Results 81 to 90 of about 4,878 (179)
Plants, 2020 Phosphoenolpyruvate carboxylase (PEPC) is an enzyme with key roles in carbon and nitrogen metabolisms. The mechanisms that control enzyme stability and turnover are not well known.
Guillermo Baena +6 more
doaj +1 more source
Medicine Bulletin, Volume 2, Issue 3, Page 256-267, June 2026.ABSTRACT Background Cisplatin (CIS) is a widely used broad‐spectrum anticancer agent, but its clinical application is often limited by severe adverse effects, including skeletal muscle atrophy, which compromises patients' quality of life and treatment efficacy.
Hao‐Zhe Wang +10 more
wiley +1 more source
The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies
MedComm – Oncology, Volume 5, Issue 2, June 2026.Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao +4 more
wiley +1 more source
Dengue Virus Utilizes NBR1 During Induced Lipophagy and for Viral Egress [PDF]
Dengue virus (DENV) infection induces a proviral lipophagy to mobilize lipids from the lipid droplet. Τhis study demonstrates that the selective autophagy receptor Neighbor of BRCA 1 (NBR1) is recruited to lipid droplets after DENV infection.
Hackney, Joshua
core +1 more source
A Model of Autophagy Size Selectivity by Receptor Clustering on Peroxisomes
Frontiers in Physics, 2017 Selective autophagy must not only select the correct type of organelle, but also must discriminate between individual organelles of the same kind so that some but not all of the organelles are removed.
Aidan I. Brown +2 more
doaj +1 more source
Advanced Science, Volume 13, Issue 27, 13 May 2026.Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji +10 more
wiley +1 more source
小而密低密度脂蛋白胆固醇对冠状动脉粥样硬化患者自噬诱导作用研究
Zhongguo shiyan zhenduanxue, 2021 目的探究小而密低密度脂蛋白胆固醇(sd LDL-C)对冠状动脉粥样硬化患者自噬诱导作用。方法选取自2018年1月1日-2020年5月30日间吉林大学第二医院收治拟行经皮冠状动脉介入术(PCI)的冠状动脉粥样硬化患者78例(粥样硬化组)和非粥样硬化冠脉病变患者45例(对照组)作为研究对象。观察两组患者血清sd LDL-C和冠脉标本中自噬相关蛋白表达水平。通过对粥样硬化组患者进行病变支数和狭窄程度亚组分析,观察其与sd LDL-C和自噬相关蛋白的相关性。结果粥样硬化组患者血清sd LDL-C、p62 ...
郭迎雪, 李俊峰, 高艺航, 邓沫
doaj
The Hemoprotein Hhy1 Promotes Heme‐Dependent Catalase Activity of Ctt1
Molecular Microbiology, Volume 125, Issue 5, Page 389-411, May 2026.A Schizosaccharomyces pombe strain deficient in heme (hem1Δ) and siderophore (Fc) biosynthesis, as well as high‐affinity iron (Fe) uptake (blue), was used to uncover the hemoprotein Hhy1 that promotes the heme‐dependent activity of the catalase Ctt1. In contrast, hhy1Δ cells exhibit reduced Ctt1 activity and increased sensitivity to oxidative stress ...
Tobias Vahsen +3 more
wiley +1 more source
UMYU Scientifica JournalHepatocellular carcinoma (HCC), among the top causes of cancer-associated mortality globally, lacks effective treatment, especially at an advanced stage.
Omorodion, N. T. +2 more
doaj +1 more source
Advanced Science, Volume 13, Issue 24, 27 April 2026.MoHrd3 plays a crucial role in regulating the pathogenicity of Magnaporthe oryzae. As an ER‐associated degradation component, MoHrd3 involves in ER stress‐triggered autophagy. It facilitates the fusion between the autophagosome and the vacuole via enhancing the interaction between MoAtg8 and MoYpt7.
Huiqing Xia +11 more
wiley +1 more source