Results 1 to 10 of about 5,031 (110)
Cell Reports, 2021 Summary: Phosphoinositides are important molecules in lipid signaling, membrane identity, and trafficking that are spatiotemporally controlled by factors from both mammalian cells and intracellular pathogens.
Ramnik Xavier, Daniel Graham
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Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy
Frontiers in Immunology, 2021 Nuclear dot protein 52 kDa (NDP52, also known as CALCOCO2) functions as a selective autophagy receptor. The linear ubiquitin chain assembly complex (LUBAC) specifically generates the N-terminal Met1-linked linear ubiquitin chain, and regulates innate ...
Seigo Terawaki +2 more
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Post-translational weapons of microbial warfare: how bacterial effectors hijack host cell death and xenophagy [PDF]
Cell Communication and SignalingThe intricate interplay between pathogenic bacteria and host cellular processes represents a dynamic molecular battlefield during infection. Mammalian hosts employ two critical cell-autonomous defense mechanisms, regulated cell death (RCD) and xenophagy,
Kun Meng +6 more
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Common Traits Spark the Mitophagy/Xenophagy Interplay
Frontiers in Physiology, 2018 Selective autophagy contributes to the wellbeing of eukaryotic cells by recycling cellular components, disposing damaged organelles, and removing pathogens, amongst others. Both the quality control process of selective mitochondrial autophagy (Mitophagy)
Michelangelo Campanella +1 more
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The battle between bacterial infection and autophagy in aquatic animals [PDF]
Frontiers in ImmunologyAutophagy is a conserved cellular degradative pathway that has been demonstrated to play a crucial role in the innate immune response to combat infection with a range of pathogenic bacteria via xenophagy.
Qi Wang +5 more
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Selective Autophagy and Xenophagy in Infection and Disease
Frontiers in Cell and Developmental Biology, 2018 Autophagy, a cellular homeostatic process, which ensures cellular survival under various stress conditions, has catapulted to the forefront of innate defense mechanisms during intracellular infections.
Dhiraj Kumar +2 more
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CellsAutophagy engulfs cellular components in double-membrane-bound autophagosomes for clearance and recycling after fusion with lysosomes. Thus, autophagy is a key process for maintaining proteostasis and a powerful cell-intrinsic host defense mechanism ...
Bustamante H A +2 more
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Unc-51-like kinase 1 (ULK1) regulates bacterial ubiquitylation and p62 recruitment during xenophagic clearance of Listeria monocytogenes [PDF]
mSphereAutophagy is an essential cellular homeostatic process that also serves as an innate immune mechanism against intracellular bacterial pathogens through a highly selective form of autophagy known as xenophagy.
J. S. Ribeiro +8 more
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Frontiers in Immunology, 2019 Autophagy is a lysosomal degradation process that contributes to host immunity by eliminating invasive pathogens and the modulating inflammatory response.
Pierre Lapaquette +2 more
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The versatile defender: exploring the multifaceted role of p62 in intracellular bacterial infection
Frontiers in Cellular and Infection Microbiology, 2023 As a highly conserved, multifunctional protein with multiple domains, p62/SQSTM1 plays a crucial role in several essential cellular activities, particularly selective autophagy.
Yuhao Zhou +5 more
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