Results 51 to 60 of about 11,891 (170)

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

No ATG8s, no problem? How LC3/GABARAP proteins contribute to autophagy [PDF]

Journal of Cell Biology, 2016
The ATG8 family LC3/GABARAP proteins are attached to the membrane of nascent autophagosomes, but their functions during autophagy are unclear. In this issue, Nguyen et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607039) show that LC3/GABARAP proteins are not essential for autophagosome formation but are critical for autophagosome–lysosome ...
openaire   +3 more sources

The Plant ATG8-binding Proteins

Shengwu huaxue yu shengwu wuli jinzhan
ATG8-binding proteins play a key role in autophagy, selective autophagy or non-autophagy process by interacting between ATG8 and the ATG8-interacting motif (AIM) or the ubiquitin-interacting motif (UIM).
ZHANG Feng-Juan, JING Hong-Juan, ZHOU Guang-Zhou, QIN Shuai-Jia, HAN Chu-Yan   +4 more
doaj   +1 more source

FAM134B Restricts African Swine Fever Virus Capsid Assembly via Reticulophagy and Its Antiviral Activity is Antagonized by the Viral Virulence‐Associated Factor pMGF300‐2R

Advanced Science, EarlyView.
ABSTRACT African swine fever (ASF), caused by African swine fever virus (ASFV), is a devastating viral disease in domestic pigs and wild boar. ASFV is a large DNA virus whose capsid assembly takes place within perinuclear viral factories (VFs). Accumulating evidence has demonstrated that reticulophagy confers antiviral activity against multiple RNA ...
Rui Luo, Jing Zhang, Ruojia Huang, Xianfeng Zhang, Lian‐Feng Li, Jing Lan, Zhanhao Lu, Yuan Sun, Tao Wang, Hua‐Ji Qiu   +9 more
wiley   +1 more source

Indirect estimation of the area density of Atg8 on the phagophore [PDF]

Autophagy, 2009
Atg8 is a ubiquitin-like protein that controls the expansion of the phagophore during autophagosome formation. It is recruited to the phagophore during the expansion stage and released upon the completion of the autophagosome. One possible model explaining the function of Atg8 is that it acts as an adaptor of a coat complex.
Zhiping, Xie, Usha, Nair, Jiefei, Geng, Maciej B, Szefler, Edward D, Rothman, Daniel J, Klionsky   +5 more
openaire   +2 more sources

Toward effective Atg8‐based ATTECs: Approaches and perspectives

Journal of Cellular Biochemistry, 2023
AbstractInduction of Atg8‐family protein (LC3/GABARAP proteins in human) interactions with target proteins of interest by proximity‐inducing small molecules offers the possibility for novel targeted protein degradation approaches. However, despite intensive screening campaigns during the last 5 years, no potent ligands for LC3/GABARAPs have been ...
Martin P. Schwalm, Stefan Knapp, Vladimir V. Rogov   +2 more
openaire   +3 more sources

The Xenopus laevis Atg4B Protease: Insights into Substrate Recognition and Application for Tag Removal from Proteins Expressed in Pro- and Eukaryotic Hosts. [PDF]

PLoS ONE, 2015
During autophagy, members of the ubiquitin-like Atg8 protein family get conjugated to phosphatidylethanolamine and act as protein-recruiting scaffolds on the autophagosomal membrane.
Steffen Frey, Dirk Görlich
doaj   +1 more source

The interplay between pathogens and Atg8 family proteins: thousand‐faced interactions

FEBS Open Bio, 2021
Autophagy is an intracellular degradation and recycling process that can also remove pathogenic intracellular bacteria and viruses from within cells (referred to as xenophagy) and activate the adaptive immune responses.
Dávid Tóth, Gábor V. Horváth, Gábor Juhász   +2 more
doaj   +1 more source

Advances in research on autophagy in the maintenance of insect–microbe symbiosis

New Plant Protection, EarlyView.
Autophagy plays a dual regulatory role in insect–microbe symbiotic relationships. Beneficial symbiotic bacteria in insects participate in nutrient exchange via the TOR pathway, whereas pathogenic microbes induce immune defense through the AMPK pathway. Autophagy‐related genes regulate development and pathogen clearance during this process.
Yanbin Wang, Yuqiong Hao, Ke Chen, Hongbin Zhang, Xiansheng Xie, Feirong Ren   +5 more
wiley   +1 more source

Noncanonical ATG8–ABS3 interaction controls senescence in plants [PDF]

Nature Plants, 2019
Protein homeostasis is essential for cellular functions and longevity, and the loss of proteostasis is one of the hallmarks of senescence. Autophagy is an evolutionarily conserved cellular degradation pathway that is critical for the maintenance of proteostasis. Paradoxically, autophagy deficiency leads to accelerated protein loss by unknown mechanisms.
Min Jia, Xiayan Liu, Hui Xue, Yue Wu, Lin Shi, Rui Wang, Yu Chen, Ni Xu, Jun Zhao, Jingxia Shao, Yafei Qi, Lijun An, Jen Sheen, Fei Yu   +13 more
openaire   +2 more sources