Results 21 to 30 of about 5,446 (188)

Eating the unknown: Xenophagy and ER-phagy are cytoprotective defenses against pathogens

Experimental Cell Research, 2020
Autophagy is an evolutionary conserved catabolic process devoted to the removal of unnecessary and harmful cellular components. In its general form, autophagy governs cellular lifecycle through the formation of double membrane vesicles, termed ...
Alessio Reggio, Viviana Buonomo, Grumati, Paolo, Paolo Grumati, Buonomo, Viviana, Reggio, Alessio   +5 more
core   +4 more sources

Vaccinia virus subverts xenophagy through phosphorylation and nuclear targeting of p62 [PDF]

, 2021
Autophagy is an essential degradation program required to maintain cell homeostasis. Amongst its many functions is the engulfment and destruction of cytosolic pathogens, termed Xenophagy.
Mercer, Jason, Kriston-Vizi, Janos, Krause, Melanie, Huttunen, Moona, Yakimovich, Artur   +4 more
core   +2 more sources

An Update on the Study of the Molecular Mechanisms Involved in Autophagy during Bacterial Pathogenesis

Biomedicines
Autophagy is a unique catabolic process that degrades irrelevant or damaged components in eukaryotic cells to maintain homeostasis and eliminate infections from pathogenesis.
Md Ataur Rahman, Amily Sarker, Mohammed Ayaz, Ananya Rahman Shatabdy, Nabila Haque, Maroua Jalouli, MD. Hasanur Rahman, Taslin Jahan Mou, Shuvra Kanti Dey, Ehsanul Hoque Apu, Muhammad Sohail Zafar, Md. Anowar Khasru Parvez   +11 more
doaj   +2 more sources

Restriction of intracellular Salmonella replication by restoring TFEB-mediated xenophagy

Autophagy, 2019
Macroautophagy/autophagy functions as a part of the innate immune system in clearing intracellular pathogens. Although this process is well known, the mechanisms that control antibacterial autophagy are not clear.
Veena Ammanathan (5074160), Ravi Manjithaya (3872647), Sasikumar Muthusamy (7890764), Vidya Jadhav (7890767), Aravinda K. Chavalmane (3872644), Piyush Mishra (773745), Chandrashekaran Siddamadappa (7890770)   +6 more
core   +4 more sources

Vaccinia virus subverts xenophagy through phosphorylation and nuclear targeting of p62 [PDF]

Journal of Cell Biology
Autophagy is an essential degradation program required for cell homeostasis. Among its functions is the engulfment and destruction of cytosolic pathogens, termed xenophagy.
Mercer, Jason, Kriston-Vizi, Janos, Frickel, Eva-Maria, Samolej, Jerzy, Krause, Melanie, Huttunen, Moona, Lara-Reyna, Samuel, Yakimovich, Artur   +7 more
core   +6 more sources

Editorial: Xenophagy: Its role in pathogen infections

Frontiers in Cellular and Infection Microbiology, 2022
Xiaona Zhao, Yongxia Liu, Hongwei Wang, Wentao Li, Jianzhu Liu   +4 more
doaj   +3 more sources

Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy

mBio, 2019
Group A streptococcus (GAS) is an important human pathogen which can cause fatal diseases after invasion into the bloodstream. Although antibiotics and immune surveillance are the main defenses against GAS infection, GAS utilizes internalization into ...
Yi-Lin Cheng, Chih-Feng Kuo, Shiou-Ling Lu, Hiroko Omori, Ya-Na Wu, Cheng-Lu Hsieh, Takeshi Noda, Shang-Rung Wu, Robert Anderson, Chiou-Feng Lin, Chia-Ling Chen, Jiunn-Jong Wu, Yee-Shin Lin   +12 more
doaj   +2 more sources

Xenophagy

British Dental Journal, 1981
E Samson
core   +3 more sources

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy. [PDF]

Adv Sci (Weinh)
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Lin Y, Dai M, Dai E, Kang R, Klionsky DJ, Tang D, Sun Y, Lv N, Jiang J.   +8 more
europepmc   +2 more sources

VEGF (vascular endothelial growth factor) provides antimicrobial effects via autophagy and lysosomal empowerment in endothelial cells

Autophagy Reports, 2022
Xenophagy is an intracellular defense mechanism against invading pathogens. Streptococcus pyogenes (group A Streptococcus, GAS) is efficiently eliminated by this process in epithelial cells.
Shiou-Ling Lu, Takeshi Noda
doaj   +1 more source