Results 31 to 40 of about 5,446 (188)
mBio, 2022 Group A Streptococcus (GAS), a deleterious human-pathogenic bacterium, causes life-threatening diseases such as sepsis and necrotic fasciitis. We recently reported that GAS survives and replicates within blood vessel endothelial cells because these cells
Shiou-Ling Lu +6 more
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Selective autophagy: Xenophagy [PDF]
Methods, 2015 Xenophagy is an autophagic phenomenon that specifically involves pathogens and other non-host entities. Although the understanding of the relationship between autophagosomes and invading organisms has grown significantly in the past decade, the exact steps to confirm xenophagy has been not been thoroughly defined. Here we describe a methodical approach
Kyle A, Bauckman +2 more
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Xenophagy in herpes simplex virus replication and pathogenesis [PDF]
Autophagy, 2008 Autophagy functions in part as an important host defense mechanism to engulf and degrade intracellular pathogens, a process that has been termed xenophagy. Xenophagy is detrimental to the invading microbe in terms of replication and pathogenesis and many pathogens either dampen the autophagic response, or utilize the pathway to enhance their life cycle.
Alexander, Diane E, Leib, David A
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Cell Reports, 2023 Summary: Xenophagy is an evolutionarily conserved host defensive mechanism to eliminate invading microorganisms through autophagic machinery. The intracellular bacterial pathogen Legionella pneumophila can avoid clearance by the xenophagy pathway via the
Jinli Ge +6 more
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Frontiers in Pharmacology, 2021 Helicobacter pylori was classified by the World Health Organization as a class 1 carcinogen. The development of drug-resistant strains of this pathogen poses a serious threat to human health worldwide. The cell invasion of H.
Yifei Xu +12 more
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Xenophagy: Pathogen-Containing Vacuoles Are Hard to Digest [PDF]
Current Biology, 2019 Many intracellular pathogens reside in host-membrane-encased vacuoles, but the mechanism initiating xenophagic targeting of these vacuoles was unknown. A recent study identifies the host vacuolar-ATPase as essential to xenophagic clearance and the Salmonellae effector SopF that inhibits bacterial clearance by its ADP-ribosylation.
Anu, Chaudhary, Samuel I, Miller
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Rab41-mediated ESCRT machinery repairs membrane rupture by a bacterial toxin in xenophagy
Nature Communications, 2023 Xenophagy, a type of selective autophagy, is a bactericidal membrane trafficking that targets cytosolic bacterial pathogens, but the membrane homeostatic system to cope with bacterial infection in xenophagy is not known.
Takashi Nozawa +8 more
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Essential Role for the Mammalian ATG8 Isoform LC3C in Xenophagy [PDF]
Molecular Cell, 2012 In this issue, Randow and coworkers (von Muhlinen et al., 2012) report that LC3C plays an essential role in Salmonella clearance by interacting with the autophagic receptor NDP52, with consequent recruitment of all other ATG8 proteins to assist in the buildup of the autophagic membrane.
Shpilka, Tomer, Elazar, Zvulun
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LAMTOR2/LAMTOR1 complex is required for TAX1BP1‐mediated xenophagy [PDF]
Cellular Microbiology, 2019 Xenophagy, also known as antibacterial autophagy, plays a role in host defence against invading pathogens such as Group A Streptococcus (GAS) and Salmonella. In xenophagy, autophagy receptors are used in the recognition of invading pathogens and in autophagosome maturation and autolysosome formation.
Ching‐Yu Lin +5 more
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When the Phagosome Gets Leaky: Pore-Forming Toxin-Induced Non-Canonical Autophagy (PINCA)
Frontiers in Cellular and Infection Microbiology, 2022 Macrophages remove bacteria from the extracellular milieu via phagocytosis. While most of the engulfed bacteria are degraded in the antimicrobial environment of the phagolysosome, several bacterial pathogens have evolved virulence factors, which evade ...
Marc Herb +8 more
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