Results 41 to 50 of about 4,212 (160)

Significant role of PB1 and UBA domains in multimerization of Joka2, a selective autophagy cargo receptor from tobacco

Frontiers in Plant Science, 2014
Tobacco Joka2 protein is a hybrid homolog of two mammalian selective autophagy cargo receptors, p62 and NBR1. These proteins can directly interact with the members of ATG8 family and the polyubiquitinated cargoes designed for degradation. Function of the
Katarzyna eZientara-Rytter, Agnieszka eSirko   +1 more
doaj   +1 more source

Arabidopsis cargo receptor NBR1 mediates selective autophagy of defective proteins [PDF]

Journal of Experimental Botany, 2019
Arabidopsis cargo receptor NBR1 contributes to protein quality control by promoting the formation of protein aggregates and mediating their clearance via selective autophagy.
Jung, Hyera, Lee, Han Nim, Marshall, Richard S, Lomax, Aaron W, Yoon, Min Ji, Kim, Jimi, Kim, Jeong Hun, Vierstra, Richard D, Chung, Taijoon   +8 more
openaire   +2 more sources

MAP1B Interaction with the FW Domain of the Autophagic Receptor Nbr1 Facilitates Its Association to the Microtubule Network

International Journal of Cell Biology, 2012
Selective autophagy is a process whereby specific targeted cargo proteins, aggregates, or organelles are sequestered into double-membrane-bound phagophores before fusion with the lysosome for protein degradation.
Katie Marchbank, Sarah Waters, Roland G. Roberts, Ellen Solomon, Caroline A. Whitehouse   +4 more
doaj   +1 more source

Segregation of pathways leading to pexophagy

Life Science Alliance, 2023
Pexophagy occurs via distinct NIX- and USP30/NBR1-dependent pathways. Peroxisomes are organelles with key roles in metabolism including long-chain fatty acid production.
Francesco G Barone, Sylvie Urbé, Michael J Clague   +2 more
doaj   +1 more source

Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation

Nature Communications, 2021
Misfolded proteins are ubquitinated and subsequently condensed by cargo receptors for selective autophagy. Here, the authors use in vitro reconstitution to elegantly dissect how the receptors p62/SQSTM1, NBR1 and TAX1BP1 contribute to p62-ubiquitin ...
Eleonora Turco, Adriana Savova, Flora Gere, Luca Ferrari, Julia Romanov, Martina Schuschnig, Sascha Martens   +6 more
doaj   +1 more source

The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation.

PLoS Pathogens, 2021
Influenza A virus (IAV) has evolved various strategies to counteract the innate immune response using different viral proteins. However, the mechanism is not fully elucidated.
Yan Zeng, Shuai Xu, Yanli Wei, Xuegang Zhang, Qian Wang, Yane Jia, Wanbing Wang, Lu Han, Zhaoshan Chen, Zhengxiang Wang, Bo Zhang, Hualan Chen, Cao-Qi Lei, Qiyun Zhu   +13 more
doaj   +1 more source

NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1 [PDF]

Cell Death & Disease, 2015
AbstractDegradation of malfunctional mitochondria by mitophagy is a pivotal component of mitochondrial quality control to maintain cellular homeostasis. Mitochondrial clearance through the PINK1/PARK2 pathway is mediated by autophagic adaptor proteins.
Shi, J, Fung, G, Deng, H, Zhang, J, Fiesel, F C, Springer, W, Li, X, Luo, H   +7 more
openaire   +2 more sources

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

β‐Aminoisobutyric Acid Alleviates Cisplatin‐Induced Muscle Atrophy by Regulating E3 Ubiquitin Ligases, Apoptosis, Amino Acid Metabolism, Autophagy, and Ferroptosis

Medicine Bulletin, EarlyView.
ABSTRACT Background Cisplatin (CIS) is a widely used broad‐spectrum anticancer agent, but its clinical application is often limited by severe adverse effects, including skeletal muscle atrophy, which compromises patients' quality of life and treatment efficacy.
Hao‐Zhe Wang, Wen‐Bi He, Huan Wang, Hao Wang, Wen‐Jun Fang, Meng‐Qian Li, Jiong‐Xing Huang, Fei‐Peng Chen, Hui‐Guo Wang, Lin Zhu, Xiao‐Guang Liu   +10 more
wiley   +1 more source

Nbr1, a Receptor for ESCRT-Dependent Endosomal Microautophagy in Fission Yeast [PDF]

Molecular Cell, 2015
In this issue of Molecular Cell, Liu et al. (2015) report that fission yeast Nbr1, sharing a partial homology to the mammalian macroautophagy receptor NBR1, acts as a receptor for ESCRT-dependent endosomal microautophagy that delivers two hydrolytic enzymes from the cytosol to the vacuole.
openaire   +2 more sources