Results 21 to 30 of about 4,824 (164)
Frontiers in Pharmacology, 2021 Helicobacter pylori was classified by the World Health Organization as a class 1 carcinogen. The development of drug-resistant strains of this pathogen poses a serious threat to human health worldwide. The cell invasion of H.
Yifei Xu +12 more
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NBR1-mediated antiviral xenophagy in plant immunity [PDF]
Autophagy, 2017 Macroautophagy/autophagy intersects with metazoan virus infections in highly complex and multifaceted ways. Autophagy mechanisms are part of antiviral immunity, but can be manipulated by several viruses to the benefit of infection. In plants, however, the roles of autophagy in virus infections have only recently started to emerge.
Anders, Hafrén, Daniel, Hofius
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Cell Reports, 2023 Summary: Xenophagy is an evolutionarily conserved host defensive mechanism to eliminate invading microorganisms through autophagic machinery. The intracellular bacterial pathogen Legionella pneumophila can avoid clearance by the xenophagy pathway via the
Jinli Ge +6 more
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Rab41-mediated ESCRT machinery repairs membrane rupture by a bacterial toxin in xenophagy
Nature Communications, 2023 Xenophagy, a type of selective autophagy, is a bactericidal membrane trafficking that targets cytosolic bacterial pathogens, but the membrane homeostatic system to cope with bacterial infection in xenophagy is not known.
Takashi Nozawa +8 more
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LAMTOR2/LAMTOR1 complex is required for TAX1BP1‐mediated xenophagy [PDF]
Cellular Microbiology, 2019 Xenophagy, also known as antibacterial autophagy, plays a role in host defence against invading pathogens such as Group A Streptococcus (GAS) and Salmonella. In xenophagy, autophagy receptors are used in the recognition of invading pathogens and in autophagosome maturation and autolysosome formation.
Ching‐Yu Lin +5 more
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Essential Role for the Mammalian ATG8 Isoform LC3C in Xenophagy [PDF]
Molecular Cell, 2012 In this issue, Randow and coworkers (von Muhlinen et al., 2012) report that LC3C plays an essential role in Salmonella clearance by interacting with the autophagic receptor NDP52, with consequent recruitment of all other ATG8 proteins to assist in the buildup of the autophagic membrane.
Shpilka, Tomer, Elazar, Zvulun
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When the Phagosome Gets Leaky: Pore-Forming Toxin-Induced Non-Canonical Autophagy (PINCA)
Frontiers in Cellular and Infection Microbiology, 2022 Macrophages remove bacteria from the extracellular milieu via phagocytosis. While most of the engulfed bacteria are degraded in the antimicrobial environment of the phagolysosome, several bacterial pathogens have evolved virulence factors, which evade ...
Marc Herb +8 more
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FEBS Open Bio, 2018 Autophagy is a bulk degradation pathway, and selective autophagy to remove foreign entities is called xenophagy. The conjugation of ubiquitin to target pathogens is an important process in xenophagy but when and where this ubiquitination occurs remains ...
Megumi Tsuchiya +7 more
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In Silico Knockout Studies of Xenophagic Capturing of Salmonella.
PLoS Computational Biology, 2016 The degradation of cytosol-invading pathogens by autophagy, a process known as xenophagy, is an important mechanism of the innate immune system.
Jennifer Scheidel +4 more
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Autophagy controls Wolbachia infection upon bacterial damage and in aging Drosophila
Frontiers in Cell and Developmental Biology, 2022 Autophagy is a conserved catabolic process in eukaryotic cells that degrades intracellular components in lysosomes, often in an organelle-specific selective manner (mitophagy, ERphagy, etc).
Dávid Hargitai +6 more
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