Results 11 to 20 of about 3,587 (132)

FYCO1 Contains a C-terminally Extended, LC3A/B-preferring LC3-interacting Region (LIR) Motif Required for Efficient Maturation of Autophagosomes during Basal Autophagy [PDF]

Journal of Biological Chemistry, 2015
FYCO1 (FYVE and coiled-coil protein 1) is a transport adaptor that binds to phosphatidylinositol 3-phosphate, to Rab7, and to LC3 (microtubule-associated protein 1 light chain 3) to mediate transport of late endosomes and autophagosomes along microtubules in the plus end direction.
Hallvard Olsvik, Trond Lamark, Kenneth Bowitz Larsen   +2 more
exaly   +8 more sources

Human ATG3 contains a non-canonical LIR motif crucial for its enzymatic activity in autophagy

, 2022
Abstract Macroautophagy is one of two major degradation systems in eukaryotic cells. Regulation and control of autophagy is often achieved through the presence of short peptide sequences called LC3 interacting regions (LIR) in autophagy-involved proteins.
Farnung J, Muhar M, Liang JR, Tolmachova KA, Benoit RM, Corn JE, Bode JW.   +6 more
europepmc   +3 more sources

Conserved LIR-specific interaction of Sigma-1 receptor and GABARAP [PDF]

iScience
Summary: Among its various functions, the sigma-1 receptor (σ1R) has been reported to modulate macroautophagy. It is currently unknown how this activity is mediated. We phylogenetically, structurally, and biochemically analyzed σ1R regarding its function
Marius Wilhelm Baeken, Maximilian Christ, Daniel Schmitt, Wencke Trein, Heike Nagel, Albrecht Martin Clement, Hagen Körschgen, Christian Behl   +7 more
doaj   +4 more sources

LIRcentral: a manually curated online database of experimentally validated functional LIR-motifs

Autophagy, 2022
Abstract Several selective macroautophagy receptor and adaptor proteins bind members of the Autophagy-related protein 8 (Atg8) family using short linear motifs (SLiMs), most often referred to as Atg8-interacting motifs (AIM) or LC3-interacting motifs (LIR).
Agathangelos Chatzichristofi, Vasileios Sagris, Aristos Pallaris, Marios Eftychiou, Ioanna Kalvari, Nicholas Price, Theodosios Theodosiou, Ioannis Iliopoulos, Ioannis P. Nezis, Vasilis J Promponas   +9 more
core   +5 more sources

Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs [PDF]

Autophagy, 2019
Autophagosome formation depends on a carefully orchestrated interplay between membrane-associated protein complexes. Initiation of macroautophagy/autophagy is mediated by the ULK1 (unc-51 like autophagy activating kinase 1) protein kinase complex and the autophagy-specific class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1).
Åsa Birna Birgisdottir, Stephane Mouilleron, Zambarlal Bhujabal, Martina Wirth, Eva Sjøttem, Gry Evjen, Wenxin Zhang, Rebecca Lee, Nicola O’Reilly, Sharon A. Tooze, Trond Lamark, Terje Johansen   +11 more
core   +7 more sources

Two specific interactions of GATE16 with TRPML3 and RAB33B regulate autophagy [PDF]

Scientific Reports
ATG8s are essential for autophagy as they recruit various machinery to autophagic structures. We previously reported that the intracellular Ca2+ channel TRPML3 specifically interacts with the mammalian ATG8 homolog GATE16, but not LC3B to increase ...
Jiwoo Park, Areum Choi, Jin Kwon, Suzi Choi, Yun Min Park, Hyun Jin Kim   +5 more
doaj   +2 more sources

Analysis of the native conformation of the LIR/AIM motif in the Atg8/LC3/GABARAP-binding proteins [PDF]

Autophagy, 2015
The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy). This interaction occurs primarily via a conserved motif termed the LC3-interacting region (LIR), or the Atg8-interacting motif (AIM).
Hana Popelka, Daniel J Klionsky
exaly   +3 more sources

Beyond Atg8 binding: The role of AIM/LIR motifs in autophagy [PDF]

Autophagy, 2017
Selective macroautophagy/autophagy mediates the selective delivery of cytoplasmic cargo material via autophagosomes into the lytic compartment for degradation. This selectivity is mediated by cargo receptor molecules that link the cargo to the phagophore (the precursor of the autophagosome) membrane via their simultaneous interaction with the cargo and
Dorotea Fracchiolla, Justyna Sawa-Makarska, Sascha Martens   +2 more
exaly   +4 more sources

Insights into links between autophagy and the ubiquitin system from the structure of LC3B bound to the LIR motif from the E3 ligase NEDD4. [PDF]

Protein Sci, 2017
AbstractMembers of the LC3/GABARAP family of ubiquitin‐like proteins function during autophagy by serving as membrane linked protein‐binding platforms. Their C‐termini are physically attached to membranes through covalent linkage to primary amines on lipids such as phosphatidylethanolamine, while their ubiquitin‐like fold domains bind “LIR” (LC3 ...
Qiu Y, Zheng Y, Wu KP, Schulman BA.
europepmc   +4 more sources

Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors

Journal of Molecular Biology, 2020
Selective autophagy relies on soluble or membrane-bound cargo receptors that recognize cargo and bring about autophagosome formation at the cargo. The cargo-bound receptors interact with lipidated ATG8 family proteins anchored in the membrane at the concave side of the forming autophagosome.
Terje Johansen, Trond Lamark
exaly   +4 more sources