar (9414070), Michal Gorka (9414073), Salma Balazadeh (434177), Arun Sampathkumar (9414082), Aleksandra Skirycz (58031), Karina Schulz (9414076), Celine Masclaux-Daubresse (9414079)   +7 more
core   +2 more sources