Results 41 to 50 of about 11,891 (170)
Beyond Atg8 binding: The role of AIM/LIR motifs in autophagy [PDF]
Autophagy, 2017 Selective macroautophagy/autophagy mediates the selective delivery of cytoplasmic cargo material via autophagosomes into the lytic compartment for degradation. This selectivity is mediated by cargo receptor molecules that link the cargo to the phagophore (the precursor of the autophagosome) membrane via their simultaneous interaction with the cargo and
Dorotea Fracchiolla +2 more
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N-terminal β-strand underpins biochemical specialization of an ATG8 isoform.
PLoS Biology, 2019 Autophagy-related protein 8 (ATG8) is a highly conserved ubiquitin-like protein that modulates autophagy pathways by binding autophagic membranes and a number of proteins, including cargo receptors and core autophagy components.
Erin K Zess +16 more
doaj +1 more source
Analysis of Autophagic Activity Using ATG8 Lipidation Assay in Arabidopsis thaliana
Bio-Protocol, 2018 As a fundamental metabolic pathway to degrade and recycle cellular cargos, autophagy is highly induced upon stress, starvation and senescence conditions in plants.
Mengqian Luo, Xiaohong Zhuang
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Biological functions of the autophagy-related proteins Atg4 and Atg8 in Cryptococcus neoformans.
PLoS ONE, 2020 Autophagy is a mechanism responsible for intracellular degradation and recycling of macromolecules and organelles, essential for cell survival in adverse conditions.
Thiago Nunes Roberto +4 more
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Real-Time Monitoring of ATG8 Lipidation in vitro Using Fluorescence Spectroscopy
Bio-ProtocolAutophagy is an essential catabolic pathway used to sequester and engulf cytosolic substrates via a unique double-membrane structure, called an autophagosome.
Wenxin Zhang +2 more
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Mechanism of cargo-directed Atg8 conjugation during selective autophagy
eLife, 2016 Selective autophagy is mediated by cargo receptors that link the cargo to the isolation membrane via interactions with Atg8 proteins. Atg8 proteins are localized to the membrane in an ubiquitin-like conjugation reaction, but how this conjugation is ...
Dorotea Fracchiolla +10 more
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Identification of Atg8 Isoform in Encysting Acanthamoeba
The Korean Journal of Parasitology, 2013 Autophagy-related protein 8 (Atg8) is an essential component of autophagy formation and encystment of cyst-forming parasites, and some protozoa, such as, Acanthamoeba, Entamoeba, and Dictyostelium, have been reported to possess a type of Atg8. In this study, an isoform of Atg8 was identified and characterized in Acanthamoeba castellanii (AcAtg8b ...
Moon, Eun-Kyung +3 more
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Journal of FungiAutophagy, a conserved cellular recycling process, plays a crucial role in maintaining homeostasis under stress conditions. It also regulates the development and virulence of numerous filamentous fungi.
Qingru Geng +12 more
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Structure and Dynamics in the ATG8 Family From Experimental to Computational Techniques
Frontiers in Cell and Developmental Biology, 2020 Autophagy is a conserved and essential intracellular mechanism for the removal of damaged components. Since autophagy deregulation is linked to different kinds of pathologies, it is fundamental to gain knowledge on the fine molecular and structural ...
Valentina Sora +6 more
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Lipidation status of single membrane-associated ATG8 proteins
Trends in Biochemical Sciences, 2021 ATG8 are core autophagy proteins, the lipidated forms of which decorate double-membraned autophagosomes, as well as single-membraned organelles such as endolysosomes. Recent studies from the Florey and Münz laboratories delineate the status of single membrane-associated ATG8 proteins by indicating that their membrane anchoring can involve ...
Viret, Christophe, Faure, Mathias
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