Results 31 to 40 of about 4,824 (164)
Evolving immunity: Xenophagy and the removal of intracellular pathogens [PDF]
The Biochemist, 2012 Early eukaryotes, such as free-living protozoa and yeasts, had to adapt to rapidly changing environments and an uncertain food supply. Lack of food imposed serious stress on these cells and it is thought that this drove the evolution of a membrane trafficking pathway called autophagy.
Zhigang Zhou +4 more
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Membrane Curvature: The Inseparable Companion of Autophagy
Cells, 2023 Autophagy is a highly conserved recycling process of eukaryotic cells that degrades protein aggregates or damaged organelles with the participation of autophagy-related proteins.
Lei Liu +12 more
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Autophagy in Viral Infection and Pathogenesis
Frontiers in Cell and Developmental Biology, 2021 As an evolutionarily conserved cellular process, autophagy plays an essential role in the cellular metabolism of eukaryotes as well as in viral infection and pathogenesis.
Shan Liang +5 more
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Eating the unknown: Xenophagy and ER-phagy are cytoprotective defenses against pathogens
Experimental Cell Research, 2020 Autophagy is an evolutionary conserved catabolic process devoted to the removal of unnecessary and harmful cellular components. In its general form, autophagy governs cellular lifecycle through the formation of double membrane vesicles, termed autophagosomes, that enwrap and deliver unwanted intracellular components to lysosomes.
Reggio, Alessio +2 more
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A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy [PDF]
Nature Communications, 2019 AbstractUbiquitin-mediated xenophagy, a type of selective autophagy, plays crucial roles in host defense against intracellular pathogens includingMycobacterium tuberculosis(Mtb). However, the exact mechanism by which host ubiquitin targets invaded microbes to trigger xenophagy remains obscure.
Qiyao Chai +15 more
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How bacteria can block xenophagy: an insight from Salmonella [PDF]
Autophagy, 2019 Xenophagy, a unique type of selective macroautophagy/autophagy, targets invading pathogens as part of the host immune response. In order to survive within the host, bacteria have established various self-defense mechanisms. In a recent paper from Feng Shao's lab, the Salmonella effector protein SopF has been demonstrated to block xenophagy by ...
Xin Wen, Daniel J. Klionsky
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Journal of Pure and Applied Microbiology, 2018 The complex interplay between H. pylori and autophagy was elucidated in gastritis in term of host defense and survival of microbe. However, H. pylori frequently succeed in their survival and develops more aggressive tissue damage by different ways.
Haider F. Ghazi +3 more
doaj +1 more source
eLife, 2020 The selective autophagy pathways of xenophagy and mitophagy are initiated when the adaptor NDP52 recruits the ULK1 complex to autophagic cargo. Hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS) was used to map the membrane and NDP52 ...
Xiaoshan Shi +4 more
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Anaplasmataceae: Dichotomous Autophagic Interplay for Infection
Frontiers in Immunology, 2021 Autophagy is a vital conserved degradative process that maintains cellular homeostasis by recycling or eliminating dysfunctional cellular organelles and proteins.
LaNisha L. Patterson +6 more
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Matrine activates high xenophagy to inhibit enterovirus replication
PhytomedicineEnteroviruses continue to pose a significant public health threat due to the morbidity and mortality associated with a shortage of targeted drugs and the limited availability of existing vaccines. This underscores the need to explore effective antiviral agents.This study examined the antiviral potential of matrine, an alkaloid extracted from Sophora ...
Xinhua Li +14 more
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