Results 31 to 40 of about 4,878 (179)
NBR1 acts as an autophagy receptor for peroxisomes [PDF]
Journal of Cell Science, 2012 Selective macro-autophagy is an intracellular process by which large cytoplasmic materials are selectively sequestered and degraded in the lysosomes. Substrate selection is mediated by ubiquitination and recruitment of ubiquitin-binding autophagic receptors such as p62, NBR1, NDP52 and Optineurin.
Elizabeth, Deosaran +12 more
openaire +2 more sources
Frontiers in Immunology, 2021 Autophagy is a proposed route of amyloid-β (Aβ) clearance by microglia that is halted in Alzheimer’s Disease (AD), though mechanisms underlying this dysfunction remain elusive.
Shady Estfanous +27 more
doaj +1 more source
Plant NBR1 is a selective autophagy substrate and a functional hybrid of the mammalian autophagic adapters NBR1 and p62/SQSTM1 [PDF]
Autophagy, 2011 (Macro)autophagy encompasses both an unselective, bulk degradation of cytoplasmic contents as well as selective autophagy of damaged organelles, intracellular microbes, protein aggregates, cellular structures and specific soluble proteins. Selective autophagy is mediated by autophagic adapters, like p62/SQSTM1 and NBR1.
Steingrim, Svenning +3 more
openaire +2 more sources
Implications of Selective Autophagy Dysfunction for ALS Pathology
Cells, 2020 Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. Due to the biological complexity of the disease, its etiology remains unknown.
Emiliano Vicencio +5 more
doaj +1 more source
NBR1-mediated antiviral xenophagy in plant immunity [PDF]
Autophagy, 2017 Macroautophagy/autophagy intersects with metazoan virus infections in highly complex and multifaceted ways. Autophagy mechanisms are part of antiviral immunity, but can be manipulated by several viruses to the benefit of infection. In plants, however, the roles of autophagy in virus infections have only recently started to emerge.
Anders, Hafrén, Daniel, Hofius
openaire +2 more sources
TRAF3 and NBR1 both influence the effect of the disease-causing CYLD(Arg936X) mutation on NF-κB activity [PDF]
, 2021 \ua9 2021 The Authors. Experimental Dermatology published by John Wiley & Sons Ltd.Recently described Hungarian and Anglo-Saxon pedigrees that are affected by CYLD cutaneous syndrome (syn: Brooke-Spiegler syndrome (BSS)) carry the same disease ...
Nagy N +5 more
core +5 more sources
A Macrophage NBR1-MEKK3 Complex Triggers JNK-Mediated Adipose Tissue Inflammation in Obesity [PDF]
, 2014 SummaryThe c-Jun NH(2)-terminal kinase (JNK) is a critical determinant of obesity-associated inflammation and glucose intolerance. The upstream mechanisms controlling this pathway are still unknown.
Yajima, Tomoko +10 more
core +3 more sources
Autophagic receptors Nbr1 and p62 coregulate skeletal remodelling [PDF]
Autophagy, 2010 Skeletal remodeling is an ongoing process requiring the coordinated action of different cell types to maintain homeostatic control of bone synthesis and degradation. Mutations in p62/SQSTM1 are associated with sporadic and 5q35-linked Paget Disease of Bone (PDB), characterized by focal increased bone turnover.
Waters, Sarah +3 more
openaire +3 more sources
HIPK2 Is Required for Midbody Remnant Removal Through Autophagy-Mediated Degradation
Frontiers in Cell and Developmental Biology, 2020 At the end of abscission, the residual midbody forms the so-called midbody remnant (MBR), a platform affecting cell fate with emerging key role in differentiation, development, and tumorigenicity.
Francesca Sardina +6 more
doaj +1 more source
Advanced Science, 2023 Tumor‐associated macrophage (TAM) infiltration facilitates glioma malignancy, but the underlying mechanisms remain unclear. Herein, it is reported that TAMs secrete exosomal LINC01232 to induce tumor immune escape.
Junjun Li +17 more
doaj +1 more source