Results 91 to 100 of about 4,878 (179)

The effect of NBR1 on tombusvirus replication in N. benthamiana plants.

(A) Top panel: The accumulation of TBSV RNAs in NBR1-silenced (NBR1 KD) inoculated leaves of N. benthamiana at 2 dpi was measured by northern blot analysis. Sap inoculation with TBSV was done 10 days after silencing of NBR1 expression.
Peter D. Nagy (7542872), Yuanrong Kang (6590813), Wenwu Lin (7542863)   +2 more
core   +1 more source

LSU family members and NBR1 are novel factors that contribute to homeostasis of catalases and peroxisomes in Arabidopsis thaliana

Scientific Reports
The short coiled-coil LSU (RESPONSE TO LOW SULFUR) proteins are linked to sulfur metabolism and have numerous protein partners. However, most of these partners lack direct links to sulfur metabolism, and the role of such interactions remains elusive ...
Anna Niemiro, Konrad Jurczewski, Marzena Sieńko, Anna Wawrzyńska, Marcin Olszak, Jarosław Poznański, Agnieszka Sirko   +6 more
doaj   +1 more source

Requirement of the LIR motif for the critical role of NBR1 in heat tolerance.

, 2013
(A) Diagrams of wild-type and mutant NBR1 proteins. The conserved W and I residues in the LIR motif between the two UBA domains were changed to A residues in the NBR1W661A/I664A (mNBR1) mutant protein. (B) Five weeks-old Arabidopsis Col-0 wild type (WT),
Jing-Quan Yu (102564), Yuan Cheng (72244), Zhixiang Chen (23839), Ying-Jun Chi (102562), Baofang Fan (23837), Jian Wang (5901), Jie Zhou (28945)   +6 more
core   +1 more source

Subversion of selective autophagy for the biogenesis of tombusvirus replication organelles inhibits autophagy.

PLoS Pathogens
Elaborate viral replication organelles (VROs) are formed to support positive-strand RNA virus replication in infected cells. VRO formation requires subversion of intracellular membranes by viral replication proteins.
Yuanrong Kang, Wenwu Lin, Peter D Nagy
doaj   +1 more source

A proposed model for CHIP- and NBR1-mediated antiproteotoxic pathways.

, 2014
Stress conditions such as high temperature cause generation of misfolded and damaged proteins. Chaperone-associated E3 ubiquitin ligase CHIP ubiquitinates soluble misfolded proteins that are associated with chaperone molecules and targets their ...
Jing-Quan Yu (102564), Yan Zhang (8098), Zhixiang Chen (23839), Jingxia Qi (517498), Yingjin Chi (517499), Baofang Fan (23837), Jie Zhou (28945)   +6 more
core   +1 more source

NBR1 helps autophagosomes take a bite out of focal adhesions [PDF]

Journal of Cell Biology, 2016
![Figure][1] Autophagosomes (black) target focal adhesions (magenta) at the leading edge of a migrating cell. [Kenific et al.][2] identify a selective autophagy pathway that promotes cell migration by enhancing the turnover of focal adhesions.
openaire   +1 more source

Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity

, 2010
The neighbor of Brca1 gene (Nbr1) functions as an autophagy receptor involved in targeting ubiquitinated proteins for degradation. It also has a dual role as a scaffold protein to regulate growth-factor receptor and downstream signaling ...
Agamemnon E. Grigoriadis, Ellen Solomon, Alan Horner, Cobourne, Martyn T.; id_orcid, Machado Xavier, Guilherme, Martyn T. Cobourne, Jovanovic, Jelena V., Guilherme M. Xavier, Richards, Gareth O., Sarah Waters, Marchbank, Katie, McGowan, Neil W. A., Solomon, Ellen, Katie Marchbank, Paul T. Sharpe, Waters, Sarah, Sharpe, Paul T., Jelena V. Jovanovic, Horner, Alan, Caroline A. Whitehouse, Takeshi G. Kashima, Tim M. Skerry, Neil W. A. McGowan, Grigoriadis, Agamemnon E., Kashima, Takeshi G., Skerry, Tim M., Whitehouse, Caroline A., Gareth O. Richards   +27 more
core   +1 more source

Recruitment of autophagy initiator TAX1BP1 advances aggrephagy from cargo collection to sequestration

The EMBO Journal
Autophagy mediates the degradation of harmful material within lysosomes. In aggrephagy, the pathway mediating the degradation of aggregated, ubiquitinated proteins, this cargo material is collected in larger condensates prior to its sequestration by ...
Bernd Bauer, Jonas Idinger, Martina Schuschnig, Luca Ferrari, Sascha Martens   +4 more
doaj   +1 more source

Autophagy turns specific: the discovery of p62 and NBR1 as autophagy cargo receptors [PDF]

BMC Proceedings, 2010
Cellular proteins and organelles are constantly damaged as a result of cell-stress, expression of mutated genes or aging by itself. Autophagy is the principle cellular mechanism for turnover of damaged organelles and long-lived proteins. Autophagy is initiated by the formation of a cytoplasmic double membrane that grows to make a double membrane ...
openaire   +1 more source

Intronic T-DNA insertion in Arabidopsis NBR1 conditionally affects wild-type transcript level [PDF]

, 2014
The SALK_135513 line of Arabidopsis thaliana is annotated by GenBank to have the T-DNA insertion in the fourth exon of NBR1 (At4g24690). Careful molecular analyses of the homozygous plants of SALK_135513 line indicated the place of T-DNA insertion in ...
Sirko, Agnieszka, Collados Rodríguez, Milagros, Wawrzyńska, Anna   +2 more
core   +1 more source