Results 51 to 60 of about 4,878 (179)
Cytotoxic effect of Ziziphus Spina-Christi extract alone and in combination with doxorubicin on breast cancer cells [PDF]
The Ukrainian Biochemical Journal, 2023 Ziziphus Spina-Christi (L.) (ZSC) is a traditional Arabian medicinal plant used to treat inflammatory symptoms, swellings and pain since long. Triple negative breast cancer (TNBC) is a form of cancer with a poor prognosis owing to the paucity of therapy ...
E. S. El-Shafey, E. S. Elsherbiny
doaj +1 more source
International Journal of Cell Biology, 2012 Selective autophagy is a process whereby specific targeted cargo proteins, aggregates, or organelles are sequestered into double-membrane-bound phagophores before fusion with the lysosome for protein degradation.
Katie Marchbank +4 more
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Segregation of pathways leading to pexophagy
Life Science Alliance, 2023 Pexophagy occurs via distinct NIX- and USP30/NBR1-dependent pathways. Peroxisomes are organelles with key roles in metabolism including long-chain fatty acid production.
Francesco G Barone +2 more
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Nature Communications, 2021 Misfolded proteins are ubquitinated and subsequently condensed by cargo receptors for selective autophagy. Here, the authors use in vitro reconstitution to elegantly dissect how the receptors p62/SQSTM1, NBR1 and TAX1BP1 contribute to p62-ubiquitin ...
Eleonora Turco +6 more
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Loss of p62 impairs recruitment of NBR1 to MDBs.
, 2016 (A). The scheme (modified from [34]) depicts the protein domain architecture of NBR1 and p62. The reported interaction partners and conserved domains are highlighted by double headed arrows and gray boxes, respectively.
Leopold F. Fröhlich (283489) +8 more
core +1 more source
Arabidopsis cargo receptor NBR1 mediates selective autophagy of defective proteins [PDF]
Journal of Experimental Botany, 2019 Arabidopsis cargo receptor NBR1 contributes to protein quality control by promoting the formation of protein aggregates and mediating their clearance via selective autophagy.
Jung, Hyera +8 more
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PLoS Pathogens, 2021 Influenza A virus (IAV) has evolved various strategies to counteract the innate immune response using different viral proteins. However, the mechanism is not fully elucidated.
Yan Zeng +13 more
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Nbr1, a Receptor for ESCRT-Dependent Endosomal Microautophagy in Fission Yeast [PDF]
Molecular Cell, 2015 In this issue of Molecular Cell, Liu et al. (2015) report that fission yeast Nbr1, sharing a partial homology to the mammalian macroautophagy receptor NBR1, acts as a receptor for ESCRT-dependent endosomal microautophagy that delivers two hydrolytic enzymes from the cytosol to the vacuole.
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NBR1‐mediated p62‐liquid droplets enhance the Keap1‐Nrf2 system
The EMBO Reports, 2020 p62/SQSTM1 is a multivalent protein that has the ability to cause liquid-liquid phase separation and serves as a receptor protein that participates in cargo isolation during selective autophagy. This protein is also involved in the non-canonical activation of the Keap1-Nrf2 system, a major oxidative stress response pathway.
Pablo Sánchez‐Martín +5 more
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NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1 [PDF]
Cell Death & Disease, 2015 AbstractDegradation of malfunctional mitochondria by mitophagy is a pivotal component of mitochondrial quality control to maintain cellular homeostasis. Mitochondrial clearance through the PINK1/PARK2 pathway is mediated by autophagic adaptor proteins.
Shi, J +7 more
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