Results 81 to 90 of about 5,446 (188)

Avian Pathogenic Escherichia coli T6SS Effector Protein Hcp2 Induces Mitochondrial Dysfunction and Activates Mitophagy in Chicken Tracheal Mucosal Epithelial Cells

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
The secretion system of avian pathogenic Escherichia coli (APEC) plays a key role in bacterial colonization and invasion of the host. The core structural component of the type VI secretion system (T6SS), hemolysin‐coregulatory protein (Hcp), functions both as a T6SS structural component and a secreted virulence effector.
Bingyu Zhao, Ziqi Li, Liyang Dai, Yifei Huang, Yaqin Tian, Xiyang Wei, Chenchen Sheng, Zhenyu Wang, Ying Shao, Jiumeng Sun, Jian Tu, Xiangjun Song, Zhong Peng   +12 more
wiley   +1 more source

TGM2 promotes intracellular persistence of Staphylococcus aureus by aggravating xenophagy dysfunction in bovine mammary epithelial cells

Staphylococcus aureus ( S. aureus ) is a major contagious pathogen responsible for persistent bovine mastitis, in part because it can survive within bovine mammary epithelial cells.
Long Guo, Kangjun Liu, Xia Meng, Junsheng Dong, Jianji Li, Luying Cui, Li Fang, LuanYu Ni, Heng Wang   +8 more
core   +1 more source

Chemical modulation of SQSTM1/p62-mediated xenophagy that targets a broad range of pathogenic bacteria

, 2022
The N-degron pathway is a proteolytic system in which the N-terminal degrons (N-degrons) of proteins, such as arginine (Nt-Arg), induce the degradation of proteins and subcellular organelles via the ubiquitin-proteasome system (UPS) or macroautophagy ...
Kwon, Yong Tae, Jung, Eui Jung, Shim, Sang Mi, Lee, Su Hyun, Kim, Young Jae, Choi, Ha Rim, Kim, Jin Kyung, Hur, Gang Min, Jeon, Sang Min, Jo, Eun-Kyeong, Son, Yeon Sung, Whang, Jake, Yeom, Jinki, Lee, Yoon Jee, Lee, Sang-Hee, Jung, Chan Hoon, Choe, Jin Ho, Sohn, Kyung-Cheol, Kim, Hyun Tae   +18 more
core   +1 more source

Autophagy plays a protective role against Trypanosoma cruzi infection in mice

Virulence, 2019
Autophagy is a catabolic pathway required for cellular and organism homeostasis. Autophagy participates in the innate and adaptive immune responses at different levels.
Ana Florencia Casassa, María Cristina Vanrell, María Isabel Colombo, Roberta A. Gottlieb, Patricia Silvia Romano   +4 more
doaj   +1 more source

Salmonella Interacts With Autophagy to Offense or Defense

Frontiers in Microbiology, 2020
Autophagy is an important component of the innate immune system in mammals. Low levels of basic autophagy are sustained in normal cells, to help with the clearance of aging organelles and misfolded proteins, thus maintaining their structural and ...
Shu Wu, Shu Wu, Shu Wu, Yiru Shen, Yiru Shen, Shan Zhang, Shan Zhang, Yunqi Xiao, Yunqi Xiao, Shourong Shi, Shourong Shi, Shourong Shi   +11 more
doaj   +1 more source

Modulation of host cell pathways by Coxiella burnetii Dot/Icm effectors

mLife, Volume 4, Issue 6, Page 577-596, December 2025.
Abstract Coxiella burnetii, the etiological agent of Q fever, is a significant intracellular bacterial pathogen. C. burnetii is a highly infectious pathogen that primarily targets pulmonary alveolar macrophages during natural infection. It can then disseminate to macrophages in other tissues and organs, leading to chronic infections. C.
Jingya Yuan, Yong Zhang, Lei Song, Zhao‐Qing Luo   +3 more
wiley   +1 more source

Eating the strangers within: host control of intracellular bacteria via xenophagy

, 2011
Many bacterial pathogens rely on an intracellular cycle to ensure their proliferation within infected hosts, through their ability to avoid or circumvent host bactericidal pathways.
Celli, Jean, Leigh A. Knodler, Knodler, Leigh A, Jean Celli   +3 more
core   +1 more source

<i>Tropheryma whipplei</i> escapes LAPosome and modulates macrophage response in a xenophagy-dependent manner. [PDF]

Autophagy Rep
Tropheryma whipplei, the agent of Whipple’s disease, is an intracellular pathogen that replicates in macrophages. The phagocytic and cellular processes leading to the formation of T. whipplei replicative vacuole remain poorly understood.
Reyne E, Arrindell J, Bestion E, Mezouar S, Desnues B.   +4 more
europepmc   +2 more sources

Host Translational Control by Stress Granules Promotes Mycobacterium tuberculosis Pathogenesis

MedComm, Volume 6, Issue 11, November 2025.
During Mycobacterium tuberculosis infection, stress granules (SGs) formed in macrophages sequester key signaling and metabolic regulators such as mTORC1 components (mTOR, Raptor) and mitochondrial complex I subunits (Ndufa12), leading to suppressed cap‐dependent translation, reduced mitochondrial activity, and impaired innate immune responses.
Jaewhan Kim, Sang‐Hun Son, Ji‐Ae Choi, Junghwan Lee, Seoyeon Jo, Soo‐Na Cho, Doan Tam Nguyen, Doyi Son, Kee K. Kim, Chang‐Hwa Song   +9 more
wiley   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source