A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins [PDF]
Cells, 2020 Gap junctions (GJ) are specialized cell-cell contacts formed by connexins (Cxs), which provide direct communication between adjacent cells. Cx43 ubiquitination has been suggested to induce the internalization of GJs, as well as the recruitment of the ...
S Catarino +2 more
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LIR Motif-Containing Hyperdisulfide β-Ginkgotide is Cytoprotective, Adaptogenic, and Scaffold-Ready [PDF]
Molecules, 2019 Grafting a bioactive peptide onto a disulfide-rich scaffold is a promising approach to improve its structure and metabolic stability. The ginkgo plant-derived β-ginkgotide β-gB1 is a highly unusual molecule: Small, hyperdisulfide, and found ...
Janet To +2 more
exaly +4 more sources
An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy [PDF]
PLoS PathogensRift Valley fever virus (RVFV) is a viral zoonosis that causes severe disease in ruminants and humans. The nonstructural small (NSs) protein is the primary virulence factor of RVFV that suppresses the host's antiviral innate immune response ...
Kylene Kehn-Hall, Maryna Akhrymuk
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Discovering host-viral protein interactions in autophagy: A LIR discovery pipeline for identifying LC3-interacting region motifs in highly virulent viruses. [PDF]
PLoS PathogensHemorrhagic fever virus (HFV) infections are highly fatal, posing a significant global pandemic threat as they continue to emerge in new locations. HFVs and other highly virulent viruses (HVVs), such as Nipah virus, exploit host cell pathways, including ...
Kaylee D Petraccione +10 more
doaj +2 more sources
FAM134B Restricts African Swine Fever Virus Capsid Assembly via Reticulophagy and Its Antiviral Activity is Antagonized by the Viral Virulence-Associated Factor pMGF300-2R. [PDF]
Adv Sci (Weinh)ABSTRACT African swine fever (ASF), caused by African swine fever virus (ASFV), is a devastating viral disease in domestic pigs and wild boar. ASFV is a large DNA virus whose capsid assembly takes place within perinuclear viral factories (VFs). Accumulating evidence has demonstrated that reticulophagy confers antiviral activity against multiple RNA ...
Luo R +9 more
europepmc +2 more sources
Atg8 family proteins, LIR/AIM motifs and other interaction modes
Autophagy Reports, 2023 The Atg8 family of ubiquitin-like proteins play pivotal roles in autophagy and other processes involving vesicle fusion and transport where the lysosome/vacuole is the end station. Nuclear roles of Atg8 proteins are also emerging.
Terje Johansen
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Two specific interactions of GATE16 with TRPML3 and RAB33B regulate autophagy [PDF]
Scientific ReportsATG8s are essential for autophagy as they recruit various machinery to autophagic structures. We previously reported that the intracellular Ca2+ channel TRPML3 specifically interacts with the mammalian ATG8 homolog GATE16, but not LC3B to increase ...
Jiwoo Park +5 more
doaj +2 more sources
Conserved LIR-specific interaction of Sigma-1 receptor and GABARAP [PDF]
iScienceSummary: Among its various functions, the sigma-1 receptor (σ1R) has been reported to modulate macroautophagy. It is currently unknown how this activity is mediated. We phylogenetically, structurally, and biochemically analyzed σ1R regarding its function
Marius Wilhelm Baeken +7 more
doaj +2 more sources
An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5 [PDF]
Autophagy, 2020 Volker Dotsch +2 more
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iLIR@viral: A web resource for LIR motif-containing proteins in viruses [PDF]
Autophagy, 2017 Anne-Claire Jacomin, Ioannis Nezis
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