Results 81 to 90 of about 4,212 (160)

Subversion of selective autophagy for the biogenesis of tombusvirus replication organelles inhibits autophagy.

PLoS Pathogens
Elaborate viral replication organelles (VROs) are formed to support positive-strand RNA virus replication in infected cells. VRO formation requires subversion of intracellular membranes by viral replication proteins.
Yuanrong Kang, Wenwu Lin, Peter D Nagy
doaj   +1 more source

Recruitment of autophagy initiator TAX1BP1 advances aggrephagy from cargo collection to sequestration

The EMBO Journal
Autophagy mediates the degradation of harmful material within lysosomes. In aggrephagy, the pathway mediating the degradation of aggregated, ubiquitinated proteins, this cargo material is collected in larger condensates prior to its sequestration by ...
Bernd Bauer, Jonas Idinger, Martina Schuschnig, Luca Ferrari, Sascha Martens   +4 more
doaj   +1 more source

Autophagy turns specific: the discovery of p62 and NBR1 as autophagy cargo receptors [PDF]

BMC Proceedings, 2010
Cellular proteins and organelles are constantly damaged as a result of cell-stress, expression of mutated genes or aging by itself. Autophagy is the principle cellular mechanism for turnover of damaged organelles and long-lived proteins. Autophagy is initiated by the formation of a cytoplasmic double membrane that grows to make a double membrane ...
openaire   +1 more source

Gains of ubiquitylation sites in highly conserved proteins in the human lineage

BMC Bioinformatics, 2012
Background Post-translational modification of lysine residues of specific proteins by ubiquitin modulates the degradation, localization, and activity of these target proteins.
Kim Dong Seon, Hahn Yoonsoo
doaj   +1 more source

Peroxisome Proliferator Activator α Agonist Clofibrate Induces Pexophagy in Coconut Oil-Based High-Fat Diet-Fed Rats

Biology
Peroxisomes are crucial for fatty acid β-oxidation in steatosis, but the role of pexophagy—the selective autophagy of peroxisomes—remains unclear. This study investigated the effects of the peroxisome proliferator-activated receptor-α (PPARα) agonist ...
Kanami Ohshima, Emika Hara, Mio Takimoto, Yidan Bai, Mai Hirata, Wen Zeng, Suzuka Uomoto, Mai Todoroki, Mio Kobayashi, Takuma Kozono, Tetsuhito Kigata, Makoto Shibutani, Toshinori Yoshida   +12 more
doaj   +1 more source

Identification of autophagy receptors for the Crohn’s disease-associated adherent-invasive Escherichia coli

Frontiers in Cellular and Infection Microbiology
IntroductionCrohn’s disease (CD) is a chronic inflammatory bowel disease, of which the etiology involves genetic, environmental and microbial factors.
Alison Da Silva, Guillaume Dalmasso, Anaïs Larabi, My Hanh Thi Hoang, My Hanh Thi Hoang, Elisabeth Billard, Nicolas Barnich, Hang Thi Thu Nguyen   +7 more
doaj   +1 more source

Particulate matter-induced NETosis promotes peroxisomal degradation via pexophagy in neutrophils

Ecotoxicology and Environmental Safety
Neutrophil extracellular traps (NETs) are chomatin-based structures that contribute to the defense mechanisms of a host; however, NETs can also drive inflammation when dysregulated. Particulate matter (PM), a major air pollutant, has been shown to induce
Yeji Shin, Kahyun Kim, Jisoo Han, Byounghwa Kim, Hyun Joung Lim, Jae-Young Um, Inhyung Lee, Hyun Jeong Kwak   +7 more
doaj   +1 more source

Characterization of the Arabidopsis thaliana homologue of NBR1

, 2009
It is now well established that p62 and NBR1 are selectively degraded by autophagy and can act as cargo receptors or adaptors for the autophagic degradation of ubiquitinated substrates. Research on autophagy in plants is also well under way, but the mechanism by which target substrates are sequestered for autophagic degradation has not been elucidated.
openaire   +1 more source

Fish LASP1 promotes NBR1-mediated MAVS autophagic degradation to inhibit IFN production

Water Biology and Security
The mitochondrial antiviral signaling protein (MAVS) plays a pivotal role in the interferon (IFN) activation signaling pathway, which culminates in the production of IFN and the establishment of a positive feedback loop.
Dan-Dan Chen, Jing-Shuai Li, Jia-Xin Zhang, Lan-Xiang Jin, Zhuo-Cong Li, Can Zhang, Xiao Xu, Bao-Jie Cui, Yang-Yang Wang, Chu-Jing Zhou, Long-Feng Lu, Rong Zhu, Shun Li   +12 more
doaj   +1 more source

Repeat Expansions in PLIN4 Cause Autosomal Dominant Vacuolar Myopathy With Sarcolemmal Features

Annals of Clinical and Translational Neurology
Objective We aim to describe and characterize two unrelated Spanish families suffering from an autosomal dominant autophagic vacuolar myopathy caused by repeat expansions in PLIN4.
Laura Llansó, Igor Stevanovski, Germán Morís, Roger Collet‐Vidiella, Alba Segarra‐Casas, Lidia González‐Quereda, Benjamín Rodríguez‐Santiago, Pia Gallano, Rodrigo Alvarez, Ana Vesperinas, Rosa Blanco, Beatriz San‐Millán, Carmen Navarro, Isabel Illa, Gianina Ravenscroft, Ira W. Deveson, Eduard Gallardo, Montse Olivé   +17 more
doaj   +1 more source