Results 41 to 50 of about 429 (86)

Methionine Restriction Extends Yeast Lifespan by Activating Non‐Nitrogen‐Starvation‐Induced Autophagy Through Limiting Methylation of Protein Phosphatase 2A

Aging Cell, Volume 25, Issue 6, June 2026.
Methionine restriction extends yeast replicative and chronological lifespan as a consequence of depletion of S‐adenosylmethionine (SAM). SAM depletion leads to demethylation of PP2A and increased phosphorylation of Npr2 which activates non‐nitrogen‐starvation (NNS) induced autophagy; early methionine restriction is sufficient to activate persistent ...
Kaylah Birmingham, Nina Arslanovic, Thea Grauer, Ignacio Gutierrez, Ujani Chakraborty, Simone Sidoli, Jessica Tyler   +6 more
wiley   +1 more source

Blm10/PA200‐Activated 20S Proteasomes Promote α‐Synuclein Degradation and Bypass Proteasome Inhibition in Parkinson's Disease Models

Aging Cell, Volume 25, Issue 6, June 2026.
This study demonstrates that α‐synuclein expression stabilizes the proteasome activator Blm10, thereby linking α‐synuclein stress to changes in proteasome composition. Blm10/PA200‐capped 20S proteasomes efficiently degrade both monomeric and oligomeric α‐synuclein and remain resistant to α‐synuclein‐induced inhibition.
Tariq T. Ali, Anton Zhornyak, Madiha Merghani, Zora Buschenlange, Eri Sakata, Tiago F. Outeiro, Blagovesta Popova, Gerhard H. Braus   +7 more
wiley   +1 more source

Septins in the Middle—Makers and Breakers of Membrane Contact Sites

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Septins are a family of GTP‐binding proteins that assemble into heteromeric oligomers and polymers, associating with specific membrane domains and organelles according to their subunit composition. Growing evidence places septins at membrane contact sites (MCS) — key hubs for intracellular communication that mediate exchange of ions, lipids, and ...
TrishaJean J. Holt, Elias T. Spiliotis
wiley   +1 more source

The Small Molecule H89 Facilitates Mesenchymal Stem Cell‐derived Extracellular Vesicle Release and Optimizes Therapeutic Efficacy in Liver Regeneration

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT The role of human umbilical cord mesenchymal stem cell‐derived extracellular vesicles (hUCMSC‐EVs) in liver regeneration is promising, yet their clinical translation is hampered by insufficient production. Current strategies targeting their secretion are inefficient and lack a clear mechanistic understanding.
Yu Fu, Yi Ma, Jiajun Zhang, Liwei Liang, Ting Li, Zeyi Guo, Zhongzhe Li, Lei Feng, Yi Wang, Guolin He, Shao Li, Yang Li, Xiaoping Xu, Hui Liao, Yi Gao   +14 more
wiley   +1 more source

Экспрессия кинезинов, вовлеченных в развитие аутофагии у Arabidopsis thaliana, и вклад ацетилирования тубулина во взамодействие белка Atg8 с микротрубочками

Фактори експериментальної еволюції організмів, 2018
Цель. Цель работы заключалась в исследовании взаимосвязи изменений уровней экспрессии генов кинезинов, потенциально вовлеченных в развитие стресс-индуцированной аутофагии у Arabidopsis thaliana с участием микротрубочек, и структурно-биологического ...
V. D. Olenieva, D. I. Lytvyn, A. I. Yemets, Ya. B. Blume   +3 more
doaj   +1 more source

Proteolytic control of mitochondrial protein translocases

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Mitochondria are essential organelles that drive numerous cellular processes, including energy metabolism, ion homeostasis, and programmed cell death. This functional versatility relies on a highly dynamic proteome whose composition is continuously remodeled to meet changing cellular and environmental demands.
Lara Kroczek, Thomas Langer
wiley   +1 more source

Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes

Nature Communications, 2020
The ER is subject to autophagy (ER-phagy) for turnover, with Atg40 acting as a receptor to sequester ER with Atg8 in autophagosomes. Here, the authors show that Atg40 is clustered by interaction with Atg8 to generate local membrane curvature and promote ...
Keisuke Mochida, Akinori Yamasaki, Kazuaki Matoba, Hiromi Kirisako, Nobuo N. Noda, Hitoshi Nakatogawa   +5 more
doaj   +1 more source

Structural and functional insights into TBC1D17 highlight the importance of the previously uncharacterized Rab‐binding domain

Protein Science, Volume 35, Issue 5, May 2026.
Abstract TBC (Tre2/Bub2/Cdc16) domain‐containing proteins constitute the widespread family of GTPase‐activating proteins (GAPs). They interact with the Rab superfamily of small GTPases, stimulate GTP hydrolysis, and regulate vesicle trafficking. TBC1D17, involved in Shiga toxin trafficking, autophagy and glucose metabolism regulation, constitutes an ...
Dominika Nielipińska, Marta Orlikowska, Maciej Nielipiński, Bartosz Sekuła, Katarzyna M. Błażewska, Edyta Gendaszewska‐Darmach, Agnieszka J. Pietrzyk‐Brzezińska   +6 more
wiley   +1 more source

Autophagy-related Atg8 localizes to the apicoplast of the human malaria parasite Plasmodium falciparum.

PLoS ONE, 2012
Autophagy is a membrane-mediated degradation process, which is governed by sequential functions of Atg proteins. Although Atg proteins are highly conserved in eukaryotes, protozoa possess only a partial set of Atg proteins.
Kei Kitamura, Chieko Kishi-Itakura, Takafumi Tsuboi, Shigeharu Sato, Shigeharu Sato, Kiyoshi Kita, Nobuo Ohta, Noboru Mizushima   +7 more
doaj   +1 more source

Advances in Wine Yeast Autolysis: Biochemical and Molecular Mechanisms, and the Release of Organic Compounds in White and Sparkling Wines—An Updated Review

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT Wine yeasts play a central role in alcoholic fermentation and significantly contribute to the sensory attributes of wines through cellular autolysis during lees aging (sur lie), especially in white wines. This process releases organic compounds that alter the wine's chemical and sensory profile.
José Ricardo Machado dos Santos, Aniela Pinto Kempka   +1 more
wiley   +1 more source