Results 1 to 10 of about 4,755 (111)

SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance

Cell Reports, 2021
Summary: Phosphoinositides are important molecules in lipid signaling, membrane identity, and trafficking that are spatiotemporally controlled by factors from both mammalian cells and intracellular pathogens.
Daniel B Graham, Kimberly L Carey, Ramnik J Xavier   +2 more
exaly   +3 more sources

Xenophagy as a Strategy for Mycobacterium leprae Elimination during Type 1 or Type 2 Leprosy Reactions: A Systematic Review [PDF]

Pathogens, 2023
Background: Mycobacterium leprae is an intracellular bacillus that causes leprosy, a neglected disease that affects macrophages and Schwann cells. Leprosy reactions are acute inflammatory responses to mycobacterial antigens, classified as type1 (T1R), a ...
Débora Dantas Nucci Cerqueira, Ana Letícia Silva Pereira, Ana Elisa Coelho da Costa, Tarcísio Joaquim de Souza, Matheus Santos de Sousa Fernandes, Fabrício Oliveira Souto, Patrícia d’Emery Alves Santos   +6 more
doaj   +2 more sources

Post-translational weapons of microbial warfare: how bacterial effectors hijack host cell death and xenophagy [PDF]

Cell Communication and Signaling
The intricate interplay between pathogenic bacteria and host cellular processes represents a dynamic molecular battlefield during infection. Mammalian hosts employ two critical cell-autonomous defense mechanisms, regulated cell death (RCD) and xenophagy,
Kun Meng, Liuliu Shi, Xianglan Fang, Jin Yang, Yan Ding, Zheng Cao, Shan Li   +6 more
doaj   +2 more sources

Individual Atg8 paralogs and a bacterial metabolite sequentially promote hierarchical CASM-xenophagy induction and transition

Cell Reports
Summary: Atg8 paralogs, consisting of LC3A/B/C and GBRP/GBRPL1/GATE16, function in canonical autophagy; however, their function is controversial because of functional redundancy. In innate immunity, xenophagy and non-canonical single membranous autophagy
Chisato Sakuma, Sayaka Shizukuishi, Michinaga Ogawa   +2 more
exaly   +3 more sources

An Update on the Study of the Molecular Mechanisms Involved in Autophagy during Bacterial Pathogenesis [PDF]

Biomedicines
Autophagy is a unique catabolic process that degrades irrelevant or damaged components in eukaryotic cells to maintain homeostasis and eliminate infections from pathogenesis.
Md Ataur Rahman, Amily Sarker, Mohammed Ayaz, Ananya Rahman Shatabdy, Nabila Haque, Maroua Jalouli, MD. Hasanur Rahman, Taslin Jahan Mou, Shuvra Kanti Dey, Ehsanul Hoque Apu, Muhammad Sohail Zafar, Md. Anowar Khasru Parvez   +11 more
doaj   +2 more sources

The battle between bacterial infection and autophagy in aquatic animals [PDF]

Frontiers in Immunology
Autophagy is a conserved cellular degradative pathway that has been demonstrated to play a crucial role in the innate immune response to combat infection with a range of pathogenic bacteria via xenophagy.
Qi Wang, He Xu, Jiaxue Jin, Yankai Yang, Lothar Jänsch, Senlin Li   +5 more
doaj   +2 more sources

Common Traits Spark the Mitophagy/Xenophagy Interplay

Frontiers in Physiology, 2018
Selective autophagy contributes to the wellbeing of eukaryotic cells by recycling cellular components, disposing damaged organelles, and removing pathogens, amongst others. Both the quality control process of selective mitochondrial autophagy (Mitophagy)
Aarti Singh, Sharon L Kendall, Michelangelo Campanella   +2 more
exaly   +3 more sources

Editorial: Xenophagy: Its role in pathogen infections

Frontiers in Cellular and Infection Microbiology, 2022
Yongxia Liu, Wentao Li, Zhao Xiaona
exaly   +3 more sources

The versatile defender: exploring the multifaceted role of p62 in intracellular bacterial infection

Frontiers in Cellular and Infection Microbiology, 2023
As a highly conserved, multifunctional protein with multiple domains, p62/SQSTM1 plays a crucial role in several essential cellular activities, particularly selective autophagy.
Yuhao Zhou, Yuhao Zhou, Shucheng Hua, Shucheng Hua, Lei Song, Lei Song   +5 more
doaj   +1 more source

VEGF (vascular endothelial growth factor) provides antimicrobial effects via autophagy and lysosomal empowerment in endothelial cells

Autophagy Reports, 2022
Xenophagy is an intracellular defense mechanism against invading pathogens. Streptococcus pyogenes (group A Streptococcus, GAS) is efficiently eliminated by this process in epithelial cells.
Shiou-Ling Lu, Takeshi Noda
doaj   +1 more source