Results 61 to 70 of about 4,824 (164)

Modulation of host cell pathways by Coxiella burnetii Dot/Icm effectors

mLife, Volume 4, Issue 6, Page 577-596, December 2025.
Abstract Coxiella burnetii, the etiological agent of Q fever, is a significant intracellular bacterial pathogen. C. burnetii is a highly infectious pathogen that primarily targets pulmonary alveolar macrophages during natural infection. It can then disseminate to macrophages in other tissues and organs, leading to chronic infections. C.
Jingya Yuan, Yong Zhang, Lei Song, Zhao‐Qing Luo   +3 more
wiley   +1 more source

Host Translational Control by Stress Granules Promotes Mycobacterium tuberculosis Pathogenesis

MedComm, Volume 6, Issue 11, November 2025.
During Mycobacterium tuberculosis infection, stress granules (SGs) formed in macrophages sequester key signaling and metabolic regulators such as mTORC1 components (mTOR, Raptor) and mitochondrial complex I subunits (Ndufa12), leading to suppressed cap‐dependent translation, reduced mitochondrial activity, and impaired innate immune responses.
Jaewhan Kim, Sang‐Hun Son, Ji‐Ae Choi, Junghwan Lee, Seoyeon Jo, Soo‐Na Cho, Doan Tam Nguyen, Doyi Son, Kee K. Kim, Chang‐Hwa Song   +9 more
wiley   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Autophagy: A new strategy for host-directed therapy of tuberculosis

Virulence, 2019
Tuberculosis (TB), which is primarily caused by the major etiologic agent Mycobacterium tuberculosis (Mtb), remains a serious infectious disease worldwide.
Seungwha Paik, Jin Kyung Kim, Chaeuk Chung, Eun-Kyeong Jo   +3 more
doaj   +1 more source

Varicella-Zoster Virus Infectious Cycle: ER Stress, Autophagic Flux, and Amphisome-Mediated Trafficking

Pathogens, 2016
Varicella-zoster virus (VZV) induces abundant autophagy. Of the nine human herpesviruses, the VZV genome is the smallest (~124 kbp), lacking any known inhibitors of autophagy, such as the herpes simplex virus ICP34.5 neurovirulence gene.
Charles Grose, Erin M. Buckingham, John E. Carpenter, Jeremy P. Kunkel   +3 more
doaj   +1 more source

Investigating the Interaction Profile of Unconjugated Ubiquitin: Chemical Biology and Affinity Enrichment Mass Spectrometric Approaches

ChemBioChem, Volume 26, Issue 18, September 18, 2025.
This mini review provides insights into the synergistic power of chemical biology techniques for generating defined ubiquitin (Ub) variants and the use of affinity enrichment mass spectrometry to decipher the Ub code. It focuses on unconjugated Ub variants, which have emerged as additional signaling molecules in the Ub lexicon. Furthermore, it outlines
Simon Maria Kienle, Katrin Stuber
wiley   +1 more source

<i>Tropheryma whipplei</i> escapes LAPosome and modulates macrophage response in a xenophagy-dependent manner. [PDF]

Autophagy Rep
Tropheryma whipplei, the agent of Whipple's disease, is an intracellular pathogen that replicates in macrophages. The phagocytic and cellular processes leading to the formation of T. whipplei replicative vacuole remain poorly understood. Macrophage microbicidal activity is largely related to macro/autophagy which is also essential for cell homeostasis.
Reyne E, Arrindell J, Bestion E, Mezouar S, Desnues B.   +4 more
europepmc   +5 more sources

A comprehensive analysis of the relationship between inflammasomes and autophagy in human tumors: Recent developments

Journal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.
The interaction between inflammasomes and autophagy is crucial for maintaining the balance between necessary immune responses and the avoidance of excessive inflammation. Autophagy can inhibit the activation of the NLRP3 inflammasome by degrading endogenous activators, such as damaged mitochondria that produce reactive oxygen species (ROS), as well as ...
Sai Liu, Jingzhou Zhang
wiley   +1 more source

An Intrinsic Host Defense against HSV-1 Relies on the Activation of Xenophagy with the Active Clearance of Autophagic Receptors

Cells
Autophagy engulfs cellular components in double-membrane-bound autophagosomes for clearance and recycling after fusion with lysosomes. Thus, autophagy is a key process for maintaining proteostasis and a powerful cell-intrinsic host defense mechanism ...
Camila Pino-Belmar, Rayén Aguilar, Guillermo E. Valenzuela-Nieto, Viviana A. Cavieres, Cristóbal Cerda-Troncoso, Valentina C. Navarrete, Paula Salazar, Patricia V. Burgos, Carola Otth, Hianara A. Bustamante   +9 more
doaj   +1 more source

Autophagy plays a protective role against Trypanosoma cruzi infection in mice

Virulence, 2019
Autophagy is a catabolic pathway required for cellular and organism homeostasis. Autophagy participates in the innate and adaptive immune responses at different levels.
Ana Florencia Casassa, María Cristina Vanrell, María Isabel Colombo, Roberta A. Gottlieb, Patricia Silvia Romano   +4 more
doaj   +1 more source