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Investigating the Interaction Profile of Unconjugated Ubiquitin: Chemical Biology and Affinity Enrichment Mass Spectrometric Approaches

ChemBioChem, Volume 26, Issue 18, September 18, 2025.
This mini review provides insights into the synergistic power of chemical biology techniques for generating defined ubiquitin (Ub) variants and the use of affinity enrichment mass spectrometry to decipher the Ub code. It focuses on unconjugated Ub variants, which have emerged as additional signaling molecules in the Ub lexicon. Furthermore, it outlines
Simon Maria Kienle, Katrin Stuber
wiley   +1 more source

Selective Autophagy in Plant Immunity: Mechanisms, Regulation, and Emerging Concepts in Xenophagy

Selective autophagy has emerged as a critical component of plant immunity, yet its role as a dedicated antimicrobial mechanism, xenophagy, remains conceptually underdeveloped.
Deepika Dake, Laha Supriya, Padmaja Gudipalli, Mehanathan Muthamilarasan, Namisha Sharma, Pooja Shukla   +5 more
core   +1 more source

How Shigella tackles host defences

eLife
The pathogenic bacteria Shigella avoids detection inside hosts cells by degrading RNF213, the protein responsible for sensing the presence of intracellular pathogens.
Yizhou Huang, Teresa LM Thurston
doaj   +1 more source

Studying Autophagy in Zebrafish

Cells, 2017
Autophagy is an evolutionarily conserved catabolic process which allows lysosomal degradation of complex cytoplasmic components into basic biomolecules that are recycled for further cellular use.
Benan John Mathai, Annemarie H. Meijer, Anne Simonsen   +2 more
doaj   +1 more source

Image_3_Resveratrol-Induced Xenophagy Promotes Intracellular Bacteria Clearance in Intestinal Epithelial Cells and Macrophages.TIF

, 2019
Autophagy is a lysosomal degradation process that contributes to host immunity by eliminating invasive pathogens and the modulating inflammatory response.
Aurélie Rieu (6202877), Jérémy Lamarche (6202883), Virginie Aires (6202880), Frédéric Dalle (5657071), Pierre Lapaquette (600850), Dominique Vervandier-Fasseur (6202886), Dominique Delmas (217098), Johanna Chluba (701935), Jean Guzzo (6202889), Jana Al Azzaz (6202874), Pascale Winckler (1272483), Marie-Agnès Bringer (349597)   +11 more
core   +1 more source

COPD-Related Modification to the Airway Epithelium Permits Intracellular Residence of Nontypeable Haemophilus influenzae and May Be Potentiated by Macrolide Arrest of Autophagy

International Journal of COPD, 2020
Wee-Peng Poh,1 Anthony Kicic,1– 5 Susan E Lester,6 Phan T Nguyen,7,8 Lauren O Bakaletz,9 Paul N Reynolds,7,8 Sandra Hodge,7,8 Eugene Roscioli7,8 1Telethon Kids Institute, Centre for Health Research, The University of Western Australia, Nedlands ...
Poh WP, Kicic A, Lester SE, Nguyen PT, Bakaletz LO, Reynolds PN, Hodge S, Roscioli E   +7 more
doaj  

Macrophage Autophagy and Bacterial Infections

Frontiers in Immunology, 2017
Autophagy is a well-conserved lysosomal degradation pathway that plays key roles in bacterial infections. One of the most studied is probably xenophagy, the selective capture and degradation of intracellular bacteria by lysosomes.
Aïcha Bah, Isabelle Vergne
doaj   +1 more source

Image_1_Resveratrol-Induced Xenophagy Promotes Intracellular Bacteria Clearance in Intestinal Epithelial Cells and Macrophages.TIF

, 2019
Autophagy is a lysosomal degradation process that contributes to host immunity by eliminating invasive pathogens and the modulating inflammatory response.
Aurélie Rieu (6202877), Jérémy Lamarche (6202883), Virginie Aires (6202880), Frédéric Dalle (5657071), Pierre Lapaquette (600850), Dominique Vervandier-Fasseur (6202886), Dominique Delmas (217098), Johanna Chluba (701935), Jean Guzzo (6202889), Jana Al Azzaz (6202874), Pascale Winckler (1272483), Marie-Agnès Bringer (349597)   +11 more
core   +1 more source

Deceiving The Big Eaters: Salmonella Typhimurium SopB subverts host cell Xenophagy through Akt-TFEB axis in macrophages

, 2022
Salmonella, a stealthy facultative intracellular pathogen, harbors an array of host immune evasion strategies. This facilitates successful survival and replicative niches establishment in otherwise hostile host innate immune cells such as macrophages ...
Chakravortty, Dipshikha, Chatterjee, Ritika, Chaudhuri, Debalina, Setty, Subba Rao Gangi   +3 more
core   +1 more source

HEATR3 recognizes membrane rupture and facilitates xenophagy in response to <i>Salmonella</i> invasion. [PDF]

Proc Natl Acad Sci U S A
Bacterial invasion into the cytoplasm of epithelial cells triggers the activation of the cellular autophagic machinery as a defense mechanism, a process known as xenophagy. In this study, we identified HEATR3, an LC3-interacting region (LIR)-containing protein, as a factor involved in this defense mechanism using quantitative mass ...
Arakawa M, Uriu K, Saito K, Hirose M, Katoh K, Asano K, Nakane A, Saitoh T, Yoshimori T, Morita E.   +9 more
europepmc   +4 more sources