Results 61 to 70 of about 166,195 (340)

Macrophage autophagy in atherosclerosis [PDF]

, 2013
Macrophages play crucial roles in atherosclerotic immune responses. Recent investigation into macrophage autophagy (AP) in atherosclerosis has demonstrated a novel pathway through which these cells contribute to vascular inflammation.
Carnuccio, R., Grassia, G., Ialenti, A., Maffia, P., Maiuri, M.C., Platt, A.   +5 more
core   +2 more sources

Emerging role of selective autophagy in human diseases.

Frontiers in Pharmacology, 2014
Autophagy was originally described as a highly conserved system for the degradation of cytosol through a lysosome-dependent pathway. In response to starvation, autophagy degrades organelles and proteins to provide metabolites and energy for its pro ...
Kenji eMizumura, Augustine M.K. Choi, Stefan W. Ryter   +2 more
doaj   +1 more source

TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival

Cell
Pauline Lascaux, Gwendoline Hoslett, Sara Tribble, Camilla Trugenberger, Ivan Antičević, Cécile Otten, Ignacio Torrecilla, Stelios Koukouravas, Yichen Zhao, Hongbin Yang, Ftoon Aljarbou, Annamaria Ruggiano, Wei Song, Cristiano Peron, Giulio Deangeli, Enric Domingo, James Bancroft, Loïc Carrique, Errin Johnson, Iolanda Vendrell, Román Fischer, Alvin Wei Tian Ng, Joanne Ngeow, Vincenzo D’Angiolella, Nuno Raimundo, Tim Maughan, Marta Popović, Ira Milošević, Kristijan Ramadan   +28 more
openalex   +3 more sources

Ubiquitin, Autophagy and Neurodegenerative Diseases

Cells, 2020
Ubiquitin signals play various roles in proteolytic and non-proteolytic functions. Ubiquitin signals are recognized as targets of the ubiquitin–proteasome system and the autophagy–lysosome pathway.
Yoshihisa Watanabe, Katsutoshi Taguchi, Masaki Tanaka   +2 more
doaj   +1 more source

Signal transducer and activator of transcription-1 localizes to the mitochondria and modulates mitophagy [PDF]

, 2013
The signal transducer and activator of transcription (STAT) proteins are latent transcription factors that have been shown to be involved in cell proliferation, development, apoptosis, and autophagy. STAT proteins undergo activation by phosphorylation at
Ambrosio G, Coffer P, Decker RS, Decker RS, Harrison DA, Luo H, Menegazzi M, Sybers HD, Townsend PA, Turkson J   +9 more
core   +1 more source

HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa [PDF]

, 2018
The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing.
A Criollo, A Hamacher-Brady, A Hamacher-Brady, A Rita Di, A Rita Di, A Rozenknop, A Sali, A Sprenger, A Stolz, A Tanaka, AY Abramov, B Richter, C Margreitter, D Knight, DW Choi, EM Valente, F Strappazzon, F Strappazzon, F Strappazzon, F Strappazzon, G Ashrafi, G Xu, GA Khoury, GP Leboucher, H Sandoval, H Tomita, H Zhou, I Matic, I Novak, J Kitchen, JJ Lemasters, JL Parsons, JM Heo, K Sugawara, K Yamano, L Liu, LA Kane, M Campanella, M Karbowski, M Laforge, M Lazarou, M Pasi, M Pilli, M Tiberti, M Tiberti, MJ Abraham, MP Williamson, N Bakkar, N Shembade, NC Chan, P Bjelkmar, P Wild, Q Zhong, RK Dagda, S Inoue, S Piana, T Kitada, T Murakawa, T Tatsuta, TN Nguyen, V Cianfanelli, VV Rogov, VV Rogov, VV Rogov, W Zhang, Y Chen, Y Ichimura, Y Wei, Y Xue, Y Yuan, Y Zhu   +70 more
core   +4 more sources

DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose [PDF]

, 2015
Macroautophagy is a membrane-trafficking process that delivers cytoplasmic constituents to lysosomes for degradation. The process operates under basal conditions as a mechanism to turnover damaged or misfolded proteins and organelles. As a result, it has
A Kuma, A Stolz, AD Baudot, AM Choi, B Levine, B Levine, B Ravikumar, D Crighton, D Crighton, D Crighton, D Strachan, DJ Klionsky, DW Hailey, EL Axe, EL Eskelinen, F Beaumatin, F Corpet, H Harlin, I Kissova, J O'Prey, J O'Prey, J S Long, J Skommer, JJ Lemasters, JJ Lum, JS Long, K M Ryan, KM Ryan, KM Ryan, L Cong, L Y Lao, LA Bell, LY Mah, M Mrschtik, M O'Prey, MT Rosenfeldt, MT Rosenfeldt, N Mizushima, N Mizushima, P Boya, S Hehlgans, S Wilkinson, SA Tooze, SW Tait, Y Kabeya, Y Kamada, Y Ohsumi, Z Xie   +47 more
core   +2 more sources

Translation inhibition by rocaglates activates a species-specific cell death program in the emerging fungal pathogen Candida auris [PDF]

, 2020
Fungal infections are a major contributor to infectious disease-related deaths worldwide. Recently, global emergence of the fungal pathogen Candida auris has caused considerable concern because most C.
Brown, Lauren E., Cowen, Leah E., Henkel, Thomas, Iyer, Kali R., Porco, Jr., John A., Robbins, Nicole, Whitesell, Luke   +6 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source