Results 11 to 20 of about 5,446 (188)

Endothelial cells are intrinsically defective in xenophagy of Streptococcus pyogenes. [PDF]

PLoS Pathogens, 2017
Group A Streptococcus (GAS) is deleterious pathogenic bacteria whose interaction with blood vessels leads to life-threatening bacteremia. Although xenophagy, a special form of autophagy, eliminates invading GAS in epithelial cells, we found that GAS ...
Shiou-Ling Lu, Tsuyoshi Kawabata, Yi-Lin Cheng, Hiroko Omori, Maho Hamasaki, Tatsuya Kusaba, Ryo Iwamoto, Hirokazu Arimoto, Takeshi Noda, Yee-Shin Lin, Tamotsu Yoshimori   +10 more
doaj   +5 more sources

Survival of intracellular pathogens in response to mTORC1- or TRPML1-TFEB-induced xenophagy

Autophagy Reports, 2023
Intracellular pathogens establish persistent infections by generating reservoirs that protect them from the action of antibiotics and the host immune response.
Mariana I. Capurro, Akriti Prashar, Xiaodong Gao, Nicola L. Jones   +3 more
doaj   +4 more sources

Dual function of CALCOCO2/NDP52 during xenophagy [PDF]

Autophagy, 2015
International audienceDuring xenophagy, pathogens are selectively targeted by autophagy receptors to the autophagy machinery for their subsequent degradation.
Verlhac, Pauline, Viret, Christophe, Faure, Mathias   +2 more
core   +5 more sources

Handcuffs for bacteria - NDP52 orchestrates xenophagy of intracellular Salmonella [PDF]

Microbial Cell, 2015
Eukaryotic cells can selectively target and degrade intracellular pathogens using autophagy, a process referred to as xenophagy. This selectivity is controlled by proteins called autophagy receptors, which can recognise pathogens and address ...
Pauline Verlhac, Mathias Faure, Christophe Viret, Verlhac, Pauline, Viret, Christophe, Faure, Mathias   +5 more
core   +6 more sources

NBR1-mediated antiviral xenophagy in plant immunity [PDF]

Autophagy, 2017
Macroautophagy/autophagy intersects with metazoan virus infections in highly complex and multifaceted ways. Autophagy mechanisms are part of antiviral immunity, but can be manipulated by several viruses to the benefit of infection.
Sveriges lantbruksuniversitet., Hafrén, Anders,, Hofius, Daniel,   +2 more
core   +3 more sources

Xenophagy as a Strategy for Mycobacterium leprae Elimination during Type 1 or Type 2 Leprosy Reactions: A Systematic Review

Pathogens, 2023
Background: Mycobacterium leprae is an intracellular bacillus that causes leprosy, a neglected disease that affects macrophages and Schwann cells. Leprosy reactions are acute inflammatory responses to mycobacterial antigens, classified as type1 (T1R), a ...
Débora Dantas Nucci Cerqueira, Ana Letícia Silva Pereira, Ana Elisa Coelho da Costa, Tarcísio Joaquim de Souza, Matheus Santos de Sousa Fernandes, Fabrício Oliveira Souto, Patrícia d’Emery Alves Santos   +6 more
doaj   +2 more sources

Immunohistochemical Expression of Xenophagy Proteins in Helicobacter pylori and None Helicobacter pylori Gastritis

Journal of Pure and Applied Microbiology, 2018
The complex interplay between H. pylori and autophagy was elucidated in gastritis in term of host defense and survival of microbe. However, H. pylori frequently succeed in their survival and develops more aggressive tissue damage by different ways.
Haider F. Ghazi, Hayfaa M. Fahad, Aqeel S. Mahmood, Ban J. Qasim   +3 more
doaj   +2 more sources

Restricting intracellular <i>Salmonella</i> proliferation by coordinating p-TBK1 mediated mitophagy and xenophagy. [PDF]

Autophagy
Mitophagy is essential for eliminating dysfunctional mitochondria and is closely implicated in the immune evasion of several pathogens, including S. typhimurium. However, the specific mechanisms regarding the interaction between S.
Li J, Yang Y, Ge Y, Zhang X, Liu H, Chen Y, Yang Y, Wu Z.   +7 more
europepmc   +4 more sources

The E3 ubiquitin ligase SIAH1 targets a bacterial pore-forming toxin to facilitate xenophagy

Cell Reports
Summary: Xenophagy, one form of selective autophagy, recognizes and eliminates the invading pathogen through the ubiquitination of bacterial surface components.
Min Wu, Xin Hu, Junpei Iibushi, Kazunori Murase, Takashi Nozawa, Ichiro Nakagawa   +5 more
doaj   +2 more sources

Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy [PDF]

FEBS Letters, 2014
Upon infection of a cell by Salmonella, p62/Sqstm1 assembles on the microbes; simultaneously, p62/Sqstm1 is phosphorylated at Ser351, leading to inactivation of Keap1, which is responsible for degrading Nrf2. Thus, cytoprotective Nrf2 targets are induced
Tanaka, Keiji, Ishimura, Ryosuke, Komatsu, Masaaki   +2 more
core   +4 more sources