Results 51 to 60 of about 5,446 (188)

Anaplasmataceae: Dichotomous Autophagic Interplay for Infection

Frontiers in Immunology, 2021
Autophagy is a vital conserved degradative process that maintains cellular homeostasis by recycling or eliminating dysfunctional cellular organelles and proteins.
LaNisha L. Patterson, Caitlan D. Byerly, Jere W. McBride, Jere W. McBride, Jere W. McBride, Jere W. McBride, Jere W. McBride   +6 more
doaj   +1 more source

Xenophagy receptors Optn and p62 and autophagy modulator Dram1 independently promote the zebrafish host defense against Mycobacterium marinum

Frontiers in Cellular and Infection Microbiology
Anti-bacterial autophagy, also known as xenophagy, is a crucial innate immune process that helps maintain cellular homeostasis by targeting invading microbes.
Jiajun Xie, Annemarie H. Meijer
doaj   +1 more source

The Role of Autophagy in Crohn’s Disease

Cells, 2012
(Macro)-autophagy is a homeostatic process by which eukaryotic cells dispose of protein aggregates and damaged organelles. Autophagy is also used to degrade micro-organisms that invade intracellularly in a process termed xenophagy.
Craig Stevens, Paul Henderson
doaj   +1 more source

Advances in research on autophagy in the maintenance of insect–microbe symbiosis

New Plant Protection, EarlyView.
Autophagy plays a dual regulatory role in insect–microbe symbiotic relationships. Beneficial symbiotic bacteria in insects participate in nutrient exchange via the TOR pathway, whereas pathogenic microbes induce immune defense through the AMPK pathway. Autophagy‐related genes regulate development and pathogen clearance during this process.
Yanbin Wang, Yuqiong Hao, Ke Chen, Hongbin Zhang, Xiansheng Xie, Feirong Ren   +5 more
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Matrine activates high xenophagy to inhibit enterovirus replication

Phytomedicine
Enteroviruses continue to pose a significant public health threat due to the morbidity and mortality associated with a shortage of targeted drugs and the limited availability of existing vaccines. This underscores the need to explore effective antiviral agents.This study examined the antiviral potential of matrine, an alkaloid extracted from Sophora ...
Xinhua Li, Yue Liu, Xiaoyan Yu, Xue Guan, Siyu Liu, Wenbo Huo, Xinhe Zhou, Minna Cui, Mengyu Liu, Cong Wang, Changrui Huang, Hongying Bai, Siyi Yin, Shijiao Bai, Jinghua Yu   +14 more
openaire   +3 more sources

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

How bacteria can block xenophagy: an insight from Salmonella [PDF]

Autophagy, 2019
Xenophagy, a unique type of selective macroautophagy/autophagy, targets invading pathogens as part of the host immune response. In order to survive within the host, bacteria have established various self-defense mechanisms. In a recent paper from Feng Shao's lab, the Salmonella effector protein SopF has been demonstrated to block xenophagy by ...
Xin Wen, Daniel J. Klionsky
openaire   +2 more sources

TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling.

PLoS ONE, 2012
K-Ras dependent non-small cell lung cancer (NSCLC) cells are 'addicted' to basal autophagy that reprograms cellular metabolism in a lysosomal-sensitive manner.
Alice C Newman, Caroline L Scholefield, Alain J Kemp, Michelle Newman, Edward G McIver, Ahmad Kamal, Simon Wilkinson   +6 more
doaj   +1 more source

The gut microbiome organ

iMeta, Volume 5, Issue 4, August 2026.
The gut microbiome can be conceptualized as a distributed organ‐like functional system with spatially structured organization, broad biochemical capacity, and continuous bidirectional communication with the host. By transforming dietary, host‐derived, and environmental substrates into bioactive metabolites with endocrine‐like, immunomodulatory, and ...
Yang Bi, Weibin Song, Maria Glymenaki, Jie Hu, Xiru Li, Heng Huang, Yousong Peng, Shuaishuai Ni, Ornuma Haonon, Zhu Liu, Krai Daowtak, Xiaotao Shen, Huadong Peng, Jutarop Phetcharaburanin, Huiru Tang, Yulan Wang, Jia V. Li, Mizu Jiang, Nick Powell, Victor W. Zhong, Elaine Holmes, Yunlei Xianyu, Zhigang Liu   +22 more
wiley   +1 more source