Results 61 to 70 of about 11,891 (170)

Conjugation of ATG8s to single membranes at a glance

Journal of Cell Science
ABSTRACT Autophagy refers to a set of degradative mechanisms whereby cytoplasmic contents are targeted to the lysosome. This is best described for macroautophagy, where a double-membrane compartment (autophagosome) is generated to engulf cytoplasmic contents.
Carmen Figueras-Novoa, Lewis Timimi, Elena Marcassa, Rachel Ulferts, Rupert Beale   +4 more
openaire   +2 more sources

Proximity-dependent biotinylation screening identifies NbHYPK as a novel interacting partner of ATG8 in plants

BMC Plant Biology, 2019
Background Autophagy is a conserved, highly-regulated catabolic process that plays important roles in growth, development and innate immunity in plants.
Mercy W. Macharia, Wilfred Y. Z. Tan, Prem P. Das, Naweed I. Naqvi, Sek-Man Wong   +4 more
doaj   +1 more source

Aspartic Protease Inhibition Induces Proteomic Remodeling in Paracoccidioides brasiliensis

PROTEOMICS, EarlyView.
ABSTRACT Paracoccidioidomycosis (PCM) is a major systemic mycosis in Latin America caused by Paracoccidioides brasiliensis, yet the contribution of aspartic proteases to fungal physiology and pathogenicity remains poorly understood. Here, we employed data‐independent acquisition (DIA)‐based quantitative proteomics to investigate the impact of pepstatin
Sarah Fernandes Lima, Wilson Dias Segura, Leonardo Brogliato de Moraes, Reinaldo Souza Oliveira, Pedro Henrique Corteletti Manfio, Alison Felipe Alencar Chaves, Wagner Luiz Batista   +6 more
wiley   +1 more source

Atg8‐family interacting motif crucial for selective autophagy [PDF]

FEBS Letters, 2010
Autophagy is a bulk degradation system conserved among most eukaryotes. Recently, autophagy has been shown to mediate selective degradation of various targets such as aggregated proteins and damaged or superfluous organelles. Structural studies have uncovered the conserved specific interactions between autophagic receptors and Atg8‐family proteins ...
Nobuo N. Noda, Yoshinori Ohsumi, Fuyuhiko Inagaki   +2 more
openaire   +2 more sources

Colocalization Assay with Fluorescent-tagged ATG8 Using a Nicotiana benthamiana-based Transient System

Bio-Protocol, 2022
Autophagy is an evolutionarily conserved intracellular degradation process. During autophagy, a set of autophagy-related (ATG) proteins orchestrate the formation of double-bound membrane vesicles called autophagosomes to engulf cytoplasmic material and ...
Jinyan Mai, Dandan Shang, Faqiang Li, Na Luo   +3 more
doaj   +1 more source

A horizontally acquired pantothenate gene drives vitellogenin's benefit to whitefly symbiosis persistence

Insect Science, EarlyView.
This diagram illustrates that the horizontally transferred panBC influences the level and localization of vitellogenin (Vg) by facilitating pantothenate production and juvenile hormone (JH) biosynthesis. In turn, Vg shields symbionts by suppressing autophagic degradation in bacteriocytes.
Xiang Sun, Bing‐Qi Liu, Zhan‐Bo Chen, Chu‐Qiao Li, Xing‐Ye Li, Jun‐Bo Luan   +5 more
wiley   +1 more source

In silico modeling of the Moniliophthora perniciosa Atg8 protein

Genetics and Molecular Research, 2013
Autophagy is defined as an intracellular system of lysosomal degradation in eukaryotic cells, and the genes involved in this process are conserved from yeast to humans. Among these genes, ATG8 encodes a ubiquitin-like protein that is conjugated to a phosphatidylethanolamine (PE) membrane by the ubiquitination system.
A C F, Pereira, T H S, Cardoso, M, Brendel, C, Pungartnik   +3 more
openaire   +2 more sources

A live‐cell autophagy reporter reveals reversible vacuolation in naked mole‐rat skin fibroblasts under lysosomal stress

The FEBS Journal, EarlyView.
A tandem fluorescent mCherry–EGFP–LC3 reporter enables live‐cell visualisation of autophagy–lysosome dynamics in naked mole‐rat skin fibroblasts. Chloroquine‐induced lysosomal stress promotes accumulation of neutral LC3‐positive compartments and triggers pronounced LC3‐associated vacuolation.
Fangze Tong, Mateo P. Hoare, Laura J. Grundy, Filomena Gallo, Karin H. Müller, Ewan St. John Smith, Janet R. Kumita   +6 more
wiley   +1 more source

Canonical and non-canonical roles for ATG8 proteins in autophagy and beyond

Frontiers in Molecular Biosciences, 2022
During autophagy, the ATG8 family proteins have several well-characterized roles in facilitating early, mid, and late steps of autophagy, including autophagosome expansion, cargo recruitment and autophagosome-lysosome fusion.
Steven Edward Reid, Srinivasa Prasad Kolapalli, Thorbjørn M. Nielsen, Lisa B. Frankel, Lisa B. Frankel   +4 more
doaj   +1 more source

High‐variance phenome database reveals important roles of WD40 proteins in the plant pathogenic fungus Fusarium graminearum

New Phytologist, EarlyView.
Functional analysis of predicted interaction‐associated WD40 blades in Fgwd101 and Fgwd048 of Fusarium graminearum. Summary WD40 is a highly conserved protein domain in eukaryotes that functions as a versatile platform for protein–protein interactions and participates in diverse biological processes.
Soyoung Choi, Nahyun Lee, Jiyeun Park, Hosung Jeon, Sieun Kim, Jung‐Eun Kim, Jiyoung Shin, Heeji Moon, Kyunghun Min, Yejin Choi, Aram Hwangbo, Hun Kim, Gyung Ja Choi, Yin‐Won Lee, Dae‐Geun Song, Hokyoung Son   +15 more
wiley   +1 more source