Results 81 to 90 of about 4,824 (164)

Novel Mechanism of the L‐Type Voltage‐Gated Channels/Calpains Axis in Influenza A Virus‐Induced Autophagosome Activity

Journal of Medical Virology, Volume 97, Issue 10, October 2025.
Hannah Murphy, Hinh Ly
wiley   +1 more source

Staphylococcus aureus persistence in osteocytes: weathering the storm of antibiotics and autophagy/xenophagy

Frontiers in Cellular and Infection Microbiology
Staphylococcus aureus is a major causative pathogen of osteomyelitis. Intracellular infections of resident bone cells including osteocytes can persist despite gold-standard clinical intervention. The mechanisms by which intracellular S. aureus evades antibiotic therapy are unknown. In this study, we utilised an in vitro S.
Nicholas J. Gunn, Stephen P. Kidd, Stephen P. Kidd, Lucian B. Solomon, Lucian B. Solomon, Dongqing Yang, Eugene Roscioli, Eugene Roscioli, Eugene Roscioli, Gerald J. Atkins   +9 more
openaire   +3 more sources

COPD-Related Modification to the Airway Epithelium Permits Intracellular Residence of Nontypeable Haemophilus influenzae and May Be Potentiated by Macrolide Arrest of Autophagy

International Journal of COPD, 2020
Wee-Peng Poh,1 Anthony Kicic,1– 5 Susan E Lester,6 Phan T Nguyen,7,8 Lauren O Bakaletz,9 Paul N Reynolds,7,8 Sandra Hodge,7,8 Eugene Roscioli7,8 1Telethon Kids Institute, Centre for Health Research, The University of Western Australia, Nedlands ...
Poh WP, Kicic A, Lester SE, Nguyen PT, Bakaletz LO, Reynolds PN, Hodge S, Roscioli E   +7 more
doaj  

Macrophage Autophagy and Bacterial Infections

Frontiers in Immunology, 2017
Autophagy is a well-conserved lysosomal degradation pathway that plays key roles in bacterial infections. One of the most studied is probably xenophagy, the selective capture and degradation of intracellular bacteria by lysosomes.
Aïcha Bah, Isabelle Vergne
doaj   +1 more source

The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy.

PLoS Pathogens, 2015
Autophagy plays a key role during Salmonella infection, by eliminating these pathogens following escape into the cytosol. In this process, selective autophagy receptors, including the myosin VI adaptor proteins optineurin and NDP52, have been shown to ...
David A Tumbarello, Paul T Manna, Mark Allen, Mark Bycroft, Susan D Arden, John Kendrick-Jones, Folma Buss   +6 more
doaj   +1 more source

Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy

mBio, 2019
Group A streptococcus (GAS) is an important human pathogen which can cause fatal diseases after invasion into the bloodstream. Although antibiotics and immune surveillance are the main defenses against GAS infection, GAS utilizes internalization into ...
Yi-Lin Cheng, Chih-Feng Kuo, Shiou-Ling Lu, Hiroko Omori, Ya-Na Wu, Cheng-Lu Hsieh, Takeshi Noda, Shang-Rung Wu, Robert Anderson, Chiou-Feng Lin, Chia-Ling Chen, Jiunn-Jong Wu, Yee-Shin Lin   +12 more
doaj   +1 more source

xenophagy

Citation: 'xenophagy' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13791 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Resveratrol-Induced Xenophagy Promotes Intracellular Bacteria Clearance in Intestinal Epithelial Cells and Macrophages

Frontiers in Immunology, 2019
Autophagy is a lysosomal degradation process that contributes to host immunity by eliminating invasive pathogens and the modulating inflammatory response.
Jana Al Azzaz, Aurélie Rieu, Virginie Aires, Virginie Aires, Virginie Aires, Dominique Delmas, Dominique Delmas, Dominique Delmas, Johanna Chluba, Johanna Chluba, Pascale Winckler, Pascale Winckler, Marie-Agnès Bringer, Jérémy Lamarche, Dominique Vervandier-Fasseur, Frédéric Dalle, Pierre Lapaquette, Jean Guzzo   +17 more
doaj   +1 more source

Vaccinia virus subverts xenophagy through phosphorylation and nuclear targeting of p62

Journal of Cell Biology
Autophagy is an essential degradation program required for cell homeostasis. Among its functions is the engulfment and destruction of cytosolic pathogens, termed xenophagy. Not surprisingly, many pathogens use various strategies to circumvent or co-opt autophagic degradation. For poxviruses, it is known that infection activates autophagy, which however
Melanie Krause, Jerzy Samolej, Artur Yakimovich, Janos Kriston-Vizi, Moona Huttunen, Samuel Lara-Reyna, Eva-Maria Frickel, Jason Mercer   +7 more
openaire   +4 more sources

Xenophagy-Evasion Mechanisms by Intracellular Pathogens in Bacteria, Viruses, and Parasites

Journal of Inflammatory and Infectious Medicine
Autophagy is an essential process for maintaining cellular homeostasis. Xenophagy, a key defense mechanism, selectively degrades and eliminates pathogens such as bacteria, viruses, and parasites that have invaded the host. Host cells mark pathogens through ubiquitination. These marked pathogens are then recognized by autophagy receptors and sequestered
Minwoo Kim, Won-Hong Min, Yucheol Choe, Kwang Dong Kim   +3 more
openaire   +1 more source