Results 41 to 50 of about 5,446 (188)
Evolving immunity: Xenophagy and the removal of intracellular pathogens [PDF]
The Biochemist, 2012 Early eukaryotes, such as free-living protozoa and yeasts, had to adapt to rapidly changing environments and an uncertain food supply. Lack of food imposed serious stress on these cells and it is thought that this drove the evolution of a membrane trafficking pathway called autophagy.
Zhigang Zhou +4 more
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FEBS Open Bio, 2018 Autophagy is a bulk degradation pathway, and selective autophagy to remove foreign entities is called xenophagy. The conjugation of ubiquitin to target pathogens is an important process in xenophagy but when and where this ubiquitination occurs remains ...
Megumi Tsuchiya +7 more
doaj +1 more source
In Silico Knockout Studies of Xenophagic Capturing of Salmonella.
PLoS Computational Biology, 2016 The degradation of cytosol-invading pathogens by autophagy, a process known as xenophagy, is an important mechanism of the innate immune system.
Jennifer Scheidel +4 more
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, 2021 Mitochondrial function and innate immunity are intimately linked; however, the mechanisms how mitochondrion-shaping proteins regulate innate host defense remains largely unknown.
Silwal, Prashanta +21 more
core +1 more source
Autophagy controls Wolbachia infection upon bacterial damage and in aging Drosophila
Frontiers in Cell and Developmental Biology, 2022 Autophagy is a conserved catabolic process in eukaryotic cells that degrades intracellular components in lysosomes, often in an organelle-specific selective manner (mitophagy, ERphagy, etc).
Dávid Hargitai +6 more
doaj +1 more source
Membrane Curvature: The Inseparable Companion of Autophagy
Cells, 2023 Autophagy is a highly conserved recycling process of eukaryotic cells that degrades protein aggregates or damaged organelles with the participation of autophagy-related proteins.
Lei Liu +12 more
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Autophagy in Viral Infection and Pathogenesis
Frontiers in Cell and Developmental Biology, 2021 As an evolutionarily conserved cellular process, autophagy plays an essential role in the cellular metabolism of eukaryotes as well as in viral infection and pathogenesis.
Shan Liang +5 more
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A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy [PDF]
Nature Communications, 2019 AbstractUbiquitin-mediated xenophagy, a type of selective autophagy, plays crucial roles in host defense against intracellular pathogens includingMycobacterium tuberculosis(Mtb). However, the exact mechanism by which host ubiquitin targets invaded microbes to trigger xenophagy remains obscure.
Qiyao Chai +15 more
openaire +3 more sources
Cell ReportsSummary: Atg8 paralogs, consisting of LC3A/B/C and GBRP/GBRPL1/GATE16, function in canonical autophagy; however, their function is controversial because of functional redundancy. In innate immunity, xenophagy and non-canonical single membranous autophagy
Chisato Sakuma +10 more
doaj +1 more source
eLife, 2020 The selective autophagy pathways of xenophagy and mitophagy are initiated when the adaptor NDP52 recruits the ULK1 complex to autophagic cargo. Hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS) was used to map the membrane and NDP52 ...
Xiaoshan Shi +4 more
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