Results 71 to 80 of about 4,878 (179)

Peroxin 14 tags peroxisomes and interacts with Nbr1 for pexophagy in the filamentous insect pathogenic fungus Beauveria bassiana

Autophagy Reports, 2023
Pexophagy is a main pathway for selective degradation of peroxisomes. However, the molecular mechanisms underlying pexophagy remain fragmented in the filamentous fungi.
Hai-Yan Lin, Jia-Hui Lei, Jin-Li Ding, Yue-Jin Peng, Hao Zhang, Ming-Guang Feng, Sheng-Hua Ying   +6 more
doaj   +1 more source

The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong, Zhen Wang, Xiaoxiao Lin, Ziwen Lei, Qianqian Huang, Hang Liu, Fei Luan, Junbo Zou, Yajun Shi   +8 more
wiley   +1 more source

Oligomerization of Selective Autophagy Receptors for the Targeting and Degradation of Protein Aggregates

Cells, 2021
The selective targeting and disposal of solid protein aggregates are essential for cells to maintain protein homoeostasis. Autophagy receptors including p62, NBR1, Cue5/TOLLIP (CUET), and Tax1-binding protein 1 (TAX1BP1) proteins function in selective ...
Wenjun Chen, Tianyun Shen, Lijun Wang, Kefeng Lu   +3 more
doaj   +1 more source

Unfolding Plant Defence: Endoplasmic Reticulum Stress Signalling at the Plant‐Pathogen Interface

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4799-4822, August 2026.
ABSTRACT The endoplasmic reticulum (ER) stress response, a conserved proteostasis network, has emerged as a central hub that reprograms plant immunity during pathogen attack. This review synthesises how plants harness ER‐stress signalling to mount multilayered defences and how pathogens have evolved counterstrategies to subvert these pathways.
Zhe Meng, Shuqin Zheng, Federica Brandizzi, Yiran Liu, Chunlei Li, Congcong Ai, Yujiao Wang, Jiadong Qi, Xiuguo Zhang   +8 more
wiley   +1 more source

Neuroprotective Mechanisms of Calycosin Against Focal Cerebral Ischemia and Reperfusion Injury in Rats

Cellular Physiology and Biochemistry, 2018
Background/Aims: Emerging evidence suggests that autophagy plays important roles in the pathophysiological processes of cerebral ischemia and reperfusion injury.
Yong Wang, Qianyao Ren, Xing Zhang, Huiling Lu, Jian Chen   +4 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, Volume 600, Issue 13, Page 1829-1841, July 2026.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Membrane Contact Sites and Organelles Interaction in Plant Autophagy

Frontiers in Plant Science, 2020
Autophagy is an intracellular trafficking and degradation system for recycling of damaged organelles, mis-folded proteins and cytoplasmic constituents. Autophagy can be divided into non-selective autophagy and selective autophagy according to the cargo ...
Hao Ye, Changyang Ji, Rongfang Guo, Rongfang Guo, Liwen Jiang, Liwen Jiang   +5 more
doaj   +1 more source

The SQSTM1 L341V Variant Associated With Sporadic ALS Promotes the Accumulation of Enlarged Ubiquitin‐Positive SQSTM1 Bodies

Genes to Cells, Volume 31, Issue 4, July 2026.
WT SQSTM1 binds to polyubiquitinated cargo and recruits both the cargo and itself to the autophagy‐endolysosomal system (left). In contrast, a fraction of the L341V variant fails to be recruited to autophagosomes and instead forms ubiquitin‐positive large structures (right).
Kento Shimakura, Akira Oka, Haruka Yudahira, Yutaro Hama, Asako Otomo, Shinji Hadano   +5 more
wiley   +1 more source

Multiaxial Biophysical Control of Oncogenic Phase Separation by Indoleamines: A Proof‐of‐Concept Synthesis of Landscape‐Level Regulation

Journal of Pineal Research, Volume 78, Issue 4, July 2026.
ABSTRACT Oncogenic condensates act as biophysical sanctuaries that stabilize malignant survival programs. However, a universal regulator capable of orchestrating the integrated biophysical axes governing cellular phase behavior has remained elusive.
Doris Loh, Luiz Gustavo de Almeida Chuffa, Fábio Rodrigues Ferreira Seiva, Russel J. Reiter   +3 more
wiley   +1 more source

Genotype-Specific Activation of Autophagy during Heat Wave in Wheat

Cells
Recycling of unnecessary or dysfunctional cellular structures through autophagy plays a critical role in cellular homeostasis and environmental resilience.
Kathleen Hickey, Yunus Şahin, Glenn Turner, Taras Nazarov, Vadim Jitkov, Mike Pumphrey, Andrei Smertenko   +6 more
doaj   +1 more source