Results 61 to 70 of about 429 (86)

Pbs2 regulates late‐stage macroautophagy in Saccharomyces cerevisiae

open access: yesAnimal Models and Experimental Medicine
Autophagy is crucial for maintaining cellular homeostasis and is linked to various diseases. In Saccharomyces cerevisiae, the Polymyxin B Sensitivity 2 (Pbs2) protein is a member of the mitogen‐activated protein kinase (MAPK) family and plays a role in ...
Jianing Song   +8 more
doaj   +1 more source

The Role of ATG8 in Promoting Lipid Accumulation in the Oleaginous Fungus Mucor circinelloides During Nitrogen Limitation

open access: yesJournal of Fungi
Autophagy is a central cellular process that recycles intracellular components and supplies precursors for biosynthesis. As a key regulator of autophagosome formation, autophagy-related protein 8 (ATG8) plays an essential role in macromolecular ...
Hequn Li   +5 more
doaj   +1 more source

ATG8 delipidation is not universally critical for autophagy in plants

open access: yesNature Communications
Intracellular recycling via autophagy is governed by post-translational modifications of the autophagy-related (ATG) proteins. One notable example is ATG4-dependent delipidation of ATG8, a process that plays critical but distinct roles in autophagosome ...
Yong Zou   +13 more
doaj   +1 more source

Two distinct regulatory pathways govern Cct2-Atg8 binding in the process of solid aggrephagy

open access: yesEMBO Reports
CCT2 serves as an aggrephagy receptor that plays a crucial role in the clearance of solid aggregates, yet the underlying molecular mechanisms by which CCT2 regulates solid aggrephagy are not fully understood.
Yuting Chen   +17 more
doaj   +1 more source

HLS1 interacts with ATG8 to negatively regulate the ABS3-mediated plant senescence pathway

open access: yesCell Reports
Summary: In Arabidopsis, late endosome-localized ABNORMAL SHOOT 3 (ABS3) promotes senescence through a direct interaction with AUTOPHAGY8 (ATG8). However, the molecular mechanisms underlying the regulation of the ABS3-mediated senescence pathway are not ...
Pei Lei   +9 more
doaj   +1 more source

Transcription Factor Deformed Wings Is an Atg8a-Interacting Protein That Regulates Autophagy

open access: yesCells
LC3 (microtubule-associated protein 1 light chain 3, called Atg8 in yeast and Drosophila) is one of the most well-studied autophagy-related proteins. LC3 controls the selectivity of autophagic degradation by interacting with LIR (LC3-interacting region ...
Marta Kołodziej   +3 more
doaj   +1 more source

Discovery of Evolutionary Loss of the Ubiquitin-like Autophagy-Related ATG12 System in a Lineage of Apicomplexa

open access: yesCells
The autophagy-related ubiquitin-like conjugation systems, the ATG8 and ATG12 systems, are universally conserved in eukaryotes. However, the covalent bond in the ATG12 system has recently been shown to be evolutionarily lost in Apicomplexa.
Xiaoxia X. Lin   +8 more
doaj   +1 more source

Characterization of ATG8-family protein phosphorylation by Phos-tag gel for autophagy study

open access: yesSTAR Protocols
Summary: Autophagy supports cell survival under different stress conditions, where ATG8-family proteins are required for autophagosome biogenesis/maturation and selective autophagy.
Gayoung Seo, Wenqi Wang
doaj   +1 more source
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Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine

Molecular Cell, 2021
Alf Hakon Lystad   +2 more
exaly  

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