Results 61 to 70 of about 5,446 (188)

A Structural View of Xenophagy, a Battle between Host and Microbes.

Molecules and cells, 2018
The cytoplasm in mammalian cells is a battlefield between the host and invading microbes. Both the living organisms have evolved unique strategies for their survival. The host utilizes a specialized autophagy system, xenophagy, for the clearance of invading pathogens, whereas bacteria secrete proteins to defend and escape from the host xenophagy ...
Kwon, Do Hoon, Song, Hyun Kyu
openaire   +2 more sources

Xenophagy: A battlefield between host and microbe, and a possible avenue for cancer treatment [PDF]

Autophagy, 2016
In eukaryotes, xenophagy is defined as a type of selective macroautophagy/autophagy that is used for eliminating invading pathogens. In contrast to other types of selective autophagy, such as mitophagy, pexophagy and ribophagy, xenophagy is used by eukaryotes for targeting microbes-hence the prefix "xeno" meaning "other" or "foreign"-that have infected
Kai, Mao, Daniel J, Klionsky
openaire   +2 more sources

Xenophagy and Beyond: A Narrative Review on Canonical and Noncanonical Autophagy in Host Defense Against Bacterial Pathogens

Infectious Microbes & Diseases
Autophagy is a fundamental cellular process that maintains homeostasis and defends against intracellular pathogens. In particular, xenophagy, a specialized form of autophagy, plays a pivotal role in the innate immune response by targeting and eliminating
Shuai Gao, Dailin Yuan, Stijn van der Veen   +2 more
doaj   +1 more source

Autophagy in Crohn’s Disease: Converging on Dysfunctional Innate Immunity

Cells, 2023
Crohn’s disease (CD) is a chronic inflammatory bowel disease marked by relapsing, transmural intestinal inflammation driven by innate and adaptive immune responses.
Kibrom M. Alula, Arianne L. Theiss
doaj   +1 more source

Selective Autophagy Receptor CsNBR1 Confers Citrus Huanglongbing Resistance by Degrading ‘Candidatus Liberibacter Asiaticus’ Virulence Effectors

Molecular Plant Pathology, Volume 27, Issue 7, July 2026.
Overexpression of CsNBR1 confers HLB resistance in citrus by degrading CLas effector proteins, including SDE5115, SDE1, SDE19 and SDE5, via the autophagy pathway. ABSTRACT The selective autophagy receptor NEIGHBOUR OF BRCA1 (NBR1) is a key regulator of plant immunity, but its role against bacterial pathogens remains poorly understood.
Yaqian Shi, Xuejin Cui, Fang Fang, Zaiyu Yang, Yalin Mei, Shimian Ma, Changyong Zhou, Xuefeng Wang   +7 more
wiley   +1 more source

Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System

European Journal of Immunology, Volume 56, Issue 5, May 2026.
Integrated overview of host defense and immune evasion in Lyme Borreliosis. Bbsl evades immunity through tick saliva‐mediated suppression of innate defenses, TLR2/NOD2‐driven cytokine dysregulation, and interference with JAK/STAT and CIITA‐dependent antigen presentation.
Zara Karami, Hadewych J. M. ter Hofstede, Leo A. B. Joosten   +2 more
wiley   +1 more source

Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages

mBio, 2021
Mycobacterium tuberculosis (Mtb) causes one of the deadliest infectious diseases worldwide. Upon infection, Mtb is phagocytosed by macrophages and uses its virulence-associated ESX-1 secretion system to modulate the host cell.
Samantha L. Bell, Kayla L. Lopez, Jeffery S. Cox, Kristin L. Patrick, Robert O. Watson   +4 more
doaj   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, Volume 293, Issue 8, Page 2314-2340, April 2026.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Interplay between septins and ubiquitin-mediated xenophagy during Shigella entrapment

Autophagy Reports, 2023
Septins are cytoskeletal proteins implicated in numerous cellular processes including cytokinesis and morphogenesis. In the case of infection by Shigella flexneri, septins assemble into cage-like structures that entrap cytosolic bacteria targeted by autophagy. The interplay between septin cage entrapment and bacterial autophagy is poorly understood. We
Damián Lobato-Márquez, José Javier Conesa, Ana Teresa López-Jiménez, Michael E. Divine, Jonathan N. Pruneda, Serge Mostowy   +5 more
openaire   +3 more sources

Regulation of autophagy‐mediated pathways by diet, physical activity, and sleep in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease (AD) is a progressive, age‐related, neurodegenerative disorder marked by cognitive decline, memory loss, and accumulation of amyloid beta (Aβ) plaques and tau tangles. A key feature of AD is impaired protein homeostasis, often driven by autophagy dysfunction.
Ajish Ariyath, Zoe Mputhia, Christopher Dougherty, Bushra Kaleelur Rahuman, W. M. A. D. Binosha Fernando, Belinda Brown, Samantha L. Gardener, Stephanie R. Rainey‐Smith, Ralph Martins, Prashant Bharadwaj   +9 more
wiley   +1 more source