Results 51 to 60 of about 429 (86)

Interaction of Potato Autophagy-Related StATG8 Family Proteins with Pathogen Effector and WRKY Transcription Factor in the Nucleus

Microorganisms
Autophagy is an essential eukaryotic catabolic process through which damaged or superfluous cellular components are degraded and recycled via the formation of double-membrane autophagosomes.
Sung Un Huh
doaj   +1 more source

Inferring Gene Regulatory Network Architecture Underlying Complex Traits: An Integrative Analysis of Mutant Lifespan and Gene Expression Profiles Identifies Master Regulators and Key Functional Modules for Yeast Aging

Aging Cell, Volume 25, Issue 5, May 2026.
We developed a LASSO‐based approach to uncover a three‐layered “fan‐in fan‐out” network architecture for complex traits like yeast aging, showing that peripheral genes influence lifespan indirectly through master regulators, which converge on core functional modules (e.g., stress response, autophagy).
Meng Ma, Juan Long, Yuting Chen, Yanqiu Shao, Man Zhu, Jiashun Zheng, Lu Yang, Yin Xiao, Matt Kaeberlein, Brian K. Kennedy, Yi Zheng, Hao Li, Jing Yang   +12 more
wiley   +1 more source

A Decline in Follicle Cell Function Is a Major Driver of Drosophila Ovarian Aging

Aging Cell, Volume 25, Issue 5, May 2026.
Aging drives a progressive accumulation of defects in somatic follicle cells of the Drosophila ovary. These defects are accompanied by reduced tissue and genome integrity, altered transcriptional profiles, and disrupted germ‐soma coordination. Targeted overexpression of Atg8a in a subset of follicle cells mitigates these defects and preserves ...
Emily A. Wolfgram, Todd G. Nystul
wiley   +1 more source

‘Candidatus Liberibacter asiaticus’ Effector SDE4250 Targets Citrus Proteasome Protein RPN10 to Inhibit Salicylic Acid‐Mediated Citrus Immunity

Molecular Plant Pathology, Volume 27, Issue 5, May 2026.
SDE4250 suppressed 26S proteasome activity by targeting CsRPN10 and enhancing its degradation via the proteasome pathway. This impairment of proteasome function subsequently attenuates SA‐mediated defence responses, thereby increasing citrus susceptibility to promote CLas infection.
Yalin Mei, Xinyi Deng, Zaiyu Yang, Qiying Wang, Changyong Zhou, Xuefeng Wang, Yingzhe Yuan, Shimin Fu   +7 more
wiley   +1 more source

Створення потенційних Ilp-маркерів для генів Atg2, Atg7, Atg8 у Hordeum vulgare і H. marinum

Фактори експериментальної еволюції організмів
Мета. Створення потенційних маркерів поліморфізму довжини інтронів для генів ATG2, ATG7 і ATG8. Методи. Методи класичної біоінформатики для пошуку локусів, що кодують білки ATG2, ATG7, ATG8 у геномі Hordeum marinum на основі гомології з генами ...
D. O. Novozhylov, S. O. Hordynskyi, A. M. Rabokon, A. Ye. Demkovych, S. M. Pryvalikhin, R. Y. Blume, А. Yu. Buziashvili, A. I. Yemets, Ya. V. Pirko   +8 more
doaj   +1 more source

ATG8ylation-mediated tonoplast invagination mitigates vacuole damage

Nature Communications
While ATG8ylation, the lipidation of ATG8-family proteins, is canonically linked to double-membrane autophagosome formation, emerging studies demonstrate its non-canonical association with single-membrane organelles.
Xuanang Zheng, Juncai Ma, Jing Li, Siyu Chen, Jun Luo, Jianxiong Wu, Kaiyan Zhang, Changlian Peng, Yonglun Zeng, Faqiang Li, Byung-Ho Kang, Caiji Gao, Jun Zhou   +12 more
doaj   +1 more source

Cloning and Expression Analysis of ATG8 (Autophagy-Related 8) Gene Family in Solanaceae

Plants
The autophagy-related gene family ATG8 (Autophagy-related 8) plays an important role in plant growth, development, and stress response. In this study, 15 ATG8 gene family sequences were amplified from Solanaceae, namely tobacco, tomato, and pepper, using
Yahan Chen, Yunshuang Lu, Shibo Dong, Chengde Yang, Shunyi Yang   +4 more
doaj   +1 more source

A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation

Nature Communications, 2017
Acetylation of Atg3 regulates lipidation of Atg8 and therefore autophagy, but the molecular mechanisms remain unclear. Here, Liet al. semi-synthesize diacetylated Atg3, allowing them to show that acetylated Atg3 enhances Atg8 lipidation by promoting ...
Yi-Tong Li, Cong Yi, Chen-Chen Chen, Huan Lan, Man Pan, Shao-Jin Zhang, Yi-Chao Huang, Chao-Jian Guan, Yi-Ming Li, Li Yu, Lei Liu   +10 more
doaj   +1 more source

Genotype-Specific Activation of Autophagy during Heat Wave in Wheat

Cells
Recycling of unnecessary or dysfunctional cellular structures through autophagy plays a critical role in cellular homeostasis and environmental resilience.
Kathleen Hickey, Yunus Şahin, Glenn Turner, Taras Nazarov, Vadim Jitkov, Mike Pumphrey, Andrei Smertenko   +6 more
doaj   +1 more source

Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation

Nature Communications, 2017
The protease Atg4 mediates Atg8 lipidation, required for autophagosome biogenesis, but also triggers Atg8 release from the membranes, however is unclear how these steps are coordinated.
Jana Sánchez-Wandelmer, Franziska Kriegenburg, Sabrina Rohringer, Martina Schuschnig, Rubén Gómez-Sánchez, Bettina Zens, Susana Abreu, Ralph Hardenberg, David Hollenstein, Jieqiong Gao, Christian Ungermann, Sascha Martens, Claudine Kraft, Fulvio Reggiori   +13 more
doaj   +1 more source