Results 61 to 70 of about 4,212 (160)
Expression of BRCA1, NBR1 and NBR2 Genes in Human Breast Cancer Cells
Folia Biologica, 2001 BRCA1 is a tumour suppressor gene with a caretaker function in the DNA-damage repair and the maintenance of genome integrity. The human BRCA1 and NBR2 genes and the homologous Brca1 and Nbr1 mouse genes are situated head-to-head on ...
S D, Dimitrov, E, Matousková, J, Forejt
openaire +2 more sources
Advanced Science, Volume 13, Issue 27, 13 May 2026.Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji +10 more
wiley +1 more source
Membrane Contact Sites and Organelles Interaction in Plant Autophagy
Frontiers in Plant Science, 2020 Autophagy is an intracellular trafficking and degradation system for recycling of damaged organelles, mis-folded proteins and cytoplasmic constituents. Autophagy can be divided into non-selective autophagy and selective autophagy according to the cargo ...
Hao Ye +5 more
doaj +1 more source
The Hemoprotein Hhy1 Promotes Heme‐Dependent Catalase Activity of Ctt1
Molecular Microbiology, Volume 125, Issue 5, Page 389-411, May 2026.A Schizosaccharomyces pombe strain deficient in heme (hem1Δ) and siderophore (Fc) biosynthesis, as well as high‐affinity iron (Fe) uptake (blue), was used to uncover the hemoprotein Hhy1 that promotes the heme‐dependent activity of the catalase Ctt1. In contrast, hhy1Δ cells exhibit reduced Ctt1 activity and increased sensitivity to oxidative stress ...
Tobias Vahsen +3 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Emerging evidence suggests that autophagy plays important roles in the pathophysiological processes of cerebral ischemia and reperfusion injury.
Yong Wang +4 more
doaj +1 more source
Advanced Science, Volume 13, Issue 24, 27 April 2026.MoHrd3 plays a crucial role in regulating the pathogenicity of Magnaporthe oryzae. As an ER‐associated degradation component, MoHrd3 involves in ER stress‐triggered autophagy. It facilitates the fusion between the autophagosome and the vacuole via enhancing the interaction between MoAtg8 and MoYpt7.
Huiqing Xia +11 more
wiley +1 more source
Plants, 2020 Phosphoenolpyruvate carboxylase (PEPC) is an enzyme with key roles in carbon and nitrogen metabolisms. The mechanisms that control enzyme stability and turnover are not well known.
Guillermo Baena +6 more
doaj +1 more source
Genotype-Specific Activation of Autophagy during Heat Wave in Wheat
CellsRecycling of unnecessary or dysfunctional cellular structures through autophagy plays a critical role in cellular homeostasis and environmental resilience.
Kathleen Hickey +6 more
doaj +1 more source
Advanced Science, Volume 13, Issue 16, 18 March 2026.Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera +10 more
wiley +1 more source
A Model of Autophagy Size Selectivity by Receptor Clustering on Peroxisomes
Frontiers in Physics, 2017 Selective autophagy must not only select the correct type of organelle, but also must discriminate between individual organelles of the same kind so that some but not all of the organelles are removed.
Aidan I. Brown +2 more
doaj +1 more source