Results 11 to 20 of about 240,005 (160)

The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif [PDF]

Acta Crystallographica Section F, Structural Biology Communications, 2017
FYVE and coiled-coil domain-containing protein 1 (FYCO1), a multidomain autophagy adaptor protein, mediates microtubule plus-end-directed autophagosome transport by interacting with kinesin motor proteins and with the autophagosomal membrane components ...
Taisuke Tomita, Shimizu Toshiyuki
exaly   +6 more sources

iLIR database: A web resource for LIR motif-containing proteins in eukaryotes [PDF]

Autophagy, 2016
Atg8-family proteins are the best-studied proteins of the core autophagic machinery. They are essential for the elongation and closure of the phagophore into a proper autophagosome.
Anne-Claire Jacomin, Ioannis Nezis, Vasilis Promponas   +2 more
exaly   +8 more sources

ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8 [PDF]

Autophagy, 2017
The cysteine protease ATG4B cleaves off one or more C-terminal residues of the inactive proform of proteins of the ortholog and paralog LC3 and GABARAP subfamilies of yeast Atg8 to expose a C-terminal glycine that is conjugated to ...
Kenneth Bowitz Larsen, Nirmal Vadgama, Trond Lamark   +2 more
exaly   +6 more sources

FYCO1 Contains a C-terminally Extended, LC3A/B-preferring LC3-interacting Region (LIR) Motif Required for Efficient Maturation of Autophagosomes during Basal Autophagy [PDF]

Journal of Biological Chemistry, 2015
FYCO1 (FYVE and coiled-coil protein 1) is a transport adaptor that binds to phosphatidylinositol 3-phosphate, to Rab7, and to LC3 (microtubule-associated protein 1 light chain 3) to mediate transport of late endosomes and autophagosomes along ...
Kenneth Bowitz Larsen, Trond Lamark, Terje Johansen   +2 more
exaly   +8 more sources

Human ATG3 contains a non-canonical LIR motif crucial for its enzymatic activity in autophagy

, 2022
Macroautophagy is one of two major degradation systems in eukaryotic cells. Regulation and control of autophagy is often achieved through the presence of short peptide sequences called LC3 interacting regions (LIR) in autophagy-involved proteins. Using a
Farnung J, Muhar M, Liang JR, Tolmachova KA, Benoit RM, Corn JE, Bode JW.   +6 more
europepmc   +3 more sources

LIRcentral: a manually curated online database of experimentally validated functional LIR motifs

Autophagy, 2023
Several selective macroautophagy receptor and adaptor proteins bind members of the Atg8 (autophagy related 8) family using short linear motifs (SLiMs), most often referred to as Atg8-family interacting motifs (AIMs) or LC3-interacting regions (LIRs). AIM/
Vasileios Sagris (16732362), Nicholas Price (16295150), Ioannis Iliopoulos (1338), Marios Eftychiou (16732368), Ioanna Kalvari (16732371), Agathangelos Chatzichristofi (16732359), Ioannis P. Nezis (8199771), Vasilis J Promponas (16732377), Aristos Pallaris (16732365), Theodosios Theodosiou (16732374)   +9 more
core   +5 more sources

LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy [PDF]

Molecular Cell, 2012
Autophagy protects cellular homeostasis by capturing cytosolic components and invading pathogens for lysosomal degradation. Autophagy receptors target cargo to autophagy by binding ATG8 on autophagosomal membranes. The expansion of the ATG8 family in higher eukaryotes suggests that specific interactions with autophagy receptors facilitate differential ...
Trevor Rutherford, Stefan Mv Freund, David Komander   +2 more
exaly   +4 more sources

Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs [PDF]

Autophagy, 2019
Autophagosome formation depends on a carefully orchestrated interplay between membrane-associated protein complexes. Initiation of macroautophagy/autophagy is mediated by the ULK1 (unc-51 like autophagy activating kinase 1) protein kinase complex and the
Sharon A. Tooze (391543), Eva Sjøttem (8255), Martina Wirth (3832903), Åsa Birna Birgisdottir (6368132), Evjen, G, Bhujabal, Zambarlal, Nicola O’Reilly (2218060), Lee, Rebecca, O'Reilly, Nicola, Wenxin Zhang (112161), Lamark, T, O'Reilly, N, Stephane Mouilleron (5166308), Lee, R, Tooze, SA, Johansen, Terje, Trond Lamark (175604), Sjottem, E, Sjøttem, Eva, Evjen, Gry, Birgisdottir, AB, Mouilleron, S, Zhang, W, Wirth, Martina, Mouilleron, Stephane, Wirth, M, Johansen, T, Gry Evjen (6368138), Rebecca Lee (624698), Tooze, Sharon A, Bhujabal, Z, Zambarlal Bhujabal (6368135), Lamark, Trond, Zhang, Wenxin, Birgisdottir, Åsa Birna, Terje Johansen (25018)   +35 more
core   +7 more sources

ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex SEQUENCE REQUIREMENTS FOR LC3-INTERACTING REGION (LIR) MOTIFS [PDF]

The Journal of biological chemistry, 2012
Autophagy is a lysosome-dependent degradation system conserved among eukaryotes. The mammalian Atg1 homologues, Unc-51 like kinase (ULK) 1 and 2, are multifunctional proteins with roles in autophagy, neurite outgrowth, and vesicle transport.
Birgisdottir, Åsa birna, Olsvik, Hallvard Lauritz, Lamark, Trond, Øvervatn, Aud Karin, Alemu, Endalkachew Ashenafi, Kirkin, Vladimir, Torgersen, Knut Martin, Larsen, Kenneth Bowitz, Jain, Ashish, Johansen, Terje   +9 more
core   +5 more sources

Extracellular vesicle-based targeted protein degradation platform for multiple extracellular proteins [PDF]

EMBO Molecular Medicine
Targeted protein degradation (TPD) is an emerging therapeutic approach that enables the degradation of undruggable targets via intracellular degradation systems.
Bide Tong, Xiaoguang Zhang, Dingchao Zhu, Yulei Wang, Junyu Wei, Zixuan Ou, Huaizhen Liang, Hanpeng Xu, Zhengdong Zhang, Jie Lei, Xingyu Zhou, Di Wu, Yu Song, Kun Wang, Xiaobo Feng, Lei Tan, Zhiwei Liao, Cao Yang   +17 more
doaj   +2 more sources