Results 101 to 110 of about 5,446 (188)

ULK1-mediated phosphorylation of ATG16L1 promotes xenophagy, but destabilizes the ATG16L1 Crohn's mutant. [PDF]

, 2019
Autophagy is a highly regulated catabolic pathway that is potently induced by stressors including starvation and infection. An essential component of the autophagy pathway is an ATG16L1-containing E3-like enzyme, which is responsible for lipidating LC3B ...

core   +2 more sources

The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy.

PLoS Pathogens, 2015
Autophagy plays a key role during Salmonella infection, by eliminating these pathogens following escape into the cytosol. In this process, selective autophagy receptors, including the myosin VI adaptor proteins optineurin and NDP52, have been shown to ...
David A Tumbarello, Paul T Manna, Mark Allen, Mark Bycroft, Susan D Arden, John Kendrick-Jones, Folma Buss   +6 more
doaj   +1 more source

Image_2_Resveratrol-Induced Xenophagy Promotes Intracellular Bacteria Clearance in Intestinal Epithelial Cells and Macrophages.TIF

, 2019
Autophagy is a lysosomal degradation process that contributes to host immunity by eliminating invasive pathogens and the modulating inflammatory response.
Aurélie Rieu (6202877), Jérémy Lamarche (6202883), Virginie Aires (6202880), Frédéric Dalle (5657071), Pierre Lapaquette (600850), Dominique Vervandier-Fasseur (6202886), Dominique Delmas (217098), Johanna Chluba (701935), Jean Guzzo (6202889), Jana Al Azzaz (6202874), Pascale Winckler (1272483), Marie-Agnès Bringer (349597)   +11 more
core   +1 more source

xenophagy

Citation: 'xenophagy' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13791 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Novel Mechanism of the L‐Type Voltage‐Gated Channels/Calpains Axis in Influenza A Virus‐Induced Autophagosome Activity

Journal of Medical Virology, Volume 97, Issue 10, October 2025.
Hannah Murphy, Hinh Ly
wiley   +1 more source

Schematic model of Salmonella xenophagy.

, 2016
Inside lumen of the mammalian small intestine, Salmonella invades epithelial cells and resides within the SCV. A fraction of the bacteria does not persist inside the SCV and enters the host cytosol.
Ina Koch (7903), Jörg Ackermann (474983), Leonie Amstein (3372488), Ivan Dikic (24996), Jennifer Scheidel (3372491)   +4 more
core   +1 more source

Bacterial Pathogens versus Autophagy: Implications for Therapeutic Interventions [PDF]

, 2016
Research in recent years has focused significantly on the role of selective macroautophagy in targeting intracellular pathogens for lysosomal degradation, a process termed xenophagy.
Stallings, Christina L, Kimmey, Jacqueline M   +1 more
core   +1 more source

ER-stress mobilization of death-associated protein kinase-1–dependent xenophagy counteracts mitochondria stress–induced epithelial barrier dysfunction

, 2018
The gut microbiome contributes to inflammatory bowel disease (IBD), in which bacteria can be present within the epithelium. Epithelial barrier function is decreased in IBD, and dysfunctional epithelial mitochondria and endoplasmic reticulum (ER) stress ...
Cristiane H. Baggio, Jong M. Rho, McKay, Derek M.,, McKay, Derek M, Younghee Ahn, Keita, Åsa,, Jijon, Humberto,, Dicay, Michael, Rho, Jong M, Keita, Åsa V, Lopes, Fernando,, Dicay, Michael,, Al Rajabi, Ala, Alpana Saxena, Söderholm, Johan D, van Dalen, Rob,, Peters, Nathan C.,, Philpott, Dana J, Saxena, Alpana,, MacNaughton, Wallace K, Mancini, Nicole L.,, Wallace K. MacNaughton, Baggio, Cristiane H, Ahn, Younghee, Jijon, Humberto, Baggio, Cristiane H.,, Philpott, Dana J.,, Nicole L. Mancini, Reyes, Jose Luis,, Fernando Lopes, van Dalen, Rob, Carneiro, Matheus B. H.,, Söderholm, Johan D,, Åsa V. Keita, Michael Dicay, Rho, Jong M.,, Mancini, Nicole L, Reyes, Jose Luis, Derek M. McKay, Carneiro, Matheus BH, Al Rajabi, Ala,, Girardin, Stephen E.,, Arthur Wang, Nathan C. Peters, Ahn, Younghee,, Matheus B.H. Carneiro, MacNaughton, Wallace K.,, Peters, Nathan C, Saxena, Alpana, Stephen E. Girardin, Rob van Dalen, Lopes, Fernando, Ala Al Rajabi, Girardin, Stephen E, Wang, Arthur,, Humberto Jijon, Dana J. Philpott, Wang, Arthur, Jose Luis Reyes, Johan D. Söderholm   +59 more
core   +1 more source

Staphylococcus aureus persistence in osteocytes: weathering the storm of antibiotics and autophagy/xenophagy

Frontiers in Cellular and Infection Microbiology
Staphylococcus aureus is a major causative pathogen of osteomyelitis. Intracellular infections of resident bone cells including osteocytes can persist despite gold-standard clinical intervention. The mechanisms by which intracellular S. aureus evades antibiotic therapy are unknown. In this study, we utilised an in vitro S.
Nicholas J. Gunn, Stephen P. Kidd, Stephen P. Kidd, Lucian B. Solomon, Lucian B. Solomon, Dongqing Yang, Eugene Roscioli, Eugene Roscioli, Eugene Roscioli, Gerald J. Atkins   +9 more
openaire   +3 more sources

M. tuberculosis infection of human iPSC-derived macrophages reveals complex membrane dynamics during xenophagy evasion

, 2020
Xenophagy is an important cellular defence mechanism against cytosol invading pathogens, such as Mycobacterium tuberculosis (Mtb). Activation of xenophagy in macrophages targets Mtb to autophagosomes, however how Mtb is targeted to autophagosomes in ...
Rachel J Lai (9699488), Lucy M Collinson (8128938), Claudio Bussi (8273070), Elliott M Bernard (8841155), Christopher J Peddie (8272917), Maximiliano G Gutierrez (8133912), Antony Fearns (9045272), Pierre Santucci (3396611)   +7 more
core