LIR Motif-Containing Hyperdisulfide β-Ginkgotide is Cytoprotective, Adaptogenic, and Scaffold-Ready [PDF]
Molecules, 2019 Grafting a bioactive peptide onto a disulfide-rich scaffold is a promising approach to improve its structure and metabolic stability. The ginkgo plant-derived β-ginkgotide β-gB1 is a highly unusual molecule: Small, hyperdisulfide, and found ...
Bamaprasad Dutta +3 more
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A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins [PDF]
Cells, 2020 Gap junctions (GJ) are specialized cell-cell contacts formed by connexins (Cxs), which provide direct communication between adjacent cells. Cx43 ubiquitination has been suggested to induce the internalization of GJs, as well as the recruitment of the ...
Steve Catarino +6 more
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An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy. [PDF]
PLoS PathogensRift Valley fever virus (RVFV) is a viral zoonosis that causes severe disease in ruminants and humans. The nonstructural small (NSs) protein is the primary virulence factor of RVFV that suppresses the host's antiviral innate immune response ...
Kaylee Petraccione +14 more
doaj +4 more sources
Two specific interactions of GATE16 with TRPML3 and RAB33B regulate autophagy [PDF]
Scientific ReportsATG8s are essential for autophagy as they recruit various machinery to autophagic structures. We previously reported that the intracellular Ca2+ channel TRPML3 specifically interacts with the mammalian ATG8 homolog GATE16, but not LC3B to increase ...
Jiwoo Park +5 more
doaj +2 more sources
Conserved LIR-specific interaction of Sigma-1 receptor and GABARAP [PDF]
iScienceSummary: Among its various functions, the sigma-1 receptor (σ1R) has been reported to modulate macroautophagy. It is currently unknown how this activity is mediated. We phylogenetically, structurally, and biochemically analyzed σ1R regarding its function
Marius Wilhelm Baeken +7 more
doaj +2 more sources
Extracellular vesicle-based targeted protein degradation platform for multiple extracellular proteins [PDF]
EMBO Molecular MedicineTargeted protein degradation (TPD) is an emerging therapeutic approach that enables the degradation of undruggable targets via intracellular degradation systems.
Bide Tong +17 more
doaj +2 more sources
Caspase cleavage of influenza A virus M2 disrupts M2-LC3 interaction and regulates virion production [PDF]
EMBO ReportsInfluenza A virus (IAV) Matrix 2 protein (M2) is an ion channel, required for efficient viral entry and egress. M2 interacts with the small ubiquitin-like LC3 protein through a cytoplasmic C-terminal LC3-interacting region (LIR).
Carmen Figueras-Novoa +8 more
doaj +2 more sources
TMEM259/MEMBRALIN is a non-canonical ER-phagy receptor that associates with MAN1B1 and VCP to eliminate viral glycoproteins [PDF]
Autophagy ReportsSelective autophagy of the endoplasmic reticulum (ER-phagy/reticulophagy) is essential for organelle homeostasis and host defense, yet how ER quality control (ERQC) pathways distinguish viral glycoproteins from misfolded host proteins remains poorly ...
Jim Maurice Camilleri +5 more
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Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor [PDF]
Nature CommunicationsWnt signal transduction relies on the direct inhibition of GSK3 by phosphorylated PPPSPxS motifs within the cytoplasmic tail of the LRP6 co-receptor. How GSK3 is recruited to LRP6 remains unclear.
Melissa V. Gammons +6 more
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BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM [PDF]
The EMBO JournalRecent studies have identified a family of rod-shaped proteins thought to mediate lipid transfer at intracellular membrane contacts by a bridge-like mechanism.
Michael G Hanna +8 more
doaj +2 more sources