Results 71 to 80 of about 4,824 (164)

Nanomedicine Approaches for Autophagy Modulation in Cancer Therapy

Small Science, Volume 5, Issue 6, June 2025.
Autophagy modulation holds promise for enhancing cancer treatment, yet clinical translation remains challenging. This review explores nanomedicine‐based strategies to improve autophagy‐targeting drugs, highlighting their synergy with chemotherapy, immunotherapy, phototherapy, and gene therapy. It also discusses nanoparticle design and clinical progress,
Sohaib Mahri, Rodolfo Villa, Ya‐Ping Shiau, Menghuan Tang, Kelsey Jane Racacho, Qiufang Zong, Saiful Islam Chowdhury, Tan Hua, Felipe Godinez, Andrew Birkeland, Tzu‐Yin Lin, Yuanpei Li   +11 more
wiley   +1 more source

ULK1‐mediated phosphorylation of ATG16L1 promotes xenophagy, but destabilizes the ATG16L1 Crohn's mutant [PDF]

EMBO reports, 2019
Autophagy is a highly regulated catabolic pathway that is potently induced by stressors including starvation and infection. An essential component of the autophagy pathway is an ATG16L1-containing E3-like enzyme, which is responsible for lipidating LC3B and driving autophagosome formation.
Alsaadi, Reham M, Losier, Truc T, Tian, Wensheng, Jackson, Anne, Guo, Zhihao, Rubinsztein, David C, Russell, Ryan C   +6 more
openaire   +2 more sources

Salmonella Interacts With Autophagy to Offense or Defense

Frontiers in Microbiology, 2020
Autophagy is an important component of the innate immune system in mammals. Low levels of basic autophagy are sustained in normal cells, to help with the clearance of aging organelles and misfolded proteins, thus maintaining their structural and ...
Shu Wu, Shu Wu, Shu Wu, Yiru Shen, Yiru Shen, Shan Zhang, Shan Zhang, Yunqi Xiao, Yunqi Xiao, Shourong Shi, Shourong Shi, Shourong Shi   +11 more
doaj   +1 more source

Macrophages and autophagy: partners in crime

The FEBS Journal, Volume 292, Issue 12, Page 2957-2972, June 2025.
Autophagy is a key regulator of macrophage function, influencing critical processes like polarization, cytokine secretion, and phagocytosis. Its impact on macrophage behavior varies across different tissues and disease contexts, where it can either promote protective responses or contribute to detrimental outcomes, depending on the physiological or ...
Alessandra Vitaliti, Alessio Reggio, Alessandro Palma   +2 more
wiley   +1 more source

Cost‐effective and simple flow cytometry quantification of receptor‐mediated autophagy using fluorescent tagging

FEBS Open Bio, Volume 15, Issue 4, Page 587-598, April 2025.
Mitophagy, the selective degradation of damaged mitochondria, is crucial for cellular health and function. This study introduces a rapid and efficient flow cytometry method using GFP‐BNIP3L/NIX to accurately quantify mitophagy. Our approach can be adapted to use any fluorescent‐tagged selective autophagy receptor, enabling direct and rapid analysis of ...
Mija Marinković, Ana Rožić, Denis Polančec, Ivana Novak   +3 more
wiley   +1 more source

Restriction of intracellular Salmonella replication by restoring TFEB-mediated xenophagy

Autophagy, 2019
Macroautophagy/autophagy functions as a part of the innate immune system in clearing intracellular pathogens. Although this process is well known, the mechanisms that control antibacterial autophagy are not clear. In this study we show that during intracellular Salmonella typhimurium infection, the activity of TFEB (transcription factor EB), a master ...
Veena, Ammanathan, Piyush, Mishra, Aravinda K, Chavalmane, Sasikumar, Muthusamy, Vidya, Jadhav, Chandrashekaran, Siddamadappa, Ravi, Manjithaya   +6 more
openaire   +3 more sources

Ubiquitin and Ubiquitin‐Like Modifications in Organelle Stress Signaling: Ub, Ub, Ub, Ub, Stayin’ Alive, Stayin’ Alive

BioEssays, Volume 47, Issue 2, February 2025.
ABSTRACT Due to various intracellular and external cues, cellular organelles are frequently stressed in both physiological and pathological conditions. Sensing these stresses initiates various signaling pathways which may lead to adaptation of the stressed cells or trigger its their death.
Elodie Lafont, Eric Chevet
wiley   +1 more source

Hantaan virus glycoprotein Gc induces NEDD4‐dependent PTEN ubiquitination and degradation to escape the restriction of autophagosomes and facilitate viral propagation

The FASEB Journal, Volume 39, Issue 1, 15 January 2025.
The proposed model of HTNV induced PTEN degradation and PTEN‐regulated autophagy in progeny virus production: In HTNV‐infected HK‐2 cells, the viral Gc glycoprotein specifically promotes NEDD4 mediated ubiquitination and degradation of PTEN. Disruption of PTEN expression prevents autophagosome formation and increases HTNV production, whereas ...
Shuang Lu, Shuliang Chen, Yuqing Zhang, Xiaoli Mou, Mingyang Li, Shaowei Zhu, Xingyuan Chen, Tomas M. Strandin, Yale Jiang, Zhoufu Xiang, Yuanyuan Liu, Hairong Xiong, Deyin Guo, Liangjun Chen, Yirong Li, Wei Hou, Fan Luo   +16 more
wiley   +1 more source

How Shigella tackles host defences

eLife
The pathogenic bacteria Shigella avoids detection inside hosts cells by degrading RNF213, the protein responsible for sensing the presence of intracellular pathogens.
Yizhou Huang, Teresa LM Thurston
doaj   +1 more source

Studying Autophagy in Zebrafish

Cells, 2017
Autophagy is an evolutionarily conserved catabolic process which allows lysosomal degradation of complex cytoplasmic components into basic biomolecules that are recycled for further cellular use.
Benan John Mathai, Annemarie H. Meijer, Anne Simonsen   +2 more
doaj   +1 more source