Results 71 to 80 of about 5,446 (188)
International Endodontic Journal, Volume 59, Issue 2, Page 225-237, February 2026.ABSTRACT Aims To investigate the effects of Porphyromonas endodontalis on the viability of stem cells from the apical papilla (SCAP) and to explore the role of mitochondrial function in supporting SCAP survival. Methodology SCAP were isolated from immature third molars, and P. endodontalis was added to the cell culture medium.
S. Lei +7 more
wiley +1 more source
Risk predisposition for Crohn disease A "menage a trois" combining IRGM allele, miRNA and xenophagy
, 2011 International audienceSusceptibility to Crohn disease (CD), an inflammatory bowel disease, is influenced by common variants at many loci like the exonic synonymous IRGM SNP (rs10065172, NM_001145805.1, c.313C>T).
Brest, Patrick +9 more
core +1 more source
Mycobacterium bovis induces mitophagy to suppress host xenophagy for its intracellular survival
, 2021 Mitophagy is a selective autophagy mechanism for eliminating damaged mitochondria and plays a crucial role in the immune evasion of some viruses and bacteria. Here, we report that Mycobacterium bovis (M.
Tariq Hussain (607201) +8 more
core +1 more source
Clinical &Translational Immunology, Volume 15, Issue 1, 2026.In this study, we analysed the immune responses of blood‐derived monocyte macrophages and iPSC‐derived macrophages following BCG/HKMT infection. We found that iPSC‐derived macrophages displayed a markedly stronger activation profile, including faster migration, increased reactive oxygen species production, elevated apoptosis marker expression and ...
Daniela Paasch +17 more
wiley +1 more source
, 2018 Autophagy is an important process for cell survival in the human body, which plays a critical role in fighting infections. Some infections exploit the autophagic system and are often promoted by autophagy.
Radhi, Ohood Aqeed
core +2 more sources
Ubiquilin 1 Promotes IFN-γ-Induced Xenophagy of Mycobacterium tuberculosis
PLOS Pathogens, 2015 The success of Mycobacterium tuberculosis (Mtb) as a pathogen rests upon its ability to grow intracellularly in macrophages. Interferon-gamma (IFN-γ) is critical in host defense against Mtb and stimulates macrophage clearance of Mtb through an autophagy pathway.
Erik T Sakowski +8 more
openaire +3 more sources
Autophagy: A new strategy for host-directed therapy of tuberculosis
Virulence, 2019 Tuberculosis (TB), which is primarily caused by the major etiologic agent Mycobacterium tuberculosis (Mtb), remains a serious infectious disease worldwide.
Seungwha Paik +3 more
doaj +1 more source
Pathogens, 2016 Varicella-zoster virus (VZV) induces abundant autophagy. Of the nine human herpesviruses, the VZV genome is the smallest (~124 kbp), lacking any known inhibitors of autophagy, such as the herpes simplex virus ICP34.5 neurovirulence gene.
Charles Grose +3 more
doaj +1 more source
Gastroenterology Research and Practice, Volume 2026, Issue 1, 2026.Helicobacter pylori–associated gastritis (HPAG) is a chronic inflammatory condition of the gastric mucosa caused by Helicobacter pylori infection, serving as the core etiological factor for peptic ulcers and gastric precancerous lesions. Given the persistently high global infection rates and the escalating burden of antibiotic resistance, conventional ...
Zhongyao Fan +5 more
wiley +1 more source
Multiomics Integration Reveals Genetic, Metabolic, and Microbial Signatures of Crohn′s Disease
Human Mutation, Volume 2026, Issue 1, 2026.Crohn′s disease (CD) is a complex inflammatory bowel disorder with multifactorial etiology involving genetic susceptibility, metabolic dysregulation, and intestinal microbiome alterations. Although individual omics studies have provided insights into CD pathogenesis, integrative analyses linking these molecular layers remain limited. Here, we performed
Xianguo Qu +5 more
wiley +1 more source