Results 11 to 20 of about 4,824 (164)
Endothelial cells are intrinsically defective in xenophagy of Streptococcus pyogenes. [PDF]
PLoS Pathogens, 2017 Group A Streptococcus (GAS) is deleterious pathogenic bacteria whose interaction with blood vessels leads to life-threatening bacteremia. Although xenophagy, a special form of autophagy, eliminates invading GAS in epithelial cells, we found that GAS ...
Shiou-Ling Lu +10 more
doaj +4 more sources
Survival of intracellular pathogens in response to mTORC1- or TRPML1-TFEB-induced xenophagy
Autophagy Reports, 2023 Intracellular pathogens establish persistent infections by generating reservoirs that protect them from the action of antibiotics and the host immune response.
Mariana I. Capurro +3 more
doaj +3 more sources
Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy [PDF]
Frontiers in Immunology, 2021 Nuclear dot protein 52 kDa (NDP52, also known as CALCOCO2) functions as a selective autophagy receptor. The linear ubiquitin chain assembly complex (LUBAC) specifically generates the N-terminal Met1-linked linear ubiquitin chain, and regulates innate ...
Hirohisa Miyashita +5 more
doaj +3 more sources
Selective Autophagy and Xenophagy in Infection and Disease [PDF]
Frontiers in Cell and Developmental Biology, 2018 Autophagy, a cellular homeostatic process, which ensures cellular survival under various stress conditions, has catapulted to the forefront of innate defense mechanisms during intracellular infections.
Vartika Sharma +4 more
doaj +3 more sources
Handcuffs for bacteria - NDP52 orchestrates xenophagy of intracellular Salmonella [PDF]
Microbial Cell, 2015 Eukaryotic cells can selectively target and degrade intracellular pathogens using autophagy, a process referred to as xenophagy. This selectivity is controlled by proteins called autophagy receptors, which can recognise pathogens and address ...
Pauline Verlhac +2 more
doaj +4 more sources
Selective autophagy: Xenophagy [PDF]
Methods, 2015 Xenophagy is an autophagic phenomenon that specifically involves pathogens and other non-host entities. Although the understanding of the relationship between autophagosomes and invading organisms has grown significantly in the past decade, the exact steps to confirm xenophagy has been not been thoroughly defined. Here we describe a methodical approach
Kyle A, Bauckman +2 more
openaire +2 more sources
mBio, 2022 Group A Streptococcus (GAS), a deleterious human-pathogenic bacterium, causes life-threatening diseases such as sepsis and necrotic fasciitis. We recently reported that GAS survives and replicates within blood vessel endothelial cells because these cells
Shiou-Ling Lu +6 more
doaj +1 more source
Xenophagy in herpes simplex virus replication and pathogenesis [PDF]
Autophagy, 2008 Autophagy functions in part as an important host defense mechanism to engulf and degrade intracellular pathogens, a process that has been termed xenophagy. Xenophagy is detrimental to the invading microbe in terms of replication and pathogenesis and many pathogens either dampen the autophagic response, or utilize the pathway to enhance their life cycle.
Alexander, Diane E, Leib, David A
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Dual function of CALCOCO2/NDP52 during xenophagy [PDF]
Autophagy, 2015 During xenophagy, pathogens are selectively targeted by autophagy receptors to the autophagy machinery for their subsequent degradation. In infected cells, the autophagy receptor CALCOCO2/NDP52 targets Salmonella Typhimurium to the phagophore membrane by concomitantly interacting with LC3C and binding to ubiquitinated cytosolic bacteria or to LGALS8 ...
Verlhac, Pauline +2 more
openaire +4 more sources
Xenophagy: Pathogen-Containing Vacuoles Are Hard to Digest [PDF]
Current Biology, 2019 Many intracellular pathogens reside in host-membrane-encased vacuoles, but the mechanism initiating xenophagic targeting of these vacuoles was unknown. A recent study identifies the host vacuolar-ATPase as essential to xenophagic clearance and the Salmonellae effector SopF that inhibits bacterial clearance by its ADP-ribosylation.
Anu, Chaudhary, Samuel I, Miller
openaire +2 more sources