Results 51 to 60 of about 4,824 (164)

Interplay between septins and ubiquitin-mediated xenophagy during Shigella entrapment

Autophagy Reports, 2023
Septins are cytoskeletal proteins implicated in numerous cellular processes including cytokinesis and morphogenesis. In the case of infection by Shigella flexneri, septins assemble into cage-like structures that entrap cytosolic bacteria targeted by autophagy. The interplay between septin cage entrapment and bacterial autophagy is poorly understood. We
Damián Lobato-Márquez, José Javier Conesa, Ana Teresa López-Jiménez, Michael E. Divine, Jonathan N. Pruneda, Serge Mostowy   +5 more
openaire   +3 more sources

Xenophagy and Beyond: A Narrative Review on Canonical and Noncanonical Autophagy in Host Defense Against Bacterial Pathogens

Infectious Microbes & Diseases
Autophagy is a fundamental cellular process that maintains homeostasis and defends against intracellular pathogens. In particular, xenophagy, a specialized form of autophagy, plays a pivotal role in the innate immune response by targeting and eliminating
Shuai Gao, Dailin Yuan, Stijn van der Veen   +2 more
doaj   +1 more source

HEATR3 recognizes membrane rupture and facilitates xenophagy in response to <i>Salmonella</i> invasion. [PDF]

Proc Natl Acad Sci U S A
Bacterial invasion into the cytoplasm of epithelial cells triggers the activation of the cellular autophagic machinery as a defense mechanism, a process known as xenophagy. In this study, we identified HEATR3, an LC3-interacting region (LIR)-containing protein, as a factor involved in this defense mechanism using quantitative mass ...
Arakawa M, Uriu K, Saito K, Hirose M, Katoh K, Asano K, Nakane A, Saitoh T, Yoshimori T, Morita E.   +9 more
europepmc   +4 more sources

Immune activation and response dynamics of human iPSC‐derived macrophages in tuberculosis infection models

Clinical &Translational Immunology, Volume 15, Issue 1, 2026.
In this study, we analysed the immune responses of blood‐derived monocyte macrophages and iPSC‐derived macrophages following BCG/HKMT infection. We found that iPSC‐derived macrophages displayed a markedly stronger activation profile, including faster migration, increased reactive oxygen species production, elevated apoptosis marker expression and ...
Daniela Paasch, Hannah Schevel, Andrea Riehle, Bibiana Costa, Hassan Toufaili, Tabea Gehnen, Julia Dahlmann, Andreas Pavlou, Anna‐Lena Neehus, Ariane Hai Ha Nguyen, Erika Schiering, Theresa Buchegger, Jacinta Bustamante, Gesine Hansen, Ulrich Kalinke, Erich Gulbins, Heike Grassmé, Nico Lachmann   +17 more
wiley   +1 more source

Ubiquilin 1 Promotes IFN-γ-Induced Xenophagy of Mycobacterium tuberculosis

PLOS Pathogens, 2015
The success of Mycobacterium tuberculosis (Mtb) as a pathogen rests upon its ability to grow intracellularly in macrophages. Interferon-gamma (IFN-γ) is critical in host defense against Mtb and stimulates macrophage clearance of Mtb through an autophagy pathway.
Erik T Sakowski, Stefan Koster, Cynthia Portal Celhay, Heidi S Park, Elina Shrestha, Stefanie E Hetzenecker, Katie Maurer, Ken Cadwell, Jennifer A Philips   +8 more
openaire   +3 more sources

Autophagy in Crohn’s Disease: Converging on Dysfunctional Innate Immunity

Cells, 2023
Crohn’s disease (CD) is a chronic inflammatory bowel disease marked by relapsing, transmural intestinal inflammation driven by innate and adaptive immune responses.
Kibrom M. Alula, Arianne L. Theiss
doaj   +1 more source

Multiomics Integration Reveals Genetic, Metabolic, and Microbial Signatures of Crohn′s Disease

Human Mutation, Volume 2026, Issue 1, 2026.
Crohn′s disease (CD) is a complex inflammatory bowel disorder with multifactorial etiology involving genetic susceptibility, metabolic dysregulation, and intestinal microbiome alterations. Although individual omics studies have provided insights into CD pathogenesis, integrative analyses linking these molecular layers remain limited. Here, we performed
Xianguo Qu, Rui Wang, Jingmiao Chen, Yue Gao, Bei Li, Hao Chi   +5 more
wiley   +1 more source

Avian Pathogenic Escherichia coli T6SS Effector Protein Hcp2 Induces Mitochondrial Dysfunction and Activates Mitophagy in Chicken Tracheal Mucosal Epithelial Cells

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
The secretion system of avian pathogenic Escherichia coli (APEC) plays a key role in bacterial colonization and invasion of the host. The core structural component of the type VI secretion system (T6SS), hemolysin‐coregulatory protein (Hcp), functions both as a T6SS structural component and a secreted virulence effector.
Bingyu Zhao, Ziqi Li, Liyang Dai, Yifei Huang, Yaqin Tian, Xiyang Wei, Chenchen Sheng, Zhenyu Wang, Ying Shao, Jiumeng Sun, Jian Tu, Xiangjun Song, Zhong Peng   +12 more
wiley   +1 more source

A Structural View of Xenophagy, a Battle between Host and Microbes.

Molecules and cells, 2018
The cytoplasm in mammalian cells is a battlefield between the host and invading microbes. Both the living organisms have evolved unique strategies for their survival. The host utilizes a specialized autophagy system, xenophagy, for the clearance of invading pathogens, whereas bacteria secrete proteins to defend and escape from the host xenophagy ...
Kwon, Do Hoon, Song, Hyun Kyu
openaire   +2 more sources

Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages

mBio, 2021
Mycobacterium tuberculosis (Mtb) causes one of the deadliest infectious diseases worldwide. Upon infection, Mtb is phagocytosed by macrophages and uses its virulence-associated ESX-1 secretion system to modulate the host cell.
Samantha L. Bell, Kayla L. Lopez, Jeffery S. Cox, Kristin L. Patrick, Robert O. Watson   +4 more
doaj   +1 more source