Results 31 to 40 of about 4,212 (160)
NBR1 co-operates with p62 in selective autophagy of ubiquitinated targets [PDF]
Autophagy, 2009 Selective degradation of intracellular targets, such as misfolded proteins and damaged organelles, is an important homeostatic function that autophagy has acquired in addition to its more general role in restoring the nutrient balance during stress and starvation.
Vladimir, Kirkin +3 more
openaire +2 more sources
HIPK2 Is Required for Midbody Remnant Removal Through Autophagy-Mediated Degradation
Frontiers in Cell and Developmental Biology, 2020 At the end of abscission, the residual midbody forms the so-called midbody remnant (MBR), a platform affecting cell fate with emerging key role in differentiation, development, and tumorigenicity.
Francesca Sardina +6 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2023 Background TAMs (tumor-associated macrophages) infiltration promotes the progression of esophageal cancer (EC). However, the underlying mechanisms remain unclear.
Xinwei Qiao +6 more
doaj +1 more source
Cleavage of the selective autophagy receptor NBR1 by the PDCoV main protease NSP5 impairs autophagic degradation of the viral envelope protein [PDF]
AutophagySizhu Suolang
exaly +2 more sources
Role and Regulation of Autophagy in Heat Stress Responses of Tomato Plants
Frontiers in Plant Science, 2014 As sessile organisms, plants are constantly exposed to a wide spectrum of stress conditions such as high temperature, which causes protein misfolding.
Jie eZhou +3 more
doaj +1 more source
NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets [PDF]
Cell Cycle, 2009 Autophagy is an evolutionary conserved cell survival process for degradation of long-lived proteins, damaged organelles and protein aggregates. The mammalian proteins p62 and NBR1 are selectively degraded by autophagy and can act as cargo receptors or adaptors for the autophagic degradation of ubiquitinated substrates.
Trond, Lamark +3 more
openaire +2 more sources
Neurobiology of Disease, 2013 Huntington's disease is characterized by the formation of protein aggregates, which can be degraded by macroautophagy. Here, we studied protein levels and intracellular distribution of p62 and NBR1, two macroautophagy cargo receptors, during disease ...
Laura Rué +5 more
doaj +1 more source
Cytotoxic effect of Ziziphus Spina-Christi extract alone and in combination with doxorubicin on breast cancer cells [PDF]
The Ukrainian Biochemical Journal, 2023 Ziziphus Spina-Christi (L.) (ZSC) is a traditional Arabian medicinal plant used to treat inflammatory symptoms, swellings and pain since long. Triple negative breast cancer (TNBC) is a form of cancer with a poor prognosis owing to the paucity of therapy ...
E. S. El-Shafey, E. S. Elsherbiny
doaj +1 more source
Heliyon, 2020 Regulation of type-I interferon (IFN) production is essential to the balance between antimicrobial defence and autoimmune disorders. The human protein-coding gene ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains, previously ...
Rebecca L. Ambrose +8 more
doaj +1 more source
Molecular and structural mechanisms of ZZ domain‐mediated cargo selection by Nbr1
The EMBO Journal, 2021 In selective autophagy, cargo selectivity is determined by autophagy receptors. However, it remains scarcely understood how autophagy receptors recognize specific protein cargos. In the fission yeast Schizosaccharomyces pombe, a selective autophagy pathway termed Nbr1-mediated vacuolar targeting (NVT) employs Nbr1, an autophagy receptor conserved ...
Ying‐Ying Wang +7 more
openaire +2 more sources