Role of Atg8 in the regulation of vacuolar membrane invagination
Scientific Reports, 2019 Cellular heat stress can cause damage, and significant changes, to a variety of cellular structures. When exposed to chronically high temperatures, yeast cells invaginate vacuolar membranes.
Ayane Ishii +7 more
doaj +1 more source
Structure and Dynamics in the ATG8 Family From Experimental to Computational Techniques
Frontiers in Cell and Developmental Biology, 2020 Autophagy is a conserved and essential intracellular mechanism for the removal of damaged components. Since autophagy deregulation is linked to different kinds of pathologies, it is fundamental to gain knowledge on the fine molecular and structural ...
Valentina Sora +6 more
doaj +1 more source
The autophagic degradation of cytosolic pools of peroxisomal proteins by a new selective pathway. [PDF]
, 2019 Damaged or redundant peroxisomes and their luminal cargoes are removed by pexophagy, a selective autophagy pathway. In yeasts, pexophagy depends mostly on the pexophagy receptors, such as Atg30 for Pichia pastoris and Atg36 for Saccharomyces cerevisiae ...
Farré, Jean-Claude +8 more
core +2 more sources
Real-Time Monitoring of ATG8 Lipidation in vitro Using Fluorescence Spectroscopy
Bio-ProtocolAutophagy is an essential catabolic pathway used to sequester and engulf cytosolic substrates via a unique double-membrane structure, called an autophagosome.
Wenxin Zhang +2 more
doaj +1 more source
Beyond Atg8 binding: The role of AIM/LIR motifs in autophagy [PDF]
Autophagy, 2017 Selective macroautophagy/autophagy mediates the selective delivery of cytoplasmic cargo material via autophagosomes into the lytic compartment for degradation. This selectivity is mediated by cargo receptor molecules that link the cargo to the phagophore (the precursor of the autophagosome) membrane via their simultaneous interaction with the cargo and
Dorotea Fracchiolla +2 more
openaire +3 more sources
The DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer. [PDF]
, 2015 While carcinoma of the prostate is the second most common cause of cancer death in the US, current methods and markers used to predict prostate cancer (PCa) outcome are inadequate.
Benner, Christopher +2 more
core +2 more sources
Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine [PDF]
Molecular Cell, 2020 AbstractAutophagy is a fundamental catabolic process essential for development, homeostasis and proper immune function1. During autophagy, a cascade of ATG proteins target intracellular cargoes for lysosomal degradation and recycling2.
Joanne Durgan +13 more
openaire +6 more sources
Journal of FungiAutophagy, a conserved cellular recycling process, plays a crucial role in maintaining homeostasis under stress conditions. It also regulates the development and virulence of numerous filamentous fungi.
Qingru Geng +12 more
doaj +1 more source
The Xenopus laevis Atg4B Protease: Insights into Substrate Recognition and Application for Tag Removal from Proteins Expressed in Pro- and Eukaryotic Hosts. [PDF]
PLoS ONE, 2015 During autophagy, members of the ubiquitin-like Atg8 protein family get conjugated to phosphatidylethanolamine and act as protein-recruiting scaffolds on the autophagosomal membrane.
Steffen Frey, Dirk Görlich
doaj +1 more source
Unfolding Plant Defence: Endoplasmic Reticulum Stress Signalling at the Plant‐Pathogen Interface
Plant Biotechnology Journal, EarlyView.ABSTRACT The endoplasmic reticulum (ER) stress response, a conserved proteostasis network, has emerged as a central hub that reprograms plant immunity during pathogen attack. This review synthesises how plants harness ER‐stress signalling to mount multilayered defences and how pathogens have evolved counterstrategies to subvert these pathways.
Zhe Meng +8 more
wiley +1 more source